SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fb0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 2fb0 CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A  38
GLU A  54
HIS A  65
MET A  84
 ACT  A 901 (-4.7A)
ACT  A 901 (-2.9A)
ACT  A 901 (-3.9A)
None
 0.62A 1tuvA-2fb0A:
13.2		 1tuvA-2fb0A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_A_COCA401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2fb0 CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 TYR A  38
TYR A  74
GLN A  79
MET A  84
ILE A  78
 ACT  A 901 (-4.7A)
None
None
None
None
 1.39A 2pgzA-2fb0A:
0.0
2pgzB-2fb0A:
0.0		 2pgzA-2fb0A:
18.48
2pgzB-2fb0A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 2fb0 CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A  71
GLU A  66
TYR A  38
LEU A  86
 ACT  A 901 (-4.7A)
None
ACT  A 901 (-4.7A)
None
 0.86A 3i45A-2fb0A:
undetectable		 3i45A-2fb0A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 2fb0 CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A  76
ILE A  77
VAL A  10
VAL A   8
 None
 0.79A 3ufnB-2fb0A:
undetectable		 3ufnB-2fb0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 2fb0 CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A  87
LYS A  85
ASN A   5
 GOL  A 804 (-4.6A)
None
None
 1.09A 4y1dA-2fb0A:
undetectable
4y1dD-2fb0A:
undetectable		 4y1dA-2fb0A:
19.88
4y1dD-2fb0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2fb0 CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A  52
ALA A  27
THR A  26
TYR A  38
 None
None
None
ACT  A 901 (-4.7A)
 0.83A 5ecnD-2fb0A:
undetectable		 5ecnD-2fb0A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2fb0 CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ASN A  11
THR A  13
ASN A  14
GLU A  83
 None
 1.22A 5uigA-2fb0A:
2.1		 5uigA-2fb0A:
12.62