SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fbe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 2fbe PREDICTED: SIMILAR
TO RET FINGER
PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 7 ALA A 113
LEU A 101
SER A  96
THR A 115
 None
 1.01A 1dvxA-2fbeA:
undetectable		 1dvxA-2fbeA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 2fbe PREDICTED: SIMILAR
TO RET FINGER
PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 7 ALA A 113
LEU A 101
SER A  96
THR A 115
 None
 1.02A 1dvxB-2fbeA:
undetectable		 1dvxB-2fbeA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2fbe PREDICTED: SIMILAR
TO RET FINGER
PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 5 GLY A  99
SER A 114
THR A 102
PHE A 100
 None
 1.36A 1icvA-2fbeA:
undetectable
1icvB-2fbeA:
undetectable		 1icvA-2fbeA:
23.11
1icvB-2fbeA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2fbe PREDICTED: SIMILAR
TO RET FINGER
PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 5 GLY A  99
SER A 114
THR A 102
PHE A 100
 None
 1.29A 1kqbA-2fbeA:
undetectable
1kqbB-2fbeA:
undetectable		 1kqbA-2fbeA:
21.70
1kqbB-2fbeA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2fbe PREDICTED: SIMILAR
TO RET FINGER
PROTEIN-LIKE 1
(Homo
sapiens) 		3 / 3 ARG A 165
GLU A  46
THR A  18
 None
 0.72A 3v4tA-2fbeA:
undetectable		 3v4tA-2fbeA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2fbe PREDICTED: SIMILAR
TO RET FINGER
PROTEIN-LIKE 1
(Homo
sapiens) 		3 / 3 ARG A  59
ARG A  88
ASP A  17
 None
 0.71A 3wipG-2fbeA:
undetectable
3wipH-2fbeA:
undetectable		 3wipG-2fbeA:
23.81
3wipH-2fbeA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 2fbe PREDICTED: SIMILAR
TO RET FINGER
PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 6 LEU A  55
THR A  18
ARG A  88
ARG A  59
 None
 1.21A 6gtqB-2fbeA:
undetectable
6gtqD-2fbeA:
undetectable		 6gtqB-2fbeA:
22.60
6gtqD-2fbeA:
12.63