SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fbm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 11 ILE A 286
ALA A 336
ILE A 383
LEU A 321
ILE A 297
 None
 1.04A 1dhiB-2fbmA:
undetectable		 1dhiB-2fbmA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 12 ILE A 286
ALA A 336
ILE A 383
LEU A 321
ILE A 297
 None
 1.03A 1dhjB-2fbmA:
undetectable		 1dhjB-2fbmA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 12 ILE A 286
ALA A 336
ILE A 383
LEU A 321
ILE A 297
 None
 1.03A 1draB-2fbmA:
undetectable		 1draB-2fbmA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 12 ILE A 286
ALA A 336
ILE A 383
LEU A 321
ILE A 297
 None
 1.01A 1drbB-2fbmA:
undetectable		 1drbB-2fbmA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		3 / 3 ILE A 286
ILE A 297
THR A 301
 None
 0.59A 1rg7A-2fbmA:
undetectable		 1rg7A-2fbmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 12 ILE A 286
ILE A 383
LEU A 321
ILE A 297
THR A 301
 None
 1.03A 1rx2A-2fbmA:
undetectable		 1rx2A-2fbmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 8 ALA A 308
ILE A 392
GLY A 393
GLY A 395
ILE A 398
 None
 1.27A 1sguA-2fbmA:
undetectable		 1sguA-2fbmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 8 ALA A 308
ILE A 392
GLY A 393
ILE A 398
ALA A 336
 None
 1.25A 1sguA-2fbmA:
undetectable		 1sguA-2fbmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 12 ILE A 286
ILE A 383
LEU A 321
ILE A 297
THR A 301
 None
 0.96A 2d0kA-2fbmA:
undetectable		 2d0kA-2fbmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 12 ILE A 286
ILE A 383
LEU A 321
ILE A 297
THR A 301
 None
 0.98A 2d0kB-2fbmA:
undetectable		 2d0kB-2fbmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 12 ILE A 286
ALA A 336
ILE A 383
LEU A 321
ILE A 297
 None
 1.06A 2drcB-2fbmA:
undetectable		 2drcB-2fbmA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 12 LEU A 321
ILE A 314
ILE A 317
PHE A 376
VAL A 385
 None
 1.08A 2ygoA-2fbmA:
undetectable		 2ygoA-2fbmA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 12 ILE A 286
ALA A 336
ILE A 383
LEU A 321
ILE A 297
 None
 1.04A 3drcB-2fbmA:
undetectable		 3drcB-2fbmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 11 ASP A 425
PHE A 372
LEU A 401
ILE A 398
SER A 397
 None
 1.14A 3o94B-2fbmA:
undetectable		 3o94B-2fbmA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		4 / 5 LYS A 315
THR A 311
ILE A 314
PHE A 350
 None
 1.34A 3tf1A-2fbmA:
undetectable		 3tf1A-2fbmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 12 ILE A 286
ALA A 336
ILE A 383
LEU A 321
ILE A 297
 None
 1.04A 4dfrB-2fbmA:
undetectable		 4dfrB-2fbmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 12 GLY A 344
VAL A 318
PHE A 334
ILE A 398
PHE A 341
 None
 1.04A 4fglA-2fbmA:
undetectable
4fglB-2fbmA:
undetectable		 4fglA-2fbmA:
22.68
4fglB-2fbmA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		5 / 10 ALA A 453
THR A 452
ALA A 456
VAL A 465
GLY A 389
 None
 1.04A 4qvyY-2fbmA:
undetectable
4qvyZ-2fbmA:
undetectable		 4qvyY-2fbmA:
19.19
4qvyZ-2fbmA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2fbm Y CHROMOSOME
CHROMODOMAIN PROTEIN
1, TELOMERIC ISOFORM
B
(Homo
sapiens) 		4 / 8 LYS A 494
ALA A 495
ASP A 403
ASN A 486
 None
 0.86A 5mvsB-2fbmA:
undetectable		 5mvsB-2fbmA:
22.35