SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fbo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3
(Branchiostoma
floridae) 		4 / 7 LEU J  94
LEU J  24
THR J   9
VAL J   7
 None
 0.87A 1dvxB-2fboJ:
undetectable		 1dvxB-2fboJ:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3
(Branchiostoma
floridae) 		5 / 11 SER J 247
VAL J 230
GLU J 119
GLY J 121
LEU J 122
 None
 1.41A 1i9jH-2fboJ:
12.5
1i9jL-2fboJ:
5.4		 1i9jH-2fboJ:
20.22
1i9jL-2fboJ:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3
(Branchiostoma
floridae) 		4 / 8 VAL J  99
LEU J 129
PRO J 101
GLU J  15
 None
 1.07A 1jtvA-2fboJ:
undetectable		 1jtvA-2fboJ:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3
(Branchiostoma
floridae) 		3 / 3 SER J 202
GLU J 119
ASP J 123
 None
 0.83A 2zulA-2fboJ:
undetectable		 2zulA-2fboJ:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3
(Branchiostoma
floridae) 		3 / 3 ARG J 106
VAL J 131
THR J 135
 None
 0.76A 3cyxA-2fboJ:
undetectable		 3cyxA-2fboJ:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3
(Branchiostoma
floridae) 		4 / 7 LEU J  94
LEU J  24
THR J   9
VAL J   7
 None
 0.88A 3d2tA-2fboJ:
undetectable		 3d2tA-2fboJ:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3
(Branchiostoma
floridae) 		3 / 3 SER J 202
GLU J 119
ASP J 123
 None
 0.82A 3dmhA-2fboJ:
undetectable		 3dmhA-2fboJ:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3
(Branchiostoma
floridae) 		3 / 3 ILE J 116
ASP J  33
ARG J 229
 None
 0.84A 4pstA-2fboJ:
undetectable		 4pstA-2fboJ:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSG_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3
(Branchiostoma
floridae) 		5 / 9 GLU J 183
VAL J  38
GLY J 185
GLN J 110
LEU J 122
 None
 1.47A 5ksgB-2fboJ:
undetectable		 5ksgB-2fboJ:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3
(Branchiostoma
floridae) 		5 / 9 GLU J 183
VAL J  38
GLY J 185
GLN J 110
LEU J 122
 None
 1.47A 5ksnB-2fboJ:
undetectable		 5ksnB-2fboJ:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB805_1
(CATALASE-PEROXIDASE)		 2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3
(Branchiostoma
floridae) 		5 / 9 GLU J 183
VAL J  38
GLY J 185
GLN J 110
LEU J 122
 None
 1.48A 5syiB-2fboJ:
undetectable		 5syiB-2fboJ:
16.52