SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fbq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 8 GLU A  71
ARG A  74
ARG A  75
LEU A  92
 None
 0.81A 1cmaA-2fbqA:
undetectable
1cmaB-2fbqA:
undetectable		 1cmaA-2fbqA:
20.75
1cmaB-2fbqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 10 GLU A  71
ARG A  74
ARG A  75
LEU A  92
ALA A  99
 None
 1.24A 1cmcA-2fbqA:
undetectable
1cmcB-2fbqA:
undetectable		 1cmcA-2fbqA:
20.75
1cmcB-2fbqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  99
GLU A  71
ARG A  74
ARG A  75
LEU A  92
 None
 1.24A 1mj2C-2fbqA:
undetectable
1mj2D-2fbqA:
undetectable		 1mj2C-2fbqA:
20.28
1mj2D-2fbqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  99
GLU A  71
ARG A  74
ARG A  75
LEU A  92
 None
 1.23A 1mjoC-2fbqA:
undetectable
1mjoD-2fbqA:
undetectable		 1mjoC-2fbqA:
20.28
1mjoD-2fbqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 115
PHE A 111
MET A 196
ALA A  97
PHE A  64
 None
 1.39A 2jj8B-2fbqA:
undetectable		 2jj8B-2fbqA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 VAL A  42
ILE A  31
ALA A  35
VAL A  37
 None
 0.67A 2xrzB-2fbqA:
undetectable		 2xrzB-2fbqA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 6 VAL A   7
LEU A 126
ALA A  55
LEU A  11
 None
 0.91A 3kk6B-2fbqA:
undetectable		 3kk6B-2fbqA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 9 MET A 199
PHE A 203
ALA A 167
ALA A 169
LEU A 108
 None
 1.41A 3l4dB-2fbqA:
0.9		 3l4dB-2fbqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 ALA A 148
GLU A  87
ALA A 204
MET A 164
 None
 1.46A 3r9tC-2fbqA:
undetectable		 3r9tC-2fbqA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 THR A   6
ARG A   9
LEU A  52
SER A  27
 None
 1.26A 5uxcA-2fbqA:
undetectable		 5uxcA-2fbqA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 ARG A  59
GLU A  15
ASP A  12
GLU A   5
 None
 1.21A 6mn5B-2fbqA:
undetectable		 6mn5B-2fbqA:
18.22