SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fbv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		4 / 8 ASP A 143
ASP A  82
GLY A  80
THR A 162
 MN  A 237 ( 4.2A)
MN  A 238 ( 2.8A)
None
None
 0.86A 1m4iA-2fbvA:
undetectable		 1m4iA-2fbvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		5 / 12 SER A  52
PHE A  49
VAL A  54
ALA A 217
ALA A 214
 None
 1.10A 1n5xA-2fbvA:
undetectable		 1n5xA-2fbvA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		5 / 12 SER A  52
PHE A  49
VAL A  54
ALA A 217
ALA A 214
 None
 1.10A 1n5xB-2fbvA:
undetectable		 1n5xB-2fbvA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		5 / 12 LEU A 161
GLY A  80
CYH A 109
ALA A 217
ALA A 214
 None
 1.06A 2bm9C-2fbvA:
undetectable		 2bm9C-2fbvA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		5 / 12 LEU A 161
GLY A  80
CYH A 109
ALA A 217
ALA A 214
 None
 1.10A 2bm9D-2fbvA:
undetectable		 2bm9D-2fbvA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		5 / 12 LEU A 161
GLY A  80
CYH A 109
ALA A 217
ALA A 214
 None
 1.11A 2br4A-2fbvA:
undetectable		 2br4A-2fbvA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		5 / 12 LEU A 161
GLY A  80
CYH A 109
ALA A 217
ALA A 214
 None
 1.11A 2br4B-2fbvA:
undetectable		 2br4B-2fbvA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		5 / 12 LEU A 161
GLY A  80
CYH A 109
ALA A 217
ALA A 214
 None
 1.14A 2br4C-2fbvA:
undetectable		 2br4C-2fbvA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		5 / 12 LEU A 161
GLY A  80
CYH A 109
ALA A 217
ALA A 214
 None
 1.12A 2br4D-2fbvA:
undetectable		 2br4D-2fbvA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		5 / 12 VAL A 133
PHE A 151
ILE A 153
VAL A  97
LEU A 102
 None
 1.25A 2ft9A-2fbvA:
undetectable		 2ft9A-2fbvA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		4 / 8 SER A  66
LEU A 124
LEU A 102
ASP A  68
 None
 1.02A 2j2pA-2fbvA:
undetectable
2j2pB-2fbvA:
undetectable		 2j2pA-2fbvA:
21.49
2j2pB-2fbvA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		4 / 5 ILE A 223
LEU A 161
ASP A  82
ALA A 219
 None
None
MN  A 238 ( 2.8A)
None
 0.99A 2opxA-2fbvA:
undetectable		 2opxA-2fbvA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		4 / 8 SER A  52
PHE A  49
VAL A  54
ALA A 214
 None
 1.01A 3ax7A-2fbvA:
1.3		 3ax7A-2fbvA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		4 / 8 SER A  52
PHE A  49
VAL A  54
ALA A 214
 None
 1.01A 3ax9A-2fbvA:
undetectable		 3ax9A-2fbvA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		4 / 7 PHE A 120
VAL A 114
PHE A 112
ILE A  69
 None
 0.90A 3zjqA-2fbvA:
undetectable		 3zjqA-2fbvA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		4 / 7 PHE A 120
VAL A 114
PHE A 112
ILE A  69
 None
 0.89A 3zjqB-2fbvA:
undetectable		 3zjqB-2fbvA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		3 / 3 SER A 116
ALA A  98
VAL A  97
 None
 0.49A 4x20C-2fbvA:
undetectable		 4x20C-2fbvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		4 / 7 GLY A 139
LEU A 124
PHE A 112
PHE A 151
 None
 0.64A 5hieB-2fbvA:
undetectable		 5hieB-2fbvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		4 / 8 ASP A  82
VAL A 181
ILE A 223
ILE A 140
 MN  A 238 ( 2.8A)
None
None
None
 0.96A 5hw8H-2fbvA:
undetectable		 5hw8H-2fbvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		5 / 10 ILE A 100
LEU A 124
GLY A  80
ALA A 217
PHE A  81
 None
 1.15A 5mxbA-2fbvA:
undetectable		 5mxbA-2fbvA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens) 		5 / 10 ILE A 100
LEU A 124
PHE A 112
GLY A  80
PHE A  81
 None
 1.12A 5mxbA-2fbvA:
undetectable		 5mxbA-2fbvA:
17.68