SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2fc3 50S RIBOSOMAL
PROTEIN L7AE
(Aeropyrum
pernix) 		5 / 9 HIS A  65
THR A  39
THR A  40
SER A  98
ALA A  97
 None
 1.23A 1gtnQ-2fc3A:
undetectable
1gtnR-2fc3A:
undetectable		 1gtnQ-2fc3A:
21.31
1gtnR-2fc3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 2fc3 50S RIBOSOMAL
PROTEIN L7AE
(Aeropyrum
pernix) 		4 / 8 ARG A  85
ALA A  89
GLU A  17
VAL A  52
 None
 0.70A 2bxgA-2fc3A:
undetectable		 2bxgA-2fc3A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2fc3 50S RIBOSOMAL
PROTEIN L7AE
(Aeropyrum
pernix) 		4 / 8 GLU A  17
GLU A  21
LYS A  24
ARG A  25
 None
 1.06A 4bqfB-2fc3A:
undetectable		 4bqfB-2fc3A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 2fc3 50S RIBOSOMAL
PROTEIN L7AE
(Aeropyrum
pernix) 		5 / 12 ILE A 101
ASP A  71
ARG A 122
LEU A  66
PRO A  67
 None
 0.97A 4m2xE-2fc3A:
undetectable		 4m2xE-2fc3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 2fc3 50S RIBOSOMAL
PROTEIN L7AE
(Aeropyrum
pernix) 		4 / 8 ALA A  48
ILE A  75
LEU A  66
SER A  98
 None
 0.77A 4wboB-2fc3A:
undetectable		 4wboB-2fc3A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 2fc3 50S RIBOSOMAL
PROTEIN L7AE
(Aeropyrum
pernix) 		5 / 12 THR A  39
ALA A 100
LEU A  50
ILE A  92
GLY A  87
 None
 1.02A 4xi3B-2fc3A:
undetectable		 4xi3B-2fc3A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 2fc3 50S RIBOSOMAL
PROTEIN L7AE
(Aeropyrum
pernix) 		3 / 3 THR A  36
ALA A  97
LYS A  83
 None
 0.69A 6fgcA-2fc3A:
undetectable		 6fgcA-2fc3A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 2fc3 50S RIBOSOMAL
PROTEIN L7AE
(Aeropyrum
pernix) 		3 / 3 THR A  36
ALA A  97
LYS A  83
 None
 0.70A 6fgdA-2fc3A:
undetectable		 6fgdA-2fc3A:
15.71