SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		5 / 9 ASN A 115
GLU A 192
ILE A  53
ALA A  57
THR A  47
 None
 1.46A 1aj6A-2fcaA:
undetectable		 1aj6A-2fcaA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		4 / 8 GLU A  44
GLY A  46
GLU A  69
ASP A  96
 None
K  A 250 (-3.9A)
None
None
 0.79A 1jg4A-2fcaA:
7.1		 1jg4A-2fcaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		3 / 3 VAL A 103
VAL A 142
TRP A  31
 None
 0.97A 1w5uC-2fcaA:
undetectable
1w5uD-2fcaA:
undetectable		 1w5uC-2fcaA:
7.74
1w5uD-2fcaA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		3 / 3 VAL A 142
TRP A  31
VAL A 103
 None
 0.88A 2izqA-2fcaA:
undetectable
2izqB-2fcaA:
undetectable		 2izqA-2fcaA:
7.74
2izqB-2fcaA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		6 / 12 GLY A  46
GLY A  48
GLU A  69
ALA A  97
PHE A 116
THR A 191
 K  A 250 (-3.9A)
None
None
None
None
None
 0.69A 2vdvE-2fcaA:
17.6		 2vdvE-2fcaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		6 / 12 GLY A  46
GLY A  48
GLU A  69
PHE A 116
ASP A 118
THR A 191
 K  A 250 (-3.9A)
None
None
None
None
None
 0.70A 2vdvE-2fcaA:
17.6		 2vdvE-2fcaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		6 / 11 GLY A  46
GLY A  48
GLU A  69
ALA A  97
PHE A 116
THR A 191
 K  A 250 (-3.9A)
None
None
None
None
None
 0.69A 2vdvF-2fcaA:
17.6		 2vdvF-2fcaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		6 / 11 GLY A  46
GLY A  48
GLU A  69
PHE A 116
ASP A 118
THR A 191
 K  A 250 (-3.9A)
None
None
None
None
None
 0.70A 2vdvF-2fcaA:
17.6		 2vdvF-2fcaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 PHE A  35
PRO A  24
VAL A 103
LEU A 100
ILE A  43
 None
 1.29A 2xrlA-2fcaA:
undetectable		 2xrlA-2fcaA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLY A  46
GLY A  48
GLU A  69
ASP A 118
THR A 191
 K  A 250 (-3.9A)
None
None
None
None
 0.66A 3ckkA-2fcaA:
18.7		 3ckkA-2fcaA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		6 / 11 GLU A  44
GLY A  46
GLU A  69
ALA A  97
PHE A 116
ASP A 118
 None
K  A 250 (-3.9A)
None
None
None
None
 0.76A 3dxyA-2fcaA:
23.8		 3dxyA-2fcaA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		6 / 11 GLU A  44
GLY A  46
GLU A  69
ASP A  96
ALA A  97
PHE A 116
 None
K  A 250 (-3.9A)
None
None
None
None
 1.16A 3dxyA-2fcaA:
23.8		 3dxyA-2fcaA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		7 / 11 GLU A  44
GLY A  46
GLY A  48
ILE A  68
GLU A  69
ASP A  96
PHE A 116
 None
K  A 250 (-3.9A)
None
None
None
None
None
 0.76A 3dxyA-2fcaA:
23.8		 3dxyA-2fcaA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		7 / 11 GLU A  44
GLY A  46
GLY A  48
ILE A  68
GLU A  69
PHE A 116
ASP A 118
 None
K  A 250 (-3.9A)
None
None
None
None
None
 0.52A 3dxyA-2fcaA:
23.8		 3dxyA-2fcaA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		6 / 12 VAL A  45
GLY A  46
GLY A  48
GLU A  69
ASP A  96
ALA A  97
 None
K  A 250 (-3.9A)
None
None
None
None
 1.04A 3fuuA-2fcaA:
9.8		 3fuuA-2fcaA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		5 / 11 GLY A  46
THR A 191
GLU A  69
ASP A  96
ALA A  97
 K  A 250 (-3.9A)
None
None
None
None
 1.08A 3id5B-2fcaA:
11.7		 3id5B-2fcaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		5 / 11 GLY A  46
THR A 191
GLU A  69
ASP A  96
ALA A  97
 K  A 250 (-3.9A)
None
None
None
None
 1.08A 3id5F-2fcaA:
11.6		 3id5F-2fcaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		3 / 3 VAL A 103
VAL A 142
TRP A  31
 None
 0.92A 3l8lA-2fcaA:
undetectable
3l8lB-2fcaA:
undetectable		 3l8lA-2fcaA:
7.74
3l8lB-2fcaA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		3 / 3 VAL A 103
VAL A 142
TRP A  31
 None
 0.97A 3l8lC-2fcaA:
undetectable
3l8lD-2fcaA:
undetectable		 3l8lC-2fcaA:
7.74
3l8lD-2fcaA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		4 / 7 ILE A  21
LEU A  93
PHE A 104
LYS A 110
 None
 0.80A 4hajA-2fcaA:
undetectable		 4hajA-2fcaA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLY A  46
GLY A  48
LEU A  70
ASP A  96
ALA A  97
 K  A 250 (-3.9A)
None
None
None
None
 1.01A 4krhA-2fcaA:
12.3		 4krhA-2fcaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLY A  46
GLY A  48
GLY A  50
LEU A  70
ALA A  97
 K  A 250 (-3.9A)
None
None
None
None
 0.96A 4uciA-2fcaA:
6.7		 4uciA-2fcaA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLY A  46
GLY A  48
GLY A  50
LEU A  70
ALA A  97
 K  A 250 (-3.9A)
None
None
None
None
 0.96A 4uciB-2fcaA:
6.7		 4uciB-2fcaA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 THR A 191
GLY A  46
GLY A  48
GLY A  50
LEU A  70
 None
K  A 250 (-3.9A)
None
None
None
 1.01A 4uciB-2fcaA:
6.7		 4uciB-2fcaA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		4 / 7 THR A 131
LEU A 130
LEU A 114
THR A 153
 None
 0.92A 4z90A-2fcaA:
undetectable
4z90B-2fcaA:
undetectable
4z90C-2fcaA:
undetectable
4z90D-2fcaA:
undetectable
4z90E-2fcaA:
undetectable		 4z90A-2fcaA:
20.18
4z90B-2fcaA:
20.18
4z90C-2fcaA:
20.18
4z90D-2fcaA:
20.18
4z90E-2fcaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		4 / 6 THR A  47
GLY A  67
GLU A  44
ILE A  41
 None
 0.96A 5kmfA-2fcaA:
undetectable
5kmfC-2fcaA:
undetectable		 5kmfA-2fcaA:
21.80
5kmfC-2fcaA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		5 / 11 VAL A  45
GLY A  46
GLU A  69
ASP A  96
ALA A  97
 None
K  A 250 (-3.9A)
None
None
None
 1.10A 5x6yA-2fcaA:
5.3		 5x6yA-2fcaA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		5 / 10 VAL A  45
GLY A  46
GLU A  69
ALA A  97
LEU A 130
 None
K  A 250 (-3.9A)
None
None
None
 0.93A 5x6yB-2fcaA:
3.1		 5x6yB-2fcaA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		5 / 10 VAL A  45
GLY A  46
GLU A  69
ASP A  96
ALA A  97
 None
K  A 250 (-3.9A)
None
None
None
 1.09A 5x6yB-2fcaA:
3.1		 5x6yB-2fcaA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		5 / 11 VAL A  45
GLY A  46
GLU A  69
ASP A  96
ALA A  97
 None
K  A 250 (-3.9A)
None
None
None
 1.03A 5x6yC-2fcaA:
2.4		 5x6yC-2fcaA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		3 / 3 THR A 101
GLU A 141
HIS A 134
 None
 0.89A 5xioA-2fcaA:
undetectable		 5xioA-2fcaA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Bacillus
subtilis) 		3 / 3 THR A 101
GLU A 141
HIS A 134
 None
 0.86A 5xiqB-2fcaA:
undetectable		 5xiqB-2fcaA:
18.20