SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fcc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 2fcc ENDONUCLEASE V
(Escherichia
virus
T4) 		4 / 6 LEU A  67
GLN A  71
GLU A  73
ILE A  72
 None
None
GOL  A 602 (-3.4A)
None
 0.91A 2fcnA-2fccA:
undetectable
2fcnB-2fccA:
undetectable		 2fcnA-2fccA:
19.85
2fcnB-2fccA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 2fcc ENDONUCLEASE V
(Escherichia
virus
T4) 		3 / 3 TYR A 104
ASP A  62
HIS A  56
 SO4  A 501 (-4.8A)
None
None
 0.97A 3e23A-2fccA:
undetectable		 3e23A-2fccA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2fcc ENDONUCLEASE V
(Escherichia
virus
T4) 		4 / 8 ARG A  70
GLU A  77
LYS A  80
ARG A  81
 GOL  A 602 (-3.9A)
None
None
None
 0.95A 4bqfB-2fccA:
undetectable		 4bqfB-2fccA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2fcc ENDONUCLEASE V
(Escherichia
virus
T4) 		5 / 12 GLY A  55
LEU A  24
ILE A  72
PHE A  28
THR A  58
 None
 1.11A 4ze2A-2fccA:
undetectable		 4ze2A-2fccA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2fcc ENDONUCLEASE V
(Escherichia
virus
T4) 		5 / 12 GLY A  55
LEU A  24
ILE A  72
PHE A  28
THR A  58
 None
 1.17A 5eskA-2fccA:
undetectable		 5eskA-2fccA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2fcc ENDONUCLEASE V
(Escherichia
virus
T4) 		5 / 12 ALA A  19
ILE A  85
LEU A  17
LEU A  12
LEU A  74
 None
 1.21A 5nfjC-2fccA:
undetectable		 5nfjC-2fccA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2fcc ENDONUCLEASE V
(Escherichia
virus
T4) 		3 / 3 ARG A 125
LYS A 121
ARG A  70
 None
SO4  A 502 (-3.0A)
GOL  A 602 (-3.9A)
 0.93A 6c06D-2fccA:
undetectable		 6c06D-2fccA:
undetectable