SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fcf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2fcf MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 12 ALA A1196
VAL A1239
ASN A1199
GLY A1163
ILE A1164
 None
 1.18A 2dcfA-2fcfA:
undetectable		 2dcfA-2fcfA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2fcf MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 11 GLY A1163
ILE A1164
SER A1165
VAL A1225
ARG A1229
 None
 0.73A 2kawA-2fcfA:
11.8		 2kawA-2fcfA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2fcf MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		6 / 11 LEU A1162
GLY A1163
ILE A1164
SER A1165
ILE A1166
VAL A1225
 None
 0.94A 2kawA-2fcfA:
11.8		 2kawA-2fcfA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2fcf MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 12 ALA A1196
VAL A1239
ASN A1199
GLY A1163
ILE A1164
 None
 1.21A 3a65A-2fcfA:
undetectable		 3a65A-2fcfA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2fcf MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		4 / 6 LYS A1203
VAL A1209
VAL A1152
ILE A1187
 None
 1.15A 3mssC-2fcfA:
undetectable		 3mssC-2fcfA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2fcf MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A1228
ALA A1224
PHE A1237
SER A1165
VAL A1235
 None
 1.22A 5i75A-2fcfA:
undetectable		 5i75A-2fcfA:
11.07