SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fcj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2fcj SMALL TOPRIM DOMAIN
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 GLN A  17
ILE A  82
HIS A  96
 None
 0.76A 1fm9A-2fcjA:
undetectable		 1fm9A-2fcjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2fcj SMALL TOPRIM DOMAIN
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 GLN A  17
ILE A  82
HIS A  96
 None
 0.74A 1k74A-2fcjA:
undetectable		 1k74A-2fcjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 2fcj SMALL TOPRIM DOMAIN
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A  41
PHE A  74
PRO A  75
ALA A  77
 None
 1.46A 3vm4A-2fcjA:
undetectable		 3vm4A-2fcjA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2fcj SMALL TOPRIM DOMAIN
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  66
VAL A  10
LEU A 101
VAL A 100
VAL A  53
 None
 1.13A 4ib4A-2fcjA:
undetectable		 4ib4A-2fcjA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2fcj SMALL TOPRIM DOMAIN
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A  30
LEU A  44
PHE A  74
VAL A  53
HIS A  79
 None
 1.06A 5om2A-2fcjA:
undetectable
5om2B-2fcjA:
undetectable		 5om2A-2fcjA:
20.16
5om2B-2fcjA:
10.08