SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YC2_E_NCAE507_0 (NAD-DEPENDENT DEACETYLASE 2)	2fco	RECOMBINATION PROTEIN U (PENICILLIN-BINDING PROTEIN RELATED FACTOR A) (Geobacillus kaustophilus)	4 / 7	LEU A 37 ASN A 88 ILE A 96 ASP A 97	None	0.93A	1yc2E-2fcoA: undetectable	1yc2E-2fcoA: 19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z11_C_8MOC501_0 (CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6)	2fco	RECOMBINATION PROTEIN U (PENICILLIN-BINDING PROTEIN RELATED FACTOR A) (Geobacillus kaustophilus)	5 / 10	PHE A 98 VAL A 193 ILE A 52 THR A 40 ILE A 187	None	1.08A	1z11C-2fcoA: undetectable	1z11C-2fcoA: 18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z11_D_8MOD501_0 (CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6)	2fco	RECOMBINATION PROTEIN U (PENICILLIN-BINDING PROTEIN RELATED FACTOR A) (Geobacillus kaustophilus)	5 / 10	PHE A 98 VAL A 193 ILE A 52 THR A 40 ILE A 187	None	1.10A	1z11D-2fcoA: undetectable	1z11D-2fcoA: 18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CLD_B_GW6B2_2 (GLUCOCORTICOID RECEPTOR)	2fco	RECOMBINATION PROTEIN U (PENICILLIN-BINDING PROTEIN RELATED FACTOR A) (Geobacillus kaustophilus)	4 / 8	ALA A 149 LEU A 152 TYR A 87 ILE A 187	None	0.93A	3cldB-2fcoA: undetectable	3cldB-2fcoA: 19.92

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1YC2_E_NCAE507_0","NAD-DEPENDENT DEACETYLASE 2","2fco","RECOMBINATION PROTEIN U (PENICILLIN-BINDING PROTEIN RELATED FACTOR A)","Geobacillus kaustophilus",4,"LEU A  37;ASN A  88;ILE A  96;ASP A  97","None","0.93A","1yc2E-2fcoA:undetectable","1yc2E-2fcoA:19.37"],["1Z11_C_8MOC501_0","CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6","2fco","RECOMBINATION PROTEIN U (PENICILLIN-BINDING PROTEIN RELATED FACTOR A)","Geobacillus kaustophilus",5,"PHE A  98;VAL A 193;ILE A  52;THR A  40;ILE A 187","None","1.08A","1z11C-2fcoA:undetectable","1z11C-2fcoA:18.86"],["1Z11_D_8MOD501_0","CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6","2fco","RECOMBINATION PROTEIN U (PENICILLIN-BINDING PROTEIN RELATED FACTOR A)","Geobacillus kaustophilus",5,"PHE A  98;VAL A 193;ILE A  52;THR A  40;ILE A 187","None","1.10A","1z11D-2fcoA:undetectable","1z11D-2fcoA:18.86"],["3CLD_B_GW6B2_2","GLUCOCORTICOID RECEPTOR","2fco","RECOMBINATION PROTEIN U (PENICILLIN-BINDING PROTEIN RELATED FACTOR A)","Geobacillus kaustophilus",4,"ALA A 149;LEU A 152;TYR A  87;ILE A 187","None","0.93A","3cldB-2fcoA:undetectable","3cldB-2fcoA:19.92"]]