SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fcr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 2fcr FLAVODOXIN
(Chondrus
crispus) 		6 / 7 THR A  10
ASN A  12
THR A  55
GLY A  93
ASP A  94
TYR A  98
 FMN  A 174 (-3.6A)
FMN  A 174 (-3.5A)
FMN  A 174 (-3.8A)
FMN  A 174 (-3.1A)
None
FMN  A 174 (-3.4A)
 0.51A 1bu5A-2fcrA:
19.5		 1bu5A-2fcrA:
31.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 2fcr FLAVODOXIN
(Chondrus
crispus) 		5 / 7 THR A  55
TRP A  56
GLY A  93
ASP A  94
TYR A  98
 FMN  A 174 (-3.8A)
FMN  A 174 (-3.9A)
FMN  A 174 (-3.1A)
None
FMN  A 174 (-3.4A)
 0.74A 1bu5A-2fcrA:
19.5		 1bu5A-2fcrA:
31.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2fcr FLAVODOXIN
(Chondrus
crispus) 		6 / 8 THR A  10
ASN A  12
THR A  55
GLY A  93
ASP A  94
TYR A  98
 FMN  A 174 (-3.6A)
FMN  A 174 (-3.5A)
FMN  A 174 (-3.8A)
FMN  A 174 (-3.1A)
None
FMN  A 174 (-3.4A)
 0.52A 1bu5B-2fcrA:
19.4		 1bu5B-2fcrA:
31.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2fcr FLAVODOXIN
(Chondrus
crispus) 		5 / 8 THR A  55
TRP A  56
GLY A  93
ASP A  94
TYR A  98
 FMN  A 174 (-3.8A)
FMN  A 174 (-3.9A)
FMN  A 174 (-3.1A)
None
FMN  A 174 (-3.4A)
 0.78A 1bu5B-2fcrA:
19.4		 1bu5B-2fcrA:
31.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2fcr FLAVODOXIN
(Chondrus
crispus) 		4 / 5 LEU A  51
PRO A 120
VAL A  87
ILE A  89
 None
 0.97A 2aoiB-2fcrA:
undetectable		 2aoiB-2fcrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2fcr FLAVODOXIN
(Chondrus
crispus) 		4 / 6 LEU A  49
VAL A  87
LEU A  77
ASP A 111
 None
 0.84A 3cs9D-2fcrA:
undetectable		 3cs9D-2fcrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2fcr FLAVODOXIN
(Chondrus
crispus) 		3 / 3 CYH A 103
PRO A  99
ASP A 148
 FMN  A 174 (-4.3A)
None
None
 0.86A 3hlwB-2fcrA:
undetectable		 3hlwB-2fcrA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 2fcr FLAVODOXIN
(Chondrus
crispus) 		5 / 9 SER A   9
THR A   8
THR A  13
ASN A  12
ASP A 148
 FMN  A 174 (-4.4A)
FMN  A 174 (-3.6A)
FMN  A 174 (-3.5A)
FMN  A 174 (-3.5A)
None
 1.49A 3sfuA-2fcrA:
undetectable		 3sfuA-2fcrA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2fcr FLAVODOXIN
(Chondrus
crispus) 		5 / 12 GLY A  91
GLY A  52
LEU A  24
VAL A 160
ALA A 161
 None
 1.18A 3t7vA-2fcrA:
undetectable		 3t7vA-2fcrA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2fcr FLAVODOXIN
(Chondrus
crispus) 		3 / 3 ASP A  29
LEU A  49
VAL A 164
 None
 0.66A 4jecB-2fcrA:
undetectable		 4jecB-2fcrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2fcr FLAVODOXIN
(Chondrus
crispus) 		3 / 3 ASP A  29
LEU A  49
VAL A 168
 None
 0.50A 4jecB-2fcrA:
undetectable		 4jecB-2fcrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 2fcr FLAVODOXIN
(Chondrus
crispus) 		4 / 5 PHE A   5
THR A  38
PHE A  72
ILE A  32
 None
 1.15A 4jx1E-2fcrA:
undetectable		 4jx1E-2fcrA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 2fcr FLAVODOXIN
(Chondrus
crispus) 		3 / 3 CYH A 103
PRO A  99
ASP A 148
 FMN  A 174 (-4.3A)
None
None
 0.78A 4pm5A-2fcrA:
undetectable		 4pm5A-2fcrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 2fcr FLAVODOXIN
(Chondrus
crispus) 		5 / 11 LEU A  77
ASP A  33
VAL A  37
ILE A  32
GLY A   3
 None
 0.96A 4rvjA-2fcrA:
undetectable		 4rvjA-2fcrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 2fcr FLAVODOXIN
(Chondrus
crispus) 		5 / 11 LEU A  77
ASP A  33
VAL A  37
ILE A  32
GLY A   3
 None
 0.95A 4rvjC-2fcrA:
undetectable		 4rvjC-2fcrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2fcr FLAVODOXIN
(Chondrus
crispus) 		3 / 3 GLY A  97
ASP A  94
ASN A  12
 None
None
FMN  A 174 (-3.5A)
 0.56A 5jglA-2fcrA:
undetectable		 5jglA-2fcrA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 2fcr FLAVODOXIN
(Chondrus
crispus) 		5 / 12 PRO A 146
GLY A 144
ASP A 104
ASN A 101
ASP A  61
 None
 1.24A 5yniA-2fcrA:
undetectable		 5yniA-2fcrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 2fcr FLAVODOXIN
(Chondrus
crispus) 		5 / 12 PRO A 146
GLY A 144
ASP A 104
ASN A 101
ASP A  61
 None
 1.25A 5ynmA-2fcrA:
undetectable		 5ynmA-2fcrA:
18.75