SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fct'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2
(Pseudomonas
syringae) 		4 / 8 ALA A 124
GLU A 271
ARG A 100
LEU A 203
 None
 0.97A 1ereE-2fctA:
undetectable		 1ereE-2fctA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2
(Pseudomonas
syringae) 		4 / 8 ALA A 124
GLU A 271
ARG A 100
LEU A 203
 None
 0.98A 1ereF-2fctA:
undetectable		 1ereF-2fctA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2
(Pseudomonas
syringae) 		4 / 7 ALA A  26
TYR A  27
ARG A  81
PHE A 148
 None
 0.91A 2ajvH-2fctA:
undetectable
2ajvL-2fctA:
undetectable		 2ajvH-2fctA:
19.22
2ajvL-2fctA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2
(Pseudomonas
syringae) 		5 / 12 PHE A  24
ALA A 147
ILE A 228
ILE A  21
LEU A 158
 None
 1.19A 2bjfA-2fctA:
undetectable		 2bjfA-2fctA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2
(Pseudomonas
syringae) 		5 / 12 PHE A  24
ALA A 147
ILE A 228
ILE A  21
LEU A 158
 None
 1.16A 2rlcA-2fctA:
undetectable		 2rlcA-2fctA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2
(Pseudomonas
syringae) 		4 / 7 PHE A 148
GLY A 224
THR A 146
PHE A  74
 None
 1.01A 4ejjB-2fctA:
undetectable		 4ejjB-2fctA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2
(Pseudomonas
syringae) 		4 / 8 ILE A  91
LEU A   7
ILE A  84
PHE A  24
 None
 0.85A 4hb6A-2fctA:
undetectable		 4hb6A-2fctA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2
(Pseudomonas
syringae) 		4 / 8 ILE A  91
LEU A   7
ILE A  84
PHE A  24
 None
 0.82A 4hb8A-2fctA:
undetectable		 4hb8A-2fctA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2
(Pseudomonas
syringae) 		3 / 3 LYS A 106
ARG A 248
TRP A 145
 AKG  A 897 (-4.2A)
AKG  A 897 (-2.8A)
AKG  A 897 (-4.0A)
 0.89A 4i90A-2fctA:
undetectable		 4i90A-2fctA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2
(Pseudomonas
syringae) 		3 / 3 GLY A 112
PRO A 239
GLN A 159
 None
 0.55A 4oltB-2fctA:
undetectable		 4oltB-2fctA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2
(Pseudomonas
syringae) 		4 / 6 LEU A 203
PHE A 195
TYR A 272
GLU A 271
 None
 0.99A 4pahA-2fctA:
undetectable		 4pahA-2fctA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2
(Pseudomonas
syringae) 		4 / 6 GLU A 102
THR A 120
TYR A 272
PHE A 104
 None
None
None
AKG  A 897 (-3.6A)
 1.21A 5lrbA-2fctA:
undetectable		 5lrbA-2fctA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2
(Pseudomonas
syringae) 		3 / 3 THR A 232
MET A 234
HIS A 235
 DSU  A 896 (-2.9A)
CL  A 903 ( 4.4A)
FE2  A 900 (-3.4A)
 0.83A 5uunA-2fctA:
undetectable		 5uunA-2fctA:
24.51