SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fcw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2fcw ALPHA-2-MACROGLOBULI
N
RECEPTOR-ASSOCIATED
PROTEIN
LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS A 289
ASP B 118
ASP B  97
 None
CA  B3001 (-3.3A)
None
 1.06A 2br4A-2fcwA:
undetectable		 2br4A-2fcwA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 2fcw ALPHA-2-MACROGLOBULI
N
RECEPTOR-ASSOCIATED
PROTEIN
LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens;
Homo
sapiens) 		4 / 8 ILE B 101
SER B 102
SER A 286
ARG A 285
 None
 0.94A 2cdqA-2fcwB:
undetectable		 2cdqA-2fcwB:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 2fcw ALPHA-2-MACROGLOBULI
N
RECEPTOR-ASSOCIATED
PROTEIN
(Homo
sapiens) 		4 / 6 LYS A 289
LEU A 293
GLU A 294
LEU A 264
 None
 0.94A 3h5gA-2fcwA:
undetectable
3h5gC-2fcwA:
undetectable		 3h5gA-2fcwA:
16.67
3h5gC-2fcwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2fcw ALPHA-2-MACROGLOBULI
N
RECEPTOR-ASSOCIATED
PROTEIN
LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens;
Homo
sapiens) 		3 / 3 PRO B 150
ASP B 149
GLU A 299
 None
 0.81A 3v4tC-2fcwB:
undetectable		 3v4tC-2fcwB:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 2fcw LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 6 ASP B 112
ASP B 118
ALA B 120
ASP B 108
 CA  B3001 (-3.3A)
CA  B3001 (-3.3A)
None
CA  B3001 (-2.9A)
 1.21A 4mdaA-2fcwB:
undetectable		 4mdaA-2fcwB:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 2fcw LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens) 		4 / 6 ASP B 112
ASP B 118
ALA B 120
ASP B 108
 CA  B3001 (-3.3A)
CA  B3001 (-3.3A)
None
CA  B3001 (-2.9A)
 1.18A 4mdbA-2fcwB:
undetectable		 4mdbA-2fcwB:
15.70