SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 2fd5 TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  73
LEU A  77
SER A  78
VAL A 179
 None
 0.73A 1dvxB-2fd5A:
undetectable		 1dvxB-2fd5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 2fd5 TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  20
GLY A  24
VAL A 113
ALA A 157
LEU A 156
 None
 1.18A 1gs4A-2fd5A:
undetectable		 1gs4A-2fd5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 2fd5 TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 145
LEU A 149
LEU A 135
LEU A  70
ALA A  87
 None
 1.11A 1h9zA-2fd5A:
undetectable		 1h9zA-2fd5A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 2fd5 TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  73
LEU A  77
SER A  78
VAL A 179
 None
 0.84A 1ictD-2fd5A:
undetectable		 1ictD-2fd5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2fd5 TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 146
LEU A 135
ALA A  88
ALA A  86
VAL A 132
 None
 1.28A 1kt4A-2fd5A:
undetectable		 1kt4A-2fd5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 2fd5 TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  73
LEU A  77
SER A  78
VAL A 179
 None
 0.75A 1tyrB-2fd5A:
undetectable		 1tyrB-2fd5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 2fd5 TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 9 GLU A  32
LEU A  13
LEU A  54
ALA A  25
ALA A  19
 None
 1.41A 2bxcB-2fd5A:
1.8		 2bxcB-2fd5A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2fd5 TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  63
VAL A 132
ARG A  67
 None
 0.90A 3b0wB-2fd5A:
undetectable		 3b0wB-2fd5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 2fd5 TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 6 GLN A  18
ASP A 101
GLU A  72
LEU A  62
 None
 1.27A 4ax8A-2fd5A:
undetectable		 4ax8A-2fd5A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 2fd5 TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  73
LEU A  77
SER A  78
VAL A 179
 None
 0.78A 5a6iA-2fd5A:
undetectable		 5a6iA-2fd5A:
22.70