SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fdr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2fdr CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 7 LEU A 118
VAL A 121
GLY A 122
ILE A  89
 None
 0.78A 1p2yA-2fdrA:
undetectable		 1p2yA-2fdrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2fdr CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		5 / 11 LEU A 200
ILE A 173
HIS A 191
GLY A  43
TYR A 193
 None
 1.24A 1zz1A-2fdrA:
undetectable		 1zz1A-2fdrA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 2fdr CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 5 LEU A  82
LEU A  78
LEU A  29
MET A  42
 None
 1.04A 2oaxF-2fdrA:
undetectable		 2oaxF-2fdrA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2fdr CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		3 / 3 ILE A   7
ILE A 184
LEU A 118
 None
 0.52A 2prgA-2fdrA:
undetectable		 2prgA-2fdrA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2fdr CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 7 ILE A   7
PHE A   9
ARG A  98
MET A 212
 None
 1.02A 3ag2N-2fdrA:
undetectable
3ag2W-2fdrA:
undetectable		 3ag2N-2fdrA:
19.18
3ag2W-2fdrA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 2fdr CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 7 TYR A  35
LEU A  71
LEU A  30
PHE A  46
 None
 1.02A 3nk2X-2fdrA:
undetectable		 3nk2X-2fdrA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2fdr CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 8 ASP A  10
GLY A 175
VAL A 163
ILE A   8
 MG  A1001 (-3.0A)
None
None
None
 0.76A 4ll3A-2fdrA:
undetectable		 4ll3A-2fdrA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2fdr CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		5 / 12 GLY A  91
ASP A  90
PHE A 186
GLY A  13
ASP A  17
 None
None
None
MG  A1001 ( 4.6A)
None
 1.12A 4pevB-2fdrA:
3.5		 4pevB-2fdrA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2fdr CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		3 / 3 SER A  18
ALA A  22
VAL A  25
 None
 0.62A 4x20C-2fdrA:
3.9		 4x20C-2fdrA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2fdr CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 7 ILE A   7
PHE A   9
ARG A  98
MET A 212
 None
 0.90A 5b1bN-2fdrA:
undetectable
5b1bW-2fdrA:
undetectable		 5b1bN-2fdrA:
19.18
5b1bW-2fdrA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2fdr CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		5 / 12 ILE A  89
VAL A  14
GLY A 188
ARG A 211
PRO A 216
 None
 1.09A 5ergB-2fdrA:
undetectable		 5ergB-2fdrA:
21.48