SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fe1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 10 LEU A  36
LEU A  38
ALA A  39
GLU A  42
LEU A  75
 None
 1.03A 1gwrA-2fe1A:
undetectable		 1gwrA-2fe1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 10 LEU A  38
ALA A  39
GLU A  42
HIS A  34
LEU A  75
 None
 1.13A 1gwrA-2fe1A:
undetectable		 1gwrA-2fe1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_B_ESTB600_1
(OESTROGEN RECEPTOR)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 9 LEU A  38
ALA A  39
GLU A  42
HIS A  34
LEU A  75
 None
 1.13A 1gwrB-2fe1A:
undetectable		 1gwrB-2fe1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		4 / 4 ALA A 101
VAL A  98
ALA A  91
HIS A  94
 None
 1.15A 1q23A-2fe1A:
undetectable		 1q23A-2fe1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		4 / 4 ALA A 101
VAL A  98
ALA A  91
HIS A  94
 None
 1.09A 1q23F-2fe1A:
undetectable		 1q23F-2fe1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		4 / 4 ALA A 101
VAL A  98
ALA A  91
HIS A  94
 None
 1.14A 1q23K-2fe1A:
undetectable		 1q23K-2fe1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 10 ALA A  26
ALA A  30
LEU A  33
LEU A 115
VAL A   5
 None
 1.13A 2bxeA-2fe1A:
undetectable		 2bxeA-2fe1A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 12 LEU A  36
LEU A  38
ALA A  39
GLU A  42
LEU A  75
 None
 1.08A 3q95B-2fe1A:
undetectable		 3q95B-2fe1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		6 / 12 LEU A  38
ALA A  39
GLU A  42
LEU A 114
HIS A  34
LEU A  75
 None
 1.25A 4j24D-2fe1A:
undetectable		 4j24D-2fe1A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 12 LEU A  36
LEU A  38
ALA A  39
GLU A  42
LEU A  75
 None
 1.10A 4pxmA-2fe1A:
undetectable		 4pxmA-2fe1A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 11 LEU A  38
ALA A  39
GLU A  42
HIS A  34
LEU A  75
 None
 1.14A 4pxmB-2fe1A:
undetectable		 4pxmB-2fe1A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		4 / 8 THR A  97
LEU A  38
VAL A   4
LEU A 114
 None
 1.02A 4r38B-2fe1A:
undetectable		 4r38B-2fe1A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 11 LEU A  36
ALA A  39
GLU A  42
HIS A  34
LEU A  75
 None
 1.22A 4zn7B-2fe1A:
undetectable		 4zn7B-2fe1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 10 LEU A  38
ALA A  39
GLU A  42
HIS A  34
LEU A  75
 None
 1.16A 5dx3A-2fe1A:
undetectable		 5dx3A-2fe1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 11 LEU A  38
ALA A  39
GLU A  42
HIS A  34
LEU A  75
 None
 1.10A 5dxgB-2fe1A:
undetectable		 5dxgB-2fe1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  10
VAL A  27
TYR A 103
ALA A  39
VAL A  77
 None
 1.17A 5n0oA-2fe1A:
undetectable		 5n0oA-2fe1A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  10
VAL A  27
TYR A 103
ALA A  39
VAL A  77
 None
 1.16A 5n0rA-2fe1A:
undetectable		 5n0rA-2fe1A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  10
VAL A  27
TYR A 103
ALA A  39
VAL A  77
 None
 1.15A 5n0sB-2fe1A:
undetectable		 5n0sB-2fe1A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  10
VAL A  27
TYR A 103
ALA A  39
VAL A  77
 None
 1.18A 5n0wA-2fe1A:
undetectable		 5n0wA-2fe1A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 12 LEU A  38
ALA A  39
GLU A  42
ILE A 110
LEU A 114
 None
 0.95A 5toaA-2fe1A:
undetectable		 5toaA-2fe1A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151
(Pyrobaculum
aerophilum) 		5 / 10 LEU A  38
ALA A  39
GLU A  42
HIS A  34
LEU A  75
 None
 1.13A 6cbzB-2fe1A:
undetectable		 6cbzB-2fe1A:
19.23