SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fe8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IIU_A_RTLA176_0 (PLASMA RETINOL-BINDING PROTEIN)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	5 / 11	LEU A 153 LEU A 151 ALA A 130 LEU A 173 ARG A 83	None None SO4 A 320 ( 4.1A) None None	1.25A	1iiuA-2fe8A: undetectable	1iiuA-2fe8A: 21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIA_A_ACTA294_0 (GLYCINE N-METHYLTRANSFERASE)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 6	TYR A 73 ASN A 14 TYR A 72 TYR A 84	None	1.26A	1kiaA-2fe8A: 0.0	1kiaA-2fe8A: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIA_B_ACTB1294_0 (GLYCINE N-METHYLTRANSFERASE)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 6	TYR A 73 ASN A 14 TYR A 72 TYR A 84	None	1.25A	1kiaB-2fe8A: 0.0	1kiaB-2fe8A: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIA_C_ACTC2294_0 (GLYCINE N-METHYLTRANSFERASE)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 7	TYR A 73 ASN A 14 TYR A 72 TYR A 84	None	1.26A	1kiaC-2fe8A: undetectable	1kiaC-2fe8A: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIA_D_ACTD3294_0 (GLYCINE N-METHYLTRANSFERASE)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 7	TYR A 73 ASN A 14 TYR A 72 TYR A 84	None	1.27A	1kiaD-2fe8A: undetectable	1kiaD-2fe8A: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KT5_A_RTLA176_0 (PLASMA RETINOL-BINDING PROTEIN)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	5 / 12	LEU A 153 LEU A 151 ALA A 130 LEU A 173 ARG A 83	None None SO4 A 320 ( 4.1A) None None	1.29A	1kt5A-2fe8A: undetectable	1kt5A-2fe8A: 20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_A_ACTA294_0 (GLYCINE N-METHYLTRANSFERASE)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 6	TYR A 73 ASN A 14 TYR A 72 TYR A 84	None	1.25A	1nbhA-2fe8A: 0.0	1nbhA-2fe8A: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_B_ACTB1294_0 (GLYCINE N-METHYLTRANSFERASE)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 7	TYR A 73 ASN A 14 TYR A 72 TYR A 84	None	1.27A	1nbhB-2fe8A: undetectable	1nbhB-2fe8A: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_C_ACTC2294_0 (GLYCINE N-METHYLTRANSFERASE)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 6	TYR A 73 ASN A 14 TYR A 72 TYR A 84	None	1.25A	1nbhC-2fe8A: 0.0	1nbhC-2fe8A: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_D_ACTD3294_0 (GLYCINE N-METHYLTRANSFERASE)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 7	TYR A 73 ASN A 14 TYR A 72 TYR A 84	None	1.26A	1nbhD-2fe8A: undetectable	1nbhD-2fe8A: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V54_J_CHDJ3060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE I CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 6	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.73A	1v54A-2fe8A: undetectable 1v54J-2fe8A: undetectable	1v54A-2fe8A: 19.88 1v54J-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DYR_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 1)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 6	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.68A	2dyrA-2fe8A: undetectable 2dyrJ-2fe8A: undetectable	2dyrA-2fe8A: 19.88 2dyrJ-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DYS_J_CHDJ101_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 1)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 6	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.65A	2dysA-2fe8A: undetectable 2dysJ-2fe8A: undetectable	2dysA-2fe8A: 19.88 2dysJ-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIJ_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 1)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 6	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.74A	2eijA-2fe8A: undetectable 2eijJ-2fe8A: undetectable	2eijA-2fe8A: 19.88 2eijJ-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2KQE_A_ADNA1002_1 (APRATAXIN AND PNK-LIKE FACTOR)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 5	TYR A 274 SER A 115 CYH A 112 TYR A 113	None	1.47A	2kqeA-2fe8A: 0.0	2kqeA-2fe8A: 17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WX2_B_TPFB1460_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 8	TYR A 72 TYR A 73 ALA A 154 ALA A 150	None	0.81A	2wx2B-2fe8A: undetectable	2wx2B-2fe8A: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_A_X2NA1480_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	5 / 12	TYR A 72 PHE A 80 TYR A 73 ALA A 154 ALA A 150	None	1.28A	2x2nA-2fe8A: undetectable	2x2nA-2fe8A: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_D_X2ND1479_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	5 / 12	TYR A 72 PHE A 80 TYR A 73 ALA A 154 ALA A 150	None	1.28A	2x2nD-2fe8A: undetectable	2x2nD-2fe8A: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZXW_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	5 / 6	LEU A 124 ARG A 167 MET A 170 THR A 171 LEU A 174	None	1.13A	2zxwA-2fe8A: 0.0 2zxwJ-2fe8A: undetectable	2zxwA-2fe8A: 19.88 2zxwJ-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABL_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 7	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.72A	3ablA-2fe8A: undetectable 3ablJ-2fe8A: undetectable	3ablA-2fe8A: 19.88 3ablJ-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABM_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 6	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.66A	3abmA-2fe8A: undetectable 3abmJ-2fe8A: undetectable	3abmA-2fe8A: 19.88 3abmJ-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG1_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 5	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.84A	3ag1J-2fe8A: undetectable	3ag1J-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG1_W_CHDW1059_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 6	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.75A	3ag1N-2fe8A: undetectable 3ag1W-2fe8A: undetectable	3ag1N-2fe8A: 19.88 3ag1W-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG2_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 5	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.65A	3ag2J-2fe8A: undetectable	3ag2J-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG4_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 5	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.74A	3ag4J-2fe8A: undetectable	3ag4J-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ASN_J_CHDJ60_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 6	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.73A	3asnA-2fe8A: undetectable 3asnJ-2fe8A: undetectable	3asnA-2fe8A: 19.88 3asnJ-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ASO_J_CHDJ60_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 6	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.71A	3asoA-2fe8A: undetectable 3asoJ-2fe8A: undetectable	3asoA-2fe8A: 19.88 3asoJ-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HGX_B_SALB104_1 (SALICYLATE BIOSYNTHESIS PROTEIN PCHB)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	5 / 9	VAL A 189 VAL A 185 TYR A 234 ILE A 315 GLN A 195	None	1.37A	3hgxB-2fe8A: undetectable	3hgxB-2fe8A: 16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3REM_A_SALA301_1 (SALICYLATE BIOSYNTHESIS PROTEIN PCHB)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	5 / 8	VAL A 189 VAL A 185 TYR A 234 ILE A 315 GLN A 195	None	1.36A	3remA-2fe8A: undetectable	3remA-2fe8A: 16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3REM_B_SALB301_1 (SALICYLATE BIOSYNTHESIS PROTEIN PCHB)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	5 / 8	VAL A 189 VAL A 185 TYR A 234 ILE A 315 GLN A 195	None	1.36A	3remB-2fe8A: undetectable	3remB-2fe8A: 16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DSG_A_0HKA1201_2 (MUSCARINIC ACETYLCHOLINE RECEPTOR M4,ENDOLYSIN,ENDOLYS IN,MUSCARINIC ACETYLCHOLINE RECEPTOR M4)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	3 / 3	ASN A 14 LEU A 65 PHE A 9	None	0.80A	5dsgA-2fe8A: undetectable	5dsgA-2fe8A: 23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IY5_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 7	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.78A	5iy5N-2fe8A: undetectable 5iy5W-2fe8A: undetectable	5iy5N-2fe8A: 19.88 5iy5W-2fe8A: 13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X19_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 5	ARG A 167 MET A 170 THR A 171 LEU A 174	None	1.17A	5x19J-2fe8A: undetectable	5x19J-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X1B_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 5	ARG A 167 MET A 170 THR A 171 LEU A 174	None	1.26A	5x1bJ-2fe8A: undetectable	5x1bJ-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X1B_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 5	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.63A	5x1bW-2fe8A: undetectable	5x1bW-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X1F_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 6	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.82A	5x1fA-2fe8A: undetectable 5x1fJ-2fe8A: undetectable	5x1fA-2fe8A: 19.88 5x1fJ-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X1F_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 5	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.59A	5x1fW-2fe8A: undetectable	5x1fW-2fe8A: 10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AY4_A_TPFA506_1 (CYP51, STEROL 14ALPHA-DEMETHYLASE)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	5 / 10	TYR A 72 PHE A 80 TYR A 73 ALA A 154 ALA A 150	None	1.47A	6ay4A-2fe8A: undetectable	6ay4A-2fe8A: 21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HD6_B_STIB601_1 (TYROSINE-PROTEIN KINASE ABL1)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 7	VAL A 117 ILE A 105 GLY A 39 ALA A 150	None	0.86A	6hd6B-2fe8A: undetectable	6hd6B-2fe8A: 14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_I_PCFI101_0 (CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL CYTOCHROME B-C1 COMPLEX SUBUNIT 9 CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	5 / 11	SER A 240 TYR A 214 GLY A 220 ALA A 231 VAL A 236	None	1.31A	6hu9A-2fe8A: undetectable 6hu9E-2fe8A: undetectable 6hu9I-2fe8A: undetectable	6hu9A-2fe8A: 20.18 6hu9E-2fe8A: 20.00 6hu9I-2fe8A: 11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_T_PCFT101_0 (CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL CYTOCHROME B-C1 COMPLEX SUBUNIT 9 CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	5 / 10	SER A 240 TYR A 214 GLY A 220 ALA A 231 VAL A 236	None	1.29A	6hu9L-2fe8A: undetectable 6hu9P-2fe8A: undetectable 6hu9T-2fe8A: undetectable	6hu9L-2fe8A: 20.18 6hu9P-2fe8A: 20.00 6hu9T-2fe8A: 11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NKN_J_CHDJ102_0 (CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2fe8	REPLICASE POLYPROTEIN 1AB (Severe acute respiratory syndrome-related coronavirus)	4 / 5	ARG A 167 MET A 170 THR A 171 LEU A 174	None	0.74A	6nknJ-2fe8A: undetectable	6nknJ-2fe8A: 10.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IIU_A_RTLA176_0","PLASMA RETINOL-BINDING PROTEIN","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",5,"LEU A 153;LEU A 151;ALA A 130;LEU A 173;ARG A  83","None;None;SO4 A 320 ( 4.1A);None;None","1.25A","1iiuA-2fe8A:undetectable","1iiuA-2fe8A:21.79"],["1KIA_A_ACTA294_0","GLYCINE N-METHYLTRANSFERASE","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"TYR A  73;ASN A  14;TYR A  72;TYR A  84","None","1.26A","1kiaA-2fe8A:0.0","1kiaA-2fe8A:24.14"],["1KIA_B_ACTB1294_0","GLYCINE N-METHYLTRANSFERASE","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"TYR A  73;ASN A  14;TYR A  72;TYR A  84","None","1.25A","1kiaB-2fe8A:0.0","1kiaB-2fe8A:24.14"],["1KIA_C_ACTC2294_0","GLYCINE N-METHYLTRANSFERASE","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"TYR A  73;ASN A  14;TYR A  72;TYR A  84","None","1.26A","1kiaC-2fe8A:undetectable","1kiaC-2fe8A:24.14"],["1KIA_D_ACTD3294_0","GLYCINE N-METHYLTRANSFERASE","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"TYR A  73;ASN A  14;TYR A  72;TYR A  84","None","1.27A","1kiaD-2fe8A:undetectable","1kiaD-2fe8A:24.14"],["1KT5_A_RTLA176_0","PLASMA RETINOL-BINDING PROTEIN","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",5,"LEU A 153;LEU A 151;ALA A 130;LEU A 173;ARG A  83","None;None;SO4 A 320 ( 4.1A);None;None","1.29A","1kt5A-2fe8A:undetectable","1kt5A-2fe8A:20.79"],["1NBH_A_ACTA294_0","GLYCINE N-METHYLTRANSFERASE","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"TYR A  73;ASN A  14;TYR A  72;TYR A  84","None","1.25A","1nbhA-2fe8A:0.0","1nbhA-2fe8A:24.14"],["1NBH_B_ACTB1294_0","GLYCINE N-METHYLTRANSFERASE","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"TYR A  73;ASN A  14;TYR A  72;TYR A  84","None","1.27A","1nbhB-2fe8A:undetectable","1nbhB-2fe8A:24.14"],["1NBH_C_ACTC2294_0","GLYCINE N-METHYLTRANSFERASE","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"TYR A  73;ASN A  14;TYR A  72;TYR A  84","None","1.25A","1nbhC-2fe8A:0.0","1nbhC-2fe8A:24.14"],["1NBH_D_ACTD3294_0","GLYCINE N-METHYLTRANSFERASE","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"TYR A  73;ASN A  14;TYR A  72;TYR A  84","None","1.26A","1nbhD-2fe8A:undetectable","1nbhD-2fe8A:24.14"],["1V54_J_CHDJ3060_0","CYTOCHROME C OXIDASE POLYPEPTIDE I;CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.73A","1v54A-2fe8A:undetectable;1v54J-2fe8A:undetectable","1v54A-2fe8A:19.88;1v54J-2fe8A:10.79"],["2DYR_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 1","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.68A","2dyrA-2fe8A:undetectable;2dyrJ-2fe8A:undetectable","2dyrA-2fe8A:19.88;2dyrJ-2fe8A:10.79"],["2DYS_J_CHDJ101_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 1","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.65A","2dysA-2fe8A:undetectable;2dysJ-2fe8A:undetectable","2dysA-2fe8A:19.88;2dysJ-2fe8A:10.79"],["2EIJ_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 1","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.74A","2eijA-2fe8A:undetectable;2eijJ-2fe8A:undetectable","2eijA-2fe8A:19.88;2eijJ-2fe8A:10.79"],["2KQE_A_ADNA1002_1","APRATAXIN AND PNK-LIKE FACTOR","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"TYR A 274;SER A 115;CYH A 112;TYR A 113","None","1.47A","2kqeA-2fe8A:0.0","2kqeA-2fe8A:17.39"],["2WX2_B_TPFB1460_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"TYR A  72;TYR A  73;ALA A 154;ALA A 150","None","0.81A","2wx2B-2fe8A:undetectable","2wx2B-2fe8A:21.12"],["2X2N_A_X2NA1480_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",5,"TYR A  72;PHE A  80;TYR A  73;ALA A 154;ALA A 150","None","1.28A","2x2nA-2fe8A:undetectable","2x2nA-2fe8A:19.71"],["2X2N_D_X2ND1479_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",5,"TYR A  72;PHE A  80;TYR A  73;ALA A 154;ALA A 150","None","1.28A","2x2nD-2fe8A:undetectable","2x2nD-2fe8A:19.71"],["2ZXW_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 1","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",5,"LEU A 124;ARG A 167;MET A 170;THR A 171;LEU A 174","None","1.13A","2zxwA-2fe8A:0.0;2zxwJ-2fe8A:undetectable","2zxwA-2fe8A:19.88;2zxwJ-2fe8A:10.79"],["3ABL_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 1","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.72A","3ablA-2fe8A:undetectable;3ablJ-2fe8A:undetectable","3ablA-2fe8A:19.88;3ablJ-2fe8A:10.79"],["3ABM_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 1","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.66A","3abmA-2fe8A:undetectable;3abmJ-2fe8A:undetectable","3abmA-2fe8A:19.88;3abmJ-2fe8A:10.79"],["3AG1_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.84A","3ag1J-2fe8A:undetectable","3ag1J-2fe8A:10.79"],["3AG1_W_CHDW1059_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 1","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.75A","3ag1N-2fe8A:undetectable;3ag1W-2fe8A:undetectable","3ag1N-2fe8A:19.88;3ag1W-2fe8A:10.79"],["3AG2_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.65A","3ag2J-2fe8A:undetectable","3ag2J-2fe8A:10.79"],["3AG4_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.74A","3ag4J-2fe8A:undetectable","3ag4J-2fe8A:10.79"],["3ASN_J_CHDJ60_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.73A","3asnA-2fe8A:undetectable;3asnJ-2fe8A:undetectable","3asnA-2fe8A:19.88;3asnJ-2fe8A:10.79"],["3ASO_J_CHDJ60_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.71A","3asoA-2fe8A:undetectable;3asoJ-2fe8A:undetectable","3asoA-2fe8A:19.88;3asoJ-2fe8A:10.79"],["3HGX_B_SALB104_1","SALICYLATE BIOSYNTHESIS PROTEIN PCHB","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",5,"VAL A 189;VAL A 185;TYR A 234;ILE A 315;GLN A 195","None","1.37A","3hgxB-2fe8A:undetectable","3hgxB-2fe8A:16.21"],["3REM_A_SALA301_1","SALICYLATE BIOSYNTHESIS PROTEIN PCHB","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",5,"VAL A 189;VAL A 185;TYR A 234;ILE A 315;GLN A 195","None","1.36A","3remA-2fe8A:undetectable","3remA-2fe8A:16.21"],["3REM_B_SALB301_1","SALICYLATE BIOSYNTHESIS PROTEIN PCHB","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",5,"VAL A 189;VAL A 185;TYR A 234;ILE A 315;GLN A 195","None","1.36A","3remB-2fe8A:undetectable","3remB-2fe8A:16.21"],["5DSG_A_0HKA1201_2","MUSCARINIC ACETYLCHOLINE RECEPTOR M4,ENDOLYSIN,ENDOLYSIN,MUSCARINIC ACETYLCHOLINE RECEPTOR M4","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",3,"ASN A  14;LEU A  65;PHE A   9","None","0.80A","5dsgA-2fe8A:undetectable","5dsgA-2fe8A:23.63"],["5IY5_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.78A","5iy5N-2fe8A:undetectable;5iy5W-2fe8A:undetectable","5iy5N-2fe8A:19.88;5iy5W-2fe8A:13.57"],["5X19_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","1.17A","5x19J-2fe8A:undetectable","5x19J-2fe8A:10.79"],["5X1B_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","1.26A","5x1bJ-2fe8A:undetectable","5x1bJ-2fe8A:10.79"],["5X1B_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.63A","5x1bW-2fe8A:undetectable","5x1bW-2fe8A:10.79"],["5X1F_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.82A","5x1fA-2fe8A:undetectable;5x1fJ-2fe8A:undetectable","5x1fA-2fe8A:19.88;5x1fJ-2fe8A:10.79"],["5X1F_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.59A","5x1fW-2fe8A:undetectable","5x1fW-2fe8A:10.79"],["6AY4_A_TPFA506_1","CYP51, STEROL 14ALPHA-DEMETHYLASE","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",5,"TYR A  72;PHE A  80;TYR A  73;ALA A 154;ALA A 150","None","1.47A","6ay4A-2fe8A:undetectable","6ay4A-2fe8A:21.56"],["6HD6_B_STIB601_1","TYROSINE-PROTEIN KINASE ABL1","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"VAL A 117;ILE A 105;GLY A  39;ALA A 150","None","0.86A","6hd6B-2fe8A:undetectable","6hd6B-2fe8A:14.01"],["6HU9_I_PCFI101_0","CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL;CYTOCHROME B-C1 COMPLEX SUBUNIT 9;CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",5,"SER A 240;TYR A 214;GLY A 220;ALA A 231;VAL A 236","None","1.31A","6hu9A-2fe8A:undetectable;6hu9E-2fe8A:undetectable;6hu9I-2fe8A:undetectable","6hu9A-2fe8A:20.18;6hu9E-2fe8A:20.00;6hu9I-2fe8A:11.49"],["6HU9_T_PCFT101_0","CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL;CYTOCHROME B-C1 COMPLEX SUBUNIT 9;CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",5,"SER A 240;TYR A 214;GLY A 220;ALA A 231;VAL A 236","None","1.29A","6hu9L-2fe8A:undetectable;6hu9P-2fe8A:undetectable;6hu9T-2fe8A:undetectable","6hu9L-2fe8A:20.18;6hu9P-2fe8A:20.00;6hu9T-2fe8A:11.49"],["6NKN_J_CHDJ102_0","CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2fe8","REPLICASE POLYPROTEIN 1AB","Severe acute respiratory syndrome-related coronavirus",4,"ARG A 167;MET A 170;THR A 171;LEU A 174","None","0.74A","6nknJ-2fe8A:undetectable","6nknJ-2fe8A:10.79"]]