SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fea'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		4 / 5 PHE A 104
ASN A  21
ILE A  22
ASP A  13
 None
EDO  A1305 (-3.4A)
EDO  A1306 ( 3.8A)
None
 1.11A 1yc2D-2feaA:
5.4		 1yc2D-2feaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		4 / 8 ILE A  23
ILE A  22
ILE A  67
ALA A 124
 EDO  A1306 ( 4.9A)
EDO  A1306 ( 3.8A)
None
None
 0.69A 2nniA-2feaA:
undetectable		 2nniA-2feaA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		5 / 11 ILE A 113
ALA A  86
PHE A 207
PHE A  81
VAL A 114
 None
 0.96A 2w3aA-2feaA:
undetectable		 2w3aA-2feaA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		5 / 9 ILE A  22
MET A 102
VAL A  52
ILE A 131
ILE A 133
 EDO  A1306 ( 3.8A)
None
None
None
None
 1.19A 3p4wB-2feaA:
undetectable		 3p4wB-2feaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		5 / 10 ILE A  22
MET A 102
VAL A  52
ILE A 131
ILE A 133
 EDO  A1306 ( 3.8A)
None
None
None
None
 1.20A 3p4wD-2feaA:
undetectable		 3p4wD-2feaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		5 / 10 ILE A  22
MET A 102
VAL A  52
ILE A 131
ILE A 133
 EDO  A1306 ( 3.8A)
None
None
None
None
 1.20A 3p4wE-2feaA:
undetectable		 3p4wE-2feaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		5 / 10 ILE A  77
ALA A  75
SER A  99
ILE A 119
ILE A  16
 None
EDO  A1305 (-3.6A)
None
None
None
 1.22A 3qgtA-2feaA:
undetectable		 3qgtA-2feaA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		5 / 12 PHE A  84
PHE A  87
ILE A   8
VAL A 217
VAL A 220
 None
 1.45A 4yfbC-2feaA:
undetectable		 4yfbC-2feaA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		5 / 12 PHE A  84
PHE A  87
ILE A   8
VAL A 217
VAL A 220
 None
 1.45A 4yfbF-2feaA:
undetectable		 4yfbF-2feaA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		5 / 12 PHE A  84
PHE A  87
ILE A   8
VAL A 217
VAL A 220
 None
 1.43A 4yfbI-2feaA:
undetectable		 4yfbI-2feaA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		5 / 12 PHE A  84
PHE A  87
ILE A   8
VAL A 217
VAL A 220
 None
 1.44A 4yfbL-2feaA:
undetectable		 4yfbL-2feaA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		4 / 4 LEU A 109
ARG A  82
ILE A  77
ILE A 113
 None
 1.33A 5dzk2-2feaA:
undetectable
5dzkM-2feaA:
undetectable
5dzkN-2feaA:
undetectable		 5dzk2-2feaA:
1.80
5dzkM-2feaA:
21.51
5dzkN-2feaA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		4 / 4 ILE A  77
ILE A 113
ARG A  82
LEU A 109
 None
 1.21A 5dzkh-2feaA:
undetectable
5dzkn-2feaA:
undetectable
5dzkv-2feaA:
undetectable		 5dzkh-2feaA:
21.51
5dzkn-2feaA:
21.51
5dzkv-2feaA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		3 / 3 GLY A 148
CYH A 139
CYH A 150
 None
ZN  A1302 (-2.2A)
ZN  A1302 (-2.3A)
 0.85A 5inzB-2feaA:
undetectable		 5inzB-2feaA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		4 / 7 ARG A  78
GLU A 209
ARG A 187
PRO A 203
 None
 1.46A 6a4iB-2feaA:
undetectable		 6a4iB-2feaA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE
(Bacillus
subtilis) 		5 / 12 ILE A  67
SER A  61
PHE A 104
LEU A  72
ASP A 103
 None
 1.49A 6dwnB-2feaA:
undetectable		 6dwnB-2feaA:
20.71