SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 157
GLY A 156
ALA A 262
LEU A 266
 None
 0.63A 1e7bB-2fefA:
2.4		 1e7bB-2fefA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		5 / 11 SER A 277
LEU A 263
LEU A 150
PRO A 203
THR A 198
 None
 1.49A 1mxfC-2fefA:
undetectable		 1mxfC-2fefA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 173
GLN A 174
PHE A 175
LEU A 153
 None
 1.02A 1v55P-2fefA:
2.3
1v55W-2fefA:
undetectable		 1v55P-2fefA:
23.55
1v55W-2fefA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 173
GLN A 174
PHE A 175
LEU A 153
 None
 1.02A 2dysC-2fefA:
2.2
2dysJ-2fefA:
undetectable		 2dysC-2fefA:
23.55
2dysJ-2fefA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 173
GLN A 174
PHE A 175
LEU A 153
 None
 1.03A 2eijP-2fefA:
2.3
2eijW-2fefA:
undetectable		 2eijP-2fefA:
23.55
2eijW-2fefA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 246
GLY A 249
PRO A 250
 None
 0.73A 2hreD-2fefA:
undetectable		 2hreD-2fefA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 148
ALA A  80
ALA A 108
GLY A  77
TYR A 146
 None
 1.29A 2igtC-2fefA:
undetectable		 2igtC-2fefA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  16
PRO A  17
ARG A  59
 None
 0.64A 2qd4B-2fefA:
undetectable		 2qd4B-2fefA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  16
PRO A  17
ARG A  59
 None
 0.65A 2qd5A-2fefA:
undetectable		 2qd5A-2fefA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 6 ASP A  92
ILE A  91
LEU A 281
TYR A 230
 None
 1.04A 2ya7A-2fefA:
undetectable		 2ya7A-2fefA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 6 ASP A  92
ILE A  91
LEU A 281
TYR A 230
 None
 1.02A 2ya7B-2fefA:
undetectable		 2ya7B-2fefA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 6 ASP A  92
ILE A  91
LEU A 281
TYR A 230
 None
 1.04A 2ya7D-2fefA:
undetectable		 2ya7D-2fefA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 7 ASN A  10
ALA A  80
ALA A  79
ALA A  83
 None
 0.81A 3a2qA-2fefA:
undetectable		 3a2qA-2fefA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 173
GLN A 174
PHE A 175
LEU A 153
 None
 1.01A 3ag1C-2fefA:
3.2
3ag1J-2fefA:
undetectable		 3ag1C-2fefA:
23.55
3ag1J-2fefA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 8 TYR A  58
ALA A  80
ALA A  83
LEU A  16
 None
 0.92A 3l4dA-2fefA:
undetectable		 3l4dA-2fefA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		3 / 3 THR A 143
ASP A 176
GLU A 197
 None
 0.78A 3qowA-2fefA:
undetectable		 3qowA-2fefA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 139
PHE A 148
PRO A 147
ALA A 252
 None
 1.36A 3vm4A-2fefA:
undetectable		 3vm4A-2fefA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 246
LEU A 181
ALA A 154
GLU A 259
TYR A 230
 None
 1.39A 4cpzB-2fefA:
undetectable		 4cpzB-2fefA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 246
LEU A 181
ALA A 154
GLU A 259
TYR A 230
 None
 1.41A 4cpzE-2fefA:
undetectable		 4cpzE-2fefA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 149
PRO A 147
LEU A 181
LEU A 173
 None
 0.98A 4jjkA-2fefA:
undetectable		 4jjkA-2fefA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 263
LEU A 153
GLY A 185
ALA A 186
LEU A 191
 None
 1.08A 4rrxA-2fefA:
undetectable		 4rrxA-2fefA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 263
LEU A 153
GLY A 185
ALA A 186
LEU A 191
 None
 1.08A 4rrxB-2fefA:
undetectable		 4rrxB-2fefA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		3 / 3 THR A 143
ASP A 176
GLU A 197
 None
 0.75A 5fa8A-2fefA:
undetectable		 5fa8A-2fefA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 263
LEU A 207
ARG A 231
 None
 0.62A 5hnzB-2fefA:
undetectable		 5hnzB-2fefA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  49
PHE A  52
LEU A 117
TRP A  76
LEU A   8
 None
 1.36A 5ieoA-2fefA:
undetectable		 5ieoA-2fefA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 173
GLN A 174
PHE A 175
LEU A 153
 None
 0.94A 5iy5C-2fefA:
2.3
5iy5J-2fefA:
undetectable		 5iy5C-2fefA:
23.38
5iy5J-2fefA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		5 / 8 ALA A 257
LEU A 180
LEU A 184
LEU A 222
LEU A 207
 None
 1.20A 5jqbA-2fefA:
undetectable
5jqbB-2fefA:
undetectable		 5jqbA-2fefA:
23.82
5jqbB-2fefA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 173
GLN A 174
PHE A 175
LEU A 153
 None
 0.89A 5z84C-2fefA:
2.3
5z84J-2fefA:
undetectable		 5z84C-2fefA:
23.55
5z84J-2fefA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 2fef HYPOTHETICAL PROTEIN
PA2201
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 100
GLY A  94
ARG A  30
ARG A  27
 None
 1.36A 6gtqB-2fefA:
undetectable
6gtqD-2fefA:
undetectable		 6gtqB-2fefA:
21.33
6gtqD-2fefA:
11.24