SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fej'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 2fej CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens) 		5 / 12 PHE A 270
ILE A 195
PRO A 278
VAL A 122
VAL A 274
 None
 1.35A 1hrkB-2fejA:
undetectable		 1hrkB-2fejA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 2fej CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens) 		3 / 3 CYH A 238
CYH A 176
HIS A 179
 ZN  A   1 (-2.4A)
ZN  A   1 (-2.3A)
ZN  A   1 (-3.3A)
 0.88A 2iwkA-2fejA:
undetectable		 2iwkA-2fejA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2fej CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens) 		5 / 12 PHE A 270
ILE A 195
PRO A 278
VAL A 122
VAL A 274
 None
 1.31A 2pnjB-2fejA:
undetectable		 2pnjB-2fejA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2fej CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens) 		4 / 7 ILE A 251
ARG A 158
ILE A 255
PHE A 270
 None
 1.06A 2q6hA-2fejA:
undetectable		 2q6hA-2fejA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2fej CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens) 		4 / 7 ILE A 255
LEU A 111
PHE A 270
TYR A 236
 None
 1.17A 2zxwN-2fejA:
undetectable
2zxwW-2fejA:
undetectable		 2zxwN-2fejA:
15.09
2zxwW-2fejA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2fej CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens) 		5 / 8 ILE A 255
LEU A 111
PHE A 270
TYR A 236
THR A 140
 None
 1.47A 3abmN-2fejA:
undetectable
3abmW-2fejA:
undetectable		 3abmN-2fejA:
15.09
3abmW-2fejA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2fej CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens) 		5 / 7 ILE A 255
LEU A 111
PHE A 270
TYR A 236
THR A 140
 None
 1.46A 3ag4N-2fejA:
undetectable
3ag4W-2fejA:
undetectable		 3ag4N-2fejA:
15.09
3ag4W-2fejA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 2fej CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens) 		5 / 11 PHE A 270
ILE A 195
PRO A 278
VAL A 122
VAL A 274
 None
 1.35A 3aqiA-2fejA:
undetectable		 3aqiA-2fejA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2fej CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens) 		5 / 11 ALA A 161
SER A 215
HIS A 214
GLN A 192
ARG A 213
 None
 1.44A 3kp5A-2fejA:
undetectable		 3kp5A-2fejA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2fej CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens) 		5 / 12 PHE A 270
ILE A 195
PRO A 278
VAL A 122
VAL A 274
 None
 1.39A 3w1wB-2fejA:
undetectable		 3w1wB-2fejA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2fej CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens) 		5 / 12 ALA A 161
SER A 215
HIS A 214
GLN A 192
ARG A 213
 None
 1.26A 4ejwA-2fejA:
undetectable		 4ejwA-2fejA:
18.05