SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 2fek LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE WZB
(Escherichia
coli) 		4 / 6 ALA A  19
SER A  69
LEU A  23
TRP A 138
 None
 1.13A 1gahA-2fekA:
undetectable		 1gahA-2fekA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2fek LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE WZB
(Escherichia
coli) 		5 / 12 LEU A 131
ALA A 135
LEU A  23
VAL A   7
LEU A  60
 None
 0.98A 1s9pA-2fekA:
undetectable		 1s9pA-2fekA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2fek LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE WZB
(Escherichia
coli) 		5 / 12 LEU A 131
ALA A 135
LEU A  23
VAL A   7
LEU A  60
 None
 0.99A 1s9pD-2fekA:
undetectable		 1s9pD-2fekA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 2fek LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE WZB
(Escherichia
coli) 		5 / 10 GLU A 132
LEU A  23
LEU A  22
LEU A  80
MET A 102
 None
 1.38A 3erdB-2fekA:
undetectable		 3erdB-2fekA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2fek LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE WZB
(Escherichia
coli) 		3 / 5 GLY A  44
GLY A  62
GLU A  61
 None
 0.46A 4z2eA-2fekA:
undetectable
4z2eD-2fekA:
3.0		 4z2eA-2fekA:
16.45
4z2eD-2fekA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 2fek LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE WZB
(Escherichia
coli) 		4 / 6 ILE A   5
GLY A  36
ASN A  12
ILE A  79
 None
 0.92A 5j4nB-2fekA:
undetectable		 5j4nB-2fekA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2fek LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE WZB
(Escherichia
coli) 		3 / 3 ASP A 115
PHE A 124
ARG A 118
 None
 1.14A 5yw0A-2fekA:
undetectable		 5yw0A-2fekA:
21.36