SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fel'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IHI_A_IU5A326_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		5 / 10 VAL A 111
VAL A  83
ILE A  87
GLU A  44
LEU A  62
 None
 1.23A 1ihiA-2felA:
undetectable		 1ihiA-2felA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		4 / 7 PHE A 194
GLU A  37
LEU A  40
THR A 107
 None
 1.13A 1rmtB-2felA:
undetectable		 1rmtB-2felA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		5 / 12 PHE A  24
GLY A 332
VAL A 244
LEU A 335
LEU A 120
 None
 1.28A 1ya4B-2felA:
undetectable		 1ya4B-2felA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		5 / 11 VAL A  94
ALA A  93
SER A  63
LEU A  62
VAL A  59
 None
 1.36A 2c12B-2felA:
1.3		 2c12B-2felA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		4 / 8 LEU A 335
ILE A 127
LEU A 131
LEU A 248
 None
 0.62A 2xfhA-2felA:
undetectable		 2xfhA-2felA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		4 / 5 ARG A 231
ASP A 113
ILE A 112
GLU A 320
 None
 1.17A 2xrzA-2felA:
undetectable
2xrzB-2felA:
undetectable		 2xrzA-2felA:
22.04
2xrzB-2felA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		3 / 3 GLU A 339
HIS A 133
THR A 137
 None
 0.86A 3hkuA-2felA:
undetectable		 3hkuA-2felA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		5 / 12 MET A 117
LEU A 120
ALA A 124
LEU A 182
ILE A 234
 None
 1.08A 3olsB-2felA:
2.5		 3olsB-2felA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		3 / 3 ARG A 181
LEU A 240
THR A 245
 None
 0.87A 3oxcA-2felA:
undetectable		 3oxcA-2felA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		3 / 3 THR A 107
SER A 108
ARG A 312
 None
CL  A1507 ( 4.5A)
None
 0.73A 3phnA-2felA:
undetectable		 3phnA-2felA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		4 / 8 HIS A 103
VAL A  83
VAL A  81
ASP A 110
 None
 1.12A 3uy4A-2felA:
undetectable		 3uy4A-2felA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 341
ALA A 338
LEU A 131
LEU A 134
ILE A 135
 None
 0.90A 4dm8B-2felA:
undetectable		 4dm8B-2felA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		5 / 12 ALA A 186
LEU A 241
MET A 117
LEU A 116
PHE A  24
 None
 1.19A 4kykA-2felA:
undetectable
4kykB-2felA:
undetectable		 4kykA-2felA:
20.17
4kykB-2felA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		4 / 6 LEU A 336
LEU A 291
ILE A  21
PHE A   6
 None
 1.05A 4y4dA-2felA:
undetectable		 4y4dA-2felA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		5 / 12 GLY A 349
PHE A 251
LEU A 138
ARG A 144
ASP A 145
 None
 1.00A 5nknA-2felA:
undetectable		 5nknA-2felA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		5 / 12 ILE A  49
PHE A  36
ALA A 216
LEU A 215
ALA A  39
 None
 1.01A 5oy02-2felA:
undetectable		 5oy02-2felA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		4 / 8 LEU A 131
ILE A 172
LEU A 341
ALA A 338
 None
 0.79A 5y7pC-2felA:
undetectable		 5y7pC-2felA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		4 / 6 GLU A  46
ARG A 218
GLU A  44
ALA A  45
 None
 1.16A 6an0A-2felA:
undetectable		 6an0A-2felA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME
(Agrobacterium
tumefaciens) 		5 / 12 GLY A 314
ARG A 231
THR A 107
GLY A 196
GLY A 195
 None
 1.21A 6brdB-2felA:
undetectable		 6brdB-2felA:
12.87