SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2fem CYTIDYLATE KINASE
(Escherichia
coli) 		4 / 7 GLY A  15
SER A 150
ARG A 157
GLU A 152
 None
 1.08A 2c8aD-2femA:
undetectable		 2c8aD-2femA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2fem CYTIDYLATE KINASE
(Escherichia
coli) 		4 / 5 SER A  73
LEU A  21
GLY A  19
GLU A  27
 None
 1.23A 3aiaA-2femA:
undetectable
3aiaB-2femA:
undetectable		 3aiaA-2femA:
22.57
3aiaB-2femA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 2fem CYTIDYLATE KINASE
(Escherichia
coli) 		4 / 4 ILE A  10
ARG A 221
ILE A   8
THR A  20
 None
 1.14A 3ia4C-2femA:
undetectable		 3ia4C-2femA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2fem CYTIDYLATE KINASE
(Escherichia
coli) 		3 / 3 HIS A 156
SER A 150
GLU A 153
 None
 0.81A 3s8pA-2femA:
undetectable		 3s8pA-2femA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2fem CYTIDYLATE KINASE
(Escherichia
coli) 		4 / 7 PRO A  13
GLY A  15
ALA A  16
ASP A 203
 None
 0.66A 3ur0B-2femA:
undetectable		 3ur0B-2femA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 2fem CYTIDYLATE KINASE
(Escherichia
coli) 		4 / 5 GLY A  12
ARG A 154
ASP A  11
GLN A 117
 None
 1.45A 5ubbA-2femA:
undetectable		 5ubbA-2femA:
21.60