SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fep'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		5 / 12 GLY A 299
SER A  77
ALA A 146
ASP A 297
ILE A 298
 None
 1.10A 1nt2A-2fepA:
3.4		 1nt2A-2fepA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		5 / 12 THR A 278
ASP A 276
GLY A 274
ILE A 255
ALA A 258
 SO4  A4396 (-2.9A)
SO4  A4396 (-3.5A)
None
None
None
 1.35A 1oltA-2fepA:
undetectable		 1oltA-2fepA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		5 / 10 GLY A 120
VAL A 118
LEU A 114
LEU A 110
SER A 139
 None
 1.27A 1pbcA-2fepA:
undetectable		 1pbcA-2fepA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		3 / 3 GLU A 190
GLU A 151
LEU A 145
 None
 0.73A 1v8bB-2fepA:
5.9		 1v8bB-2fepA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		4 / 8 PHE A 123
GLU A 106
GLN A 101
TYR A  76
 None
None
None
SO4  A4397 (-4.5A)
 1.33A 2aoxA-2fepA:
2.1		 2aoxA-2fepA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		3 / 3 LEU A 210
PRO A 211
LEU A 205
 None
 0.51A 3hcrA-2fepA:
4.2		 3hcrA-2fepA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		4 / 5 LEU A 280
THR A 278
GLU A 250
HIS A 257
 SO4  A4396 ( 4.7A)
SO4  A4396 (-2.9A)
None
None
 1.25A 3n58C-2fepA:
undetectable		 3n58C-2fepA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		5 / 12 TYR A 222
ASP A 276
GLN A 293
ILE A 298
GLY A 126
 SO4  A4397 (-4.2A)
SO4  A4396 (-3.5A)
SO4  A4397 ( 4.9A)
None
None
 1.43A 4iilA-2fepA:
18.8		 4iilA-2fepA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		4 / 7 GLY A 220
ASP A 221
GLY A 227
GLU A 229
 None
 0.85A 4koeA-2fepA:
undetectable
4koeB-2fepA:
undetectable
4koeD-2fepA:
3.4		 4koeA-2fepA:
21.10
4koeB-2fepA:
21.10
4koeD-2fepA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		3 / 3 TYR A 222
GLY A 186
PRO A 187
 SO4  A4397 (-4.2A)
None
None
 0.69A 4qwpA-2fepA:
undetectable		 4qwpA-2fepA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		5 / 8 ALA A 189
GLU A 219
ALA A 218
PHE A 183
LEU A 198
 None
 1.45A 4v1fA-2fepA:
undetectable
4v1fB-2fepA:
undetectable		 4v1fA-2fepA:
16.94
4v1fB-2fepA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		5 / 12 GLY A 126
GLY A 125
ILE A 192
GLN A 152
PHE A 136
 None
 1.23A 4zvmA-2fepA:
5.3
4zvmB-2fepA:
5.8		 4zvmA-2fepA:
25.08
4zvmB-2fepA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		5 / 11 GLN A 152
PHE A 136
GLY A 126
GLY A 125
ILE A 192
 None
 1.35A 4zvmA-2fepA:
5.3
4zvmB-2fepA:
5.8		 4zvmA-2fepA:
25.08
4zvmB-2fepA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		4 / 7 TYR A 222
TYR A  76
GLY A 125
SER A 148
 SO4  A4397 (-4.2A)
SO4  A4397 (-4.5A)
None
None
 1.05A 5bphB-2fepA:
6.3		 5bphB-2fepA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		5 / 12 VAL A 184
ALA A 252
THR A 278
PHE A  75
TYR A  76
 None
None
SO4  A4396 (-2.9A)
SO4  A4397 ( 3.2A)
SO4  A4397 (-4.5A)
 1.25A 5igiA-2fepA:
undetectable		 5igiA-2fepA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN8_D_AZMD701_1
(CARBONIC ANHYDRASE 4)		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		5 / 10 GLN A 152
GLU A 106
HIS A 132
VAL A 133
LEU A 145
 None
 1.42A 5jn8D-2fepA:
undetectable		 5jn8D-2fepA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 2fep CATABOLITE CONTROL
PROTEIN A
(Bacillus
subtilis) 		5 / 12 GLY A 125
GLU A 104
GLU A 106
LEU A 107
LEU A 110
 None
 0.96A 5nwvA-2fepA:
undetectable		 5nwvA-2fepA:
10.53