SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2few'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2few PTS SYSTEM
MANNITOL-SPECIFIC
EIICBA COMPONENT
(Escherichia
coli) 		5 / 12 GLY A  78
PHE A   5
VAL A  80
ALA A 105
TYR A  42
 None
 1.36A 2avdA-2fewA:
undetectable		 2avdA-2fewA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2few PTS SYSTEM
MANNITOL-SPECIFIC
EIICBA COMPONENT
(Escherichia
coli) 		5 / 12 GLY A  78
PHE A   5
VAL A  80
ALA A 105
TYR A  42
 None
 1.30A 2avdB-2fewA:
undetectable		 2avdB-2fewA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2few PTS SYSTEM
MANNITOL-SPECIFIC
EIICBA COMPONENT
(Escherichia
coli) 		5 / 8 GLY A 103
GLY A  78
THR A  77
ALA A 106
ALA A 105
 None
 1.30A 2ej3C-2fewA:
undetectable		 2ej3C-2fewA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2few PTS SYSTEM
MANNITOL-SPECIFIC
EIICBA COMPONENT
(Escherichia
coli) 		5 / 12 VAL A 101
ILE A 102
ILE A  61
VAL A  63
PRO A  64
 None
 1.04A 3kpdC-2fewA:
undetectable		 3kpdC-2fewA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2few PTS SYSTEM
MANNITOL-SPECIFIC
EIICBA COMPONENT
(Escherichia
coli) 		5 / 12 VAL A  79
ALA A 106
THR A  55
LEU A  57
THR A  77
 None
 1.15A 3qfxA-2fewA:
undetectable		 3qfxA-2fewA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2few PTS SYSTEM
MANNITOL-SPECIFIC
EIICBA COMPONENT
(Escherichia
coli) 		5 / 12 VAL A  79
ALA A 106
THR A  55
LEU A  57
THR A  77
 None
 1.12A 3qfxB-2fewA:
undetectable		 3qfxB-2fewA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2few PTS SYSTEM
MANNITOL-SPECIFIC
EIICBA COMPONENT
(Escherichia
coli) 		5 / 11 LEU A 122
LEU A 131
GLU A 142
ALA A 145
LEU A 144
 None
 0.85A 4wg0B-2fewA:
undetectable
4wg0C-2fewA:
undetectable
4wg0D-2fewA:
undetectable		 4wg0B-2fewA:
5.41
4wg0C-2fewA:
5.41
4wg0D-2fewA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2few PTS SYSTEM
MANNITOL-SPECIFIC
EIICBA COMPONENT
(Escherichia
coli) 		5 / 11 LEU A 122
LEU A 131
GLU A 142
ALA A 145
LEU A 144
 None
 0.85A 4wg0D-2fewA:
undetectable
4wg0E-2fewA:
undetectable
4wg0F-2fewA:
undetectable		 4wg0D-2fewA:
5.41
4wg0E-2fewA:
5.41
4wg0F-2fewA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2few PTS SYSTEM
MANNITOL-SPECIFIC
EIICBA COMPONENT
(Escherichia
coli) 		5 / 11 LEU A 122
LEU A 131
GLU A 142
ALA A 145
LEU A 144
 None
 0.89A 4wg0F-2fewA:
undetectable
4wg0G-2fewA:
undetectable
4wg0H-2fewA:
undetectable		 4wg0F-2fewA:
5.41
4wg0G-2fewA:
5.41
4wg0H-2fewA:
5.41