SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 8 LEU A  67
GLY A 111
PHE A  90
VAL A  97
 None
 0.74A 1d4sB-2fexA:
undetectable		 1d4sB-2fexA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 5 SER A 146
LEU A 166
GLY A 170
GLU A 164
 None
 1.22A 3aiaA-2fexA:
undetectable
3aiaB-2fexA:
2.8		 3aiaA-2fexA:
22.27
3aiaB-2fexA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 6 ARG A   3
ILE A   4
VAL A  33
HIS A  34
 None
 1.28A 3deuA-2fexA:
undetectable		 3deuA-2fexA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 6 TYR A 138
GLY A 120
VAL A 145
THR A 152
 None
 0.89A 3tj7A-2fexA:
undetectable
3tj7B-2fexA:
undetectable		 3tj7A-2fexA:
21.24
3tj7B-2fexA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 6 TYR A 138
GLY A 120
VAL A 145
THR A 152
 None
 0.88A 3tj7C-2fexA:
undetectable
3tj7D-2fexA:
undetectable		 3tj7C-2fexA:
21.24
3tj7D-2fexA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 6 VAL A 145
THR A 152
TYR A 138
GLY A 120
 None
 0.90A 3tj7C-2fexA:
undetectable
3tj7D-2fexA:
undetectable		 3tj7C-2fexA:
21.24
3tj7D-2fexA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		3 / 3 PHE A 172
VAL A  68
ILE A   4
 None
 0.63A 4emaA-2fexA:
undetectable		 4emaA-2fexA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 7 ALA A   7
PRO A  37
LEU A  59
LEU A  67
 None
 0.86A 4iomA-2fexA:
4.3		 4iomA-2fexA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 8 ALA A   7
PRO A  37
LEU A  59
LEU A  67
 None
 0.84A 4jjkA-2fexA:
undetectable		 4jjkA-2fexA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 6 ASP A  14
GLY A  72
PRO A  37
THR A  36
 None
 1.08A 4l1aB-2fexA:
undetectable		 4l1aB-2fexA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 7 ALA A   9
THR A  36
ALA A  35
MET A  45
 None
 0.85A 4qw0K-2fexA:
undetectable		 4qw0K-2fexA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 7 ALA A   9
THR A  36
ALA A  35
MET A  45
 None
 0.85A 4qw0Y-2fexA:
undetectable		 4qw0Y-2fexA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		4 / 7 GLY A  71
GLY A 155
SER A 156
GLU A  76
 None
 0.85A 5izfA-2fexA:
undetectable		 5izfA-2fexA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		5 / 10 ILE A 165
ILE A  32
ALA A   5
ILE A   6
ILE A  64
 None
 1.01A 5mvmD-2fexA:
undetectable
5mvmE-2fexA:
undetectable		 5mvmD-2fexA:
17.02
5mvmE-2fexA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		5 / 12 ALA A  58
PHE A 161
ALA A 153
ALA A 104
THR A  36
 None
 1.26A 5tl8A-2fexA:
undetectable		 5tl8A-2fexA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		5 / 12 LEU A  83
PHE A  12
GLY A  71
LEU A  20
LEU A  48
 None
 1.04A 5y2tA-2fexA:
undetectable		 5y2tA-2fexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 2fex CONSERVED
HYPOTHETICAL PROTEIN
(Agrobacterium
fabrum) 		6 / 10 GLU A  16
GLY A  71
GLY A  72
ILE A 100
ALA A 102
GLY A 155
 None
 0.31A 6e5zA-2fexA:
21.9		 6e5zA-2fexA:
25.89