SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 292
TYR A 301
ILE A 310
ILE A 371
 None
 0.80A 2bu8A-2fezA:
1.8		 2bu8A-2fezA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 370
ASP A 343
ASN A 348
 None
 0.87A 2zzmA-2fezA:
undetectable		 2zzmA-2fezA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 333
ILE A 357
ILE A 371
ILE A 332
THR A 164
 None
 1.16A 3hbbD-2fezA:
undetectable		 3hbbD-2fezA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 318
ASN A 342
ALA A 330
LEU A 320
VAL A 350
 None
 1.24A 3o01A-2fezA:
undetectable
3o01B-2fezA:
0.0		 3o01A-2fezA:
21.53
3o01B-2fezA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 327
LEU A 313
THR A  57
 None
 0.65A 3oxcA-2fezA:
undetectable		 3oxcA-2fezA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 203
PRO A 206
THR A 246
THR A 233
 None
 1.06A 3q07A-2fezA:
undetectable		 3q07A-2fezA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 203
PRO A 206
THR A 246
THR A 233
 None
 1.04A 3q07B-2fezA:
undetectable		 3q07B-2fezA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  39
LEU A  42
VAL A  43
ILE A 105
 None
 0.90A 4oj4A-2fezA:
undetectable		 4oj4A-2fezA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 201
GLU A 200
VAL A 171
LYS A 170
 None
 1.33A 4p6vB-2fezA:
undetectable
4p6vE-2fezA:
undetectable		 4p6vB-2fezA:
22.81
4p6vE-2fezA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 155
ARG A  36
PRO A  33
 None
 0.69A 4wanC-2fezA:
undetectable		 4wanC-2fezA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 178
LEU A 211
ALA A 214
SER A 265
ALA A 262
 None
 1.18A 4zbrA-2fezA:
undetectable		 4zbrA-2fezA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_A_ACTA404_0
(PROTON-GATED ION
CHANNEL)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 211
ILE A 191
ARG A 230
TYR A 215
 None
 1.31A 4zzbA-2fezA:
3.5		 4zzbA-2fezA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA406_0
(PROTON-GATED ION
CHANNEL)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 211
ILE A 191
ARG A 230
TYR A 215
 None
 1.33A 4zzcA-2fezA:
4.0		 4zzcA-2fezA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB406_0
(PROTON-GATED ION
CHANNEL)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 211
ILE A 191
ARG A 230
TYR A 215
 None
 1.34A 4zzcB-2fezA:
4.3		 4zzcB-2fezA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 350
LEU A 303
PHE A 376
ARG A 309
LEU A 320
 None
 1.39A 5nd2B-2fezA:
undetectable		 5nd2B-2fezA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  15
ILE A  44
THR A 164
LEU A  19
LEU A 153
 None
 1.26A 5nfjB-2fezA:
undetectable		 5nfjB-2fezA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  15
ILE A  44
THR A 164
LEU A  19
LEU A 153
 None
 1.26A 5nfjC-2fezA:
undetectable		 5nfjC-2fezA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2fez PROBABLE REGULATORY
PROTEIN EMBR
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 228
ARG A 229
THR A 233
 None
 0.91A 5z84J-2fezA:
undetectable		 5z84J-2fezA:
10.88