SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ffh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 10 LEU A  86
ALA A 220
ALA A 256
LEU A   5
PHE A 282
 None
 1.10A 1rlbE-2ffhA:
undetectable		 1rlbE-2ffhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 12 LEU A 326
GLU A 373
LEU A 380
ARG A 387
PHE A 406
 None
 1.24A 1s9pB-2ffhA:
undetectable		 1s9pB-2ffhA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 9 LEU A   9
LEU A  82
ALA A  59
LEU A  31
PHE A  51
 None
 1.25A 1tbfA-2ffhA:
undetectable		 1tbfA-2ffhA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 12 ALA A 256
ASP A 250
GLY A 253
GLY A 254
ALA A 220
 None
 1.15A 2c49A-2ffhA:
2.5		 2c49A-2ffhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 12 ALA A 255
ASP A 250
GLY A 253
GLY A 254
GLN A 330
 None
 0.93A 2pkmA-2ffhA:
3.1		 2pkmA-2ffhA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 12 LEU A 242
LEU A 244
ALA A 259
VAL A 262
THR A 222
 None
 1.18A 2qo6A-2ffhA:
undetectable		 2qo6A-2ffhA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 6 PHE A  51
LEU A   5
ALA A 288
LEU A  86
ALA A  85
 None
 1.36A 2vcvK-2ffhA:
undetectable		 2vcvK-2ffhA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		4 / 5 VAL A 217
VAL A 243
PHE A 102
ARG A 260
 None
 1.30A 3bjwH-2ffhA:
undetectable		 3bjwH-2ffhA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		4 / 5 VAL A 217
VAL A 243
PHE A 102
ARG A 260
 None
 1.26A 3bjwB-2ffhA:
1.7		 3bjwB-2ffhA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 10 LEU A  86
VAL A  43
ALA A 288
ILE A 291
LEU A   5
 None
 1.23A 3fl9F-2ffhA:
4.4		 3fl9F-2ffhA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		4 / 8 ASP A 250
LEU A 287
LEU A 247
SER A 299
 None
None
None
CD  A 701 ( 4.9A)
 0.92A 3lm8A-2ffhA:
undetectable
3lm8C-2ffhA:
undetectable		 3lm8A-2ffhA:
20.00
3lm8C-2ffhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		4 / 6 PHE A 282
LEU A 257
THR A 263
LEU A 244
 None
 0.99A 3t3zA-2ffhA:
undetectable		 3t3zA-2ffhA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		4 / 6 PHE A 282
LEU A 257
THR A 263
LEU A 244
 None
 0.93A 3t3zB-2ffhA:
undetectable		 3t3zB-2ffhA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		4 / 6 PHE A 282
LEU A 257
THR A 263
LEU A 244
 None
 0.99A 3t3zD-2ffhA:
undetectable		 3t3zD-2ffhA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 12 LEU A   5
LEU A   9
GLN A 224
VAL A  55
VAL A  47
 None
 1.19A 3w1wB-2ffhA:
2.6		 3w1wB-2ffhA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		3 / 3 GLN A 137
ASP A 195
GLN A 193
 None
 0.84A 4aztA-2ffhA:
2.6		 4aztA-2ffhA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		4 / 8 ASP A 187
VAL A 172
PHE A 102
LEU A 205
 None
 0.98A 4f8hA-2ffhA:
undetectable
4f8hB-2ffhA:
undetectable		 4f8hA-2ffhA:
22.40
4f8hB-2ffhA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		4 / 8 ASP A 187
VAL A 172
PHE A 102
LEU A 205
 None
 0.98A 4f8hB-2ffhA:
undetectable
4f8hC-2ffhA:
undetectable		 4f8hB-2ffhA:
22.40
4f8hC-2ffhA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		4 / 8 ASP A 187
VAL A 172
PHE A 102
LEU A 205
 None
 0.98A 4f8hC-2ffhA:
undetectable
4f8hD-2ffhA:
undetectable		 4f8hC-2ffhA:
22.40
4f8hD-2ffhA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		4 / 8 ASP A 187
VAL A 172
PHE A 102
LEU A 205
 None
 0.97A 4f8hD-2ffhA:
undetectable
4f8hE-2ffhA:
undetectable		 4f8hD-2ffhA:
22.40
4f8hE-2ffhA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		4 / 8 VAL A 172
PHE A 102
LEU A 205
ASP A 187
 None
 0.99A 4f8hA-2ffhA:
undetectable
4f8hE-2ffhA:
undetectable		 4f8hA-2ffhA:
22.40
4f8hE-2ffhA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 11 MET A 199
GLY A 391
ALA A 364
LEU A 367
ALA A 256
 None
 1.20A 4l6v1-2ffhA:
undetectable
4l6v6-2ffhA:
undetectable		 4l6v1-2ffhA:
19.63
4l6v6-2ffhA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 11 LEU A 257
LEU A   5
LEU A  86
VAL A  78
LEU A 292
 None
 1.12A 4p65C-2ffhA:
undetectable
4p65D-2ffhA:
undetectable
4p65J-2ffhA:
undetectable
4p65L-2ffhA:
undetectable		 4p65C-2ffhA:
4.72
4p65D-2ffhA:
6.36
4p65J-2ffhA:
6.36
4p65L-2ffhA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 11 LEU A  86
VAL A  78
LEU A 292
LEU A 257
LEU A   5
 None
 1.06A 4p65B-2ffhA:
undetectable
4p65D-2ffhA:
undetectable
4p65G-2ffhA:
undetectable
4p65H-2ffhA:
undetectable		 4p65B-2ffhA:
6.36
4p65D-2ffhA:
6.36
4p65G-2ffhA:
4.72
4p65H-2ffhA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 8 LEU A 244
ALA A 220
LEU A 287
LEU A  86
ALA A 255
 None
 1.15A 4z90A-2ffhA:
2.2
4z90B-2ffhA:
1.8
4z90C-2ffhA:
1.8
4z90D-2ffhA:
1.9
4z90E-2ffhA:
1.9		 4z90A-2ffhA:
21.31
4z90B-2ffhA:
21.31
4z90C-2ffhA:
21.31
4z90D-2ffhA:
21.31
4z90E-2ffhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		3 / 3 ARG A 181
LYS A 175
GLU A 179
 None
 0.79A 5d0yA-2ffhA:
3.0		 5d0yA-2ffhA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 12 LEU A   5
LEU A 292
ILE A  34
ALA A  37
ILE A  13
 None
 1.26A 5eypB-2ffhA:
3.5		 5eypB-2ffhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 12 LEU A   5
LEU A 292
ILE A  34
ALA A  37
ILE A  13
 None
 1.22A 5nm5B-2ffhA:
3.9		 5nm5B-2ffhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		4 / 7 LEU A 131
LEU A 103
THR A 112
ALA A 115
 None
None
SO4  A 750 (-4.1A)
None
 0.77A 5o96C-2ffhA:
2.4		 5o96C-2ffhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 10 LEU A 131
LEU A 185
LEU A 103
THR A 112
ALA A 115
 None
None
None
SO4  A 750 (-4.1A)
None
 0.90A 5o96G-2ffhA:
undetectable
5o96H-2ffhA:
undetectable		 5o96G-2ffhA:
21.69
5o96H-2ffhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		4 / 5 GLU A  80
LYS A  83
GLU A  84
GLU A  58
 None
 1.50A 5onlA-2ffhA:
0.3		 5onlA-2ffhA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 12 LEU A   5
LEU A 292
ILE A  34
ALA A  37
ILE A  13
 None
 1.23A 5xiwD-2ffhA:
undetectable		 5xiwD-2ffhA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		3 / 3 TYR A  79
ALA A  85
LEU A  86
 None
 0.58A 6ag0C-2ffhA:
undetectable		 6ag0C-2ffhA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		4 / 6 MET A 199
GLY A 391
ALA A 364
LEU A 367
 None
 1.05A 6fosA-2ffhA:
1.3		 6fosA-2ffhA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2ffh PROTEIN (FFH)
(Thermus
aquaticus) 		5 / 10 MET A 199
GLY A 391
ALA A 364
LEU A 367
LEU A 247
 None
 1.21A 6hqbA-2ffhA:
undetectable
6hqbJ-2ffhA:
undetectable		 6hqbA-2ffhA:
9.62
6hqbJ-2ffhA:
8.88