SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ffi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		3 / 3 ALA A 215
VAL A 198
TRP A 233
 None
 0.89A 1av2A-2ffiA:
undetectable
1av2B-2ffiA:
undetectable		 1av2A-2ffiA:
5.68
1av2B-2ffiA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		4 / 8 GLY A 190
GLY A 192
TYR A 226
VAL A 140
 None
 0.81A 1dbbH-2ffiA:
undetectable
1dbbL-2ffiA:
undetectable		 1dbbH-2ffiA:
19.45
1dbbL-2ffiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		5 / 12 VAL A 106
GLY A 105
LEU A  76
GLY A 108
VAL A  21
 None
 1.22A 1fduC-2ffiA:
undetectable		 1fduC-2ffiA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		4 / 7 PRO A 150
VAL A 151
LEU A 188
VAL A 146
 None
 0.93A 1jgsA-2ffiA:
undetectable		 1jgsA-2ffiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		4 / 8 ILE A 201
PHE A 168
VAL A 196
SER A  17
 None
 1.08A 1kb9A-2ffiA:
undetectable
1kb9C-2ffiA:
undetectable
1kb9D-2ffiA:
undetectable
1kb9E-2ffiA:
undetectable		 1kb9A-2ffiA:
20.54
1kb9C-2ffiA:
21.75
1kb9D-2ffiA:
21.36
1kb9E-2ffiA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		3 / 3 PHE A  64
TYR A  38
PRO A  36
 None
 1.17A 1mcnA-2ffiA:
undetectable
1mcnB-2ffiA:
undetectable
1mcnP-2ffiA:
undetectable		 1mcnA-2ffiA:
22.26
1mcnB-2ffiA:
22.26
1mcnP-2ffiA:
0.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		3 / 3 ALA A 215
VAL A 198
TRP A 233
 None
 0.88A 1w5uA-2ffiA:
undetectable
1w5uB-2ffiA:
undetectable		 1w5uA-2ffiA:
5.68
1w5uB-2ffiA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		3 / 3 TRP A 233
ALA A 215
VAL A 198
 None
 0.97A 1w5uA-2ffiA:
undetectable
1w5uB-2ffiA:
undetectable		 1w5uA-2ffiA:
5.68
1w5uB-2ffiA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		5 / 10 PHE A 168
ALA A 215
ARG A 216
LEU A 212
LEU A 186
 None
 1.10A 2bxqA-2ffiA:
undetectable		 2bxqA-2ffiA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		3 / 3 TRP A 233
ALA A 215
VAL A 198
 None
 0.94A 2izqC-2ffiA:
undetectable
2izqD-2ffiA:
undetectable		 2izqC-2ffiA:
5.68
2izqD-2ffiA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		4 / 6 LEU A 142
LEU A 111
ILE A 149
ARG A 144
 None
 1.05A 2rlfA-2ffiA:
undetectable
2rlfB-2ffiA:
undetectable		 2rlfA-2ffiA:
9.76
2rlfB-2ffiA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		3 / 3 TRP A 233
ALA A 215
VAL A 198
 None
 0.94A 3l8lC-2ffiA:
undetectable
3l8lD-2ffiA:
undetectable		 3l8lC-2ffiA:
5.68
3l8lD-2ffiA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		5 / 12 GLY A 105
GLY A  85
LEU A  73
LEU A  72
GLU A 100
 None
 1.13A 4lg1B-2ffiA:
undetectable		 4lg1B-2ffiA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		5 / 12 ILE A 133
LEU A 129
ARG A 110
HIS A  18
GLY A 108
 None
None
PO4  A 301 (-2.3A)
PO4  A 301 (-4.1A)
None
 1.27A 5k7uA-2ffiA:
undetectable		 5k7uA-2ffiA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		5 / 12 PHE A 277
PHE A 182
ALA A 221
LEU A 231
MET A 232
 None
 1.25A 5tl8A-2ffiA:
undetectable		 5tl8A-2ffiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE
(Pseudomonas
putida) 		4 / 5 HIS A  20
ASP A 236
HIS A  18
ARG A 203
 PO4  A 301 (-3.8A)
PO4  A 301 (-3.2A)
PO4  A 301 (-4.1A)
PO4  A 301 (-4.1A)
 1.09A 6dchA-2ffiA:
undetectable		 6dchA-2ffiA:
21.01