SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ffj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 2ffj CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 9 ILE A  29
LEU A  37
VAL A  15
GLY A  13
ALA A  19
 None
 1.31A 1e7aA-2ffjA:
2.8		 1e7aA-2ffjA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 2ffj CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 191
ASP A 194
LEU A  11
ASN A 215
ASN A 248
 None
 1.10A 1likA-2ffjA:
2.9		 1likA-2ffjA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2ffj CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 LEU A 171
VAL A 155
LEU A 240
ALA A 243
 None
 0.91A 3uniB-2ffjA:
undetectable		 3uniB-2ffjA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2ffj CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 194
LEU A  11
GLY A 221
ASN A 248
GLY A 245
 None
None
None
None
SO4  A 291 (-3.4A)
 1.08A 3uq6B-2ffjA:
undetectable		 3uq6B-2ffjA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2ffj CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 THR A 102
VAL A 106
GLU A 174
 None
 0.76A 3v4tA-2ffjA:
undetectable
3v4tD-2ffjA:
undetectable		 3v4tA-2ffjA:
24.59
3v4tD-2ffjA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2ffj CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 194
LEU A  11
GLY A 221
ASN A 248
GLY A 245
 None
None
None
None
SO4  A 291 (-3.4A)
 1.02A 3vaqB-2ffjA:
3.5		 3vaqB-2ffjA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2ffj CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 194
LEU A  11
GLY A 221
ASN A 248
GLY A 245
 None
None
None
None
SO4  A 291 (-3.4A)
 1.02A 3vasB-2ffjA:
2.6		 3vasB-2ffjA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 2ffj CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 194
LEU A  11
GLY A 221
ASN A 248
GLY A 245
 None
None
None
None
SO4  A 291 (-3.4A)
 1.05A 4n09A-2ffjA:
3.6		 4n09A-2ffjA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2ffj CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 6 VAL A  15
ALA A  19
VAL A  61
TYR A  62
 None
 1.05A 5i8fA-2ffjA:
undetectable		 5i8fA-2ffjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2ffj CONSERVED
HYPOTHETICAL PROTEIN
(Archaeoglobus
fulgidus) 		4 / 7 ARG A  14
LEU A  65
TYR A  71
VAL A  61
 SO4  A 290 (-2.7A)
None
SO4  A 290 ( 4.9A)
None
 1.21A 6g2pA-2ffjA:
2.2		 6g2pA-2ffjA:
22.76