SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ffu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 9 ARG A 116
LEU A 112
GLU A 228
ALA A 151
HIS A 226
 None
None
None
None
MN  A 600 ( 3.4A)
 1.45A 1mj2A-2ffuA:
undetectable		 1mj2A-2ffuA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
ILE A 351
VAL A 357
ILE A 253
 None
 0.89A 1muiB-2ffuA:
undetectable		 1muiB-2ffuA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 5 ASP A 115
VAL A 157
SER A 158
GLN A  83
 None
 1.38A 1n2xB-2ffuA:
2.1		 1n2xB-2ffuA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 6 LEU A 278
TRP A 276
LEU A 437
PHE A 426
 None
 1.45A 1ru9H-2ffuA:
undetectable
1ru9L-2ffuA:
undetectable		 1ru9H-2ffuA:
15.98
1ru9L-2ffuA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 6 LEU A 278
TRP A 276
LEU A 437
PHE A 426
 None
 1.48A 1rukH-2ffuA:
undetectable
1rukL-2ffuA:
undetectable		 1rukH-2ffuA:
15.98
1rukL-2ffuA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
ILE A 351
VAL A 357
ILE A 253
 None
 1.00A 1sdtB-2ffuA:
undetectable		 1sdtB-2ffuA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
VAL A 249
VAL A 357
ILE A 253
 None
 0.97A 2f8gA-2ffuA:
undetectable		 2f8gA-2ffuA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 11 GLY A 308
ALA A 307
ILE A 351
VAL A 357
ILE A 253
 None
 0.91A 2fxeB-2ffuA:
undetectable		 2fxeB-2ffuA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
ILE A 351
VAL A 357
ILE A 253
 None
 0.89A 2o4kB-2ffuA:
undetectable		 2o4kB-2ffuA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
ILE A 351
VAL A 357
ILE A 253
 None
 0.82A 2o4sB-2ffuA:
undetectable		 2o4sB-2ffuA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
ILE A 351
VAL A 357
ILE A 253
 None
 0.88A 2r5pB-2ffuA:
undetectable		 2r5pB-2ffuA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
ILE A 351
VAL A 357
ILE A 253
 None
 0.88A 2r5pD-2ffuA:
undetectable		 2r5pD-2ffuA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 ALA A 148
GLU A 147
PHE A 361
SER A 225
THR A 155
 None
None
None
UDP  A 601 (-2.9A)
None
 1.28A 2xffA-2ffuA:
0.0		 2xffA-2ffuA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
VAL A 249
VAL A 357
ILE A 253
 None
 0.95A 3cyxA-2ffuA:
undetectable		 3cyxA-2ffuA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 ILE A 168
VAL A 312
PHE A 311
SER A 355
VAL A 357
 None
 1.25A 3iw1A-2ffuA:
undetectable		 3iw1A-2ffuA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 9 GLY A 308
ALA A 307
VAL A 249
VAL A 357
ILE A 253
 None
 0.89A 3oxvA-2ffuA:
undetectable		 3oxvA-2ffuA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
ILE A 351
VAL A 312
ILE A 253
 None
 1.05A 3oxxC-2ffuA:
undetectable		 3oxxC-2ffuA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
ILE A 351
VAL A 357
ILE A 253
 None
 0.95A 3oxxC-2ffuA:
undetectable		 3oxxC-2ffuA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 GLY A 308
ALA A 307
VAL A 249
VAL A 357
ILE A 253
 None
 1.00A 3oxxC-2ffuA:
undetectable		 3oxxC-2ffuA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 5 VAL A 468
LEU A 550
ILE A 508
VAL A 490
 None
 0.95A 4a9kB-2ffuA:
undetectable		 4a9kB-2ffuA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 11 PHE A 144
GLY A  88
ASP A 110
ARG A 101
ARG A 362
 None
None
None
None
UDP  A 601 (-4.1A)
 1.38A 4dx7A-2ffuA:
0.0		 4dx7A-2ffuA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 6 SER A 489
GLU A 487
GLY A 469
ASP A 458
 None
 0.93A 5cdnC-2ffuA:
undetectable
5cdnD-2ffuA:
undetectable		 5cdnC-2ffuA:
22.24
5cdnD-2ffuA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 LEU A 173
ALA A 151
SER A 109
THR A 143
ARG A 197
 None
None
None
UDP  A 601 (-3.8A)
None
 1.30A 5hnzB-2ffuA:
undetectable		 5hnzB-2ffuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		5 / 12 ALA A 151
GLY A 358
ALA A 148
ARG A 149
TYR A  86
 None
 1.18A 5zvgB-2ffuA:
undetectable		 5zvgB-2ffuA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 6 GLY A  88
ASP A 110
SER A 150
ARG A 149
 None
 1.12A 6dwdA-2ffuA:
undetectable
6dwdC-2ffuA:
undetectable		 6dwdA-2ffuA:
23.06
6dwdC-2ffuA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		3 / 3 LEU A 415
GLN A 412
LYS A 393
 None
 0.97A 6exiB-2ffuA:
2.1		 6exiB-2ffuA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		3 / 3 LEU A 415
GLN A 412
LYS A 393
 None
 0.95A 6exiA-2ffuA:
2.3		 6exiA-2ffuA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens) 		4 / 6 ARG A 197
SER A 178
ARG A 149
THR A  90
 None
 1.12A 6ma6A-2ffuA:
undetectable		 6ma6A-2ffuA:
9.15