SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fg1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257
(Bacteroides
thetaiotaomicron) 		5 / 11 ALA A  49
GLU A  47
ASN A  26
ASN A  78
TRP A  53
 None
 1.13A 1n6cA-2fg1A:
undetectable		 1n6cA-2fg1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 117
GLY A  17
GLY A  15
 None
 0.45A 3bogA-2fg1A:
undetectable
3bogC-2fg1A:
undetectable		 3bogA-2fg1A:
undetectable
3bogC-2fg1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257
(Bacteroides
thetaiotaomicron) 		3 / 3 MET A  79
VAL A  20
GLU A 106
 None
 0.82A 3c6gA-2fg1A:
undetectable		 3c6gA-2fg1A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A  20
ALA A  10
LEU A  39
ALA A  38
VAL A 107
 None
 0.98A 3fc6C-2fg1A:
undetectable		 3fc6C-2fg1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257
(Bacteroides
thetaiotaomicron) 		4 / 6 GLY A  17
SER A 117
LEU A  74
HIS A 119
 None
 0.80A 3o9mB-2fg1A:
2.6		 3o9mB-2fg1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257
(Bacteroides
thetaiotaomicron) 		4 / 7 VAL A 118
LEU A 104
MET A 135
ILE A 139
 None
 0.80A 3rfmA-2fg1A:
undetectable		 3rfmA-2fg1A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257
(Bacteroides
thetaiotaomicron) 		5 / 11 ALA A  49
GLU A  47
ASN A  26
ASN A  78
TRP A  53
 None
 1.17A 4jdsC-2fg1A:
undetectable		 4jdsC-2fg1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257
(Bacteroides
thetaiotaomicron) 		5 / 11 ALA A  49
GLU A  47
ASN A  26
ASN A  78
TRP A  53
 None
 1.16A 4jdsD-2fg1A:
undetectable		 4jdsD-2fg1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A  49
GLU A  47
ASN A  26
ASN A  78
TRP A  53
 None
 1.18A 4jlgA-2fg1A:
undetectable		 4jlgA-2fg1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257
(Bacteroides
thetaiotaomicron) 		5 / 11 ALA A  49
GLU A  47
ASN A  26
ASN A  78
TRP A  53
 None
 1.18A 5ayfA-2fg1A:
undetectable		 5ayfA-2fg1A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257
(Bacteroides
thetaiotaomicron) 		4 / 7 VAL A  18
ILE A 148
GLY A  81
ALA A  77
 None
 0.88A 6hd6B-2fg1A:
undetectable		 6hd6B-2fg1A:
20.00