SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 12 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.33A 1q23B-2fg5A:
undetectable		 1q23B-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 10 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.33A 1q23E-2fg5A:
undetectable		 1q23E-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 11 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.33A 1q23F-2fg5A:
undetectable		 1q23F-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 12 PHE A  56
LEU A  10
VAL A  82
VAL A 112
ALA A  80
 None
 1.24A 1q23H-2fg5A:
undetectable
1q23I-2fg5A:
undetectable		 1q23H-2fg5A:
17.33
1q23I-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 11 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.35A 1q23I-2fg5A:
undetectable		 1q23I-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 10 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.31A 1q23K-2fg5A:
undetectable		 1q23K-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 11 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.42A 1q23L-2fg5A:
undetectable		 1q23L-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		3 / 3 GLU A 127
GLU A 146
LEU A  96
 None
 0.74A 1v8bB-2fg5A:
3.1		 1v8bB-2fg5A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 12 THR A  37
GLY A  17
GLY A  15
GLY A  63
ASP A 121
 MG  A 301 ( 3.2A)
GNP  A 302 (-3.1A)
GNP  A 302 (-3.7A)
GNP  A 302 (-3.2A)
GNP  A 302 (-2.9A)
 1.04A 2b25A-2fg5A:
undetectable		 2b25A-2fg5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 9 ALA A 116
GLY A 161
ILE A 162
VAL A  22
ILE A  21
 None
 1.01A 2q5kA-2fg5A:
undetectable		 2q5kA-2fg5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		3 / 3 LEU A 103
TRP A  99
GLY A  12
 None
 0.80A 3l35A-2fg5A:
undetectable
3l35H-2fg5A:
undetectable		 3l35A-2fg5A:
12.23
3l35H-2fg5A:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		3 / 3 LEU A 103
TRP A  99
GLY A  12
 None
 0.79A 3l35B-2fg5A:
undetectable
3l35K-2fg5A:
undetectable		 3l35B-2fg5A:
12.23
3l35K-2fg5A:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 9 ALA A 116
ILE A 155
GLY A 161
VAL A  22
ILE A  21
 None
 1.06A 3nu4A-2fg5A:
undetectable		 3nu4A-2fg5A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 12 ILE A 153
ASP A 121
GLY A  15
LEU A 122
ILE A  34
 None
GNP  A 302 (-2.9A)
GNP  A 302 (-3.7A)
GNP  A 302 (-4.2A)
GNP  A 302 (-4.2A)
 1.12A 3pwwA-2fg5A:
undetectable		 3pwwA-2fg5A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 12 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.39A 3u9fB-2fg5A:
undetectable
3u9fC-2fg5A:
undetectable		 3u9fB-2fg5A:
17.33
3u9fC-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 10 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.41A 3u9fE-2fg5A:
undetectable		 3u9fE-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 12 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.37A 3u9fH-2fg5A:
undetectable
3u9fI-2fg5A:
undetectable		 3u9fH-2fg5A:
17.33
3u9fI-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 10 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.39A 3u9fI-2fg5A:
undetectable		 3u9fI-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 12 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.40A 3u9fJ-2fg5A:
undetectable
3u9fK-2fg5A:
undetectable		 3u9fJ-2fg5A:
17.33
3u9fK-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 10 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.42A 3u9fK-2fg5A:
undetectable		 3u9fK-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 11 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.38A 3u9fN-2fg5A:
undetectable
3u9fO-2fg5A:
undetectable		 3u9fN-2fg5A:
17.33
3u9fO-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 9 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.36A 3u9fP-2fg5A:
undetectable		 3u9fP-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 10 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.36A 3u9fR-2fg5A:
undetectable		 3u9fR-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 12 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.38A 3u9fP-2fg5A:
undetectable
3u9fS-2fg5A:
undetectable		 3u9fP-2fg5A:
17.33
3u9fS-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		3 / 3 PHE A  56
VAL A  47
GLU A 156
 None
 0.75A 4fvqA-2fg5A:
undetectable		 4fvqA-2fg5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 12 GLY A 117
ALA A 116
GLY A  12
SER A  20
ILE A  21
 None
None
None
GNP  A 302 (-2.7A)
None
 0.79A 5t2zB-2fg5A:
undetectable		 5t2zB-2fg5A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 10 ALA A 116
GLY A 161
ILE A 162
VAL A  22
ILE A  21
 None
 0.97A 6dj2A-2fg5A:
undetectable		 6dj2A-2fg5A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 11 ILE A  58
ALA A 114
LEU A 158
GLY A 161
PHE A  56
 None
 1.28A 6ieyA-2fg5A:
4.2
6ieyB-2fg5A:
3.3		 6ieyA-2fg5A:
21.43
6ieyB-2fg5A:
21.43