SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fgc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 8 ILE A 174
LYS A 158
PHE A 162
GLY A 138
 None
 0.74A 1os6A-2fgcA:
undetectable		 1os6A-2fgcA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 7 LEU A 132
GLN A 131
PHE A 130
LEU A 166
 None
 1.04A 1v55P-2fgcA:
undetectable
1v55W-2fgcA:
undetectable		 1v55P-2fgcA:
19.39
1v55W-2fgcA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 7 LEU A 132
GLN A 131
PHE A 130
LEU A 166
 None
 1.08A 2dysP-2fgcA:
undetectable
2dysW-2fgcA:
undetectable		 2dysP-2fgcA:
19.39
2dysW-2fgcA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 7 LEU A 132
GLN A 131
PHE A 130
LEU A 166
 None
 1.03A 2eijP-2fgcA:
undetectable
2eijW-2fgcA:
undetectable		 2eijP-2fgcA:
19.39
2eijW-2fgcA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 6 LEU A 132
GLN A 131
PHE A 130
LEU A 166
 None
 1.03A 2einP-2fgcA:
undetectable
2einW-2fgcA:
undetectable		 2einP-2fgcA:
19.39
2einW-2fgcA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 6 LEU A 132
GLN A 131
PHE A 130
LEU A 166
 None
 1.00A 2zxwP-2fgcA:
undetectable
2zxwW-2fgcA:
undetectable		 2zxwP-2fgcA:
19.39
2zxwW-2fgcA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 7 LEU A 132
GLN A 131
PHE A 130
LEU A 166
 None
 1.04A 3ag2C-2fgcA:
undetectable		 3ag2C-2fgcA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 8 ILE A 174
LYS A 158
PHE A 162
GLY A 138
 None
 0.68A 3selX-2fgcA:
undetectable		 3selX-2fgcA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 7 ILE A 174
LYS A 158
PHE A 162
GLY A 138
 None
 0.75A 3sj0X-2fgcA:
undetectable		 3sj0X-2fgcA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 6 ILE A 174
LYS A 158
PHE A 162
GLY A 138
 None
 0.68A 3sj1X-2fgcA:
undetectable		 3sj1X-2fgcA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 7 ILE A 174
LYS A 158
PHE A 162
GLY A 138
 None
 0.80A 4hajA-2fgcA:
undetectable		 4hajA-2fgcA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 8 ILE A 174
LYS A 158
PHE A 162
GLY A 138
 None
 0.76A 4hb6A-2fgcA:
undetectable		 4hb6A-2fgcA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 8 ILE A 174
LYS A 158
PHE A 162
GLY A 138
 None
 0.74A 4hb8A-2fgcA:
undetectable		 4hb8A-2fgcA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 7 ILE A 174
LYS A 158
PHE A 162
GLY A 138
 None
 0.75A 4hbfA-2fgcA:
undetectable		 4hbfA-2fgcA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		4 / 7 ILE A 174
LYS A 158
PHE A 162
GLY A 138
 None
 0.74A 4hc3A-2fgcA:
undetectable		 4hc3A-2fgcA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		3 / 3 ALA A 161
ASN A 164
LEU A 165
 None
 0.46A 5i1nC-2fgcA:
undetectable		 5i1nC-2fgcA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT
(Thermotoga
maritima) 		3 / 3 ALA A 161
ASN A 164
LEU A 165
 None
 0.39A 5i1pA-2fgcA:
undetectable		 5i1pA-2fgcA:
16.94