SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fge'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 LEU A 511
SER A 165
ASN A 162
 None
 0.80A 1bx4A-2fgeA:
undetectable		 1bx4A-2fgeA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 10 MET A 381
LEU A 384
LEU A 387
ALA A 388
LEU A 322
 None
 1.16A 1gwrA-2fgeA:
undetectable		 1gwrA-2fgeA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 8 THR A 887
GLY A 886
GLY A 893
PHE A 890
LEU A 891
 None
 1.42A 1jhvA-2fgeA:
undetectable		 1jhvA-2fgeA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 ASP A 244
PHE A 239
VAL A 251
 None
 0.72A 1kijB-2fgeA:
undetectable		 1kijB-2fgeA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 8 SER A 426
ASP A  56
ASN A  58
LEU A 440
 None
 0.98A 1lhvA-2fgeA:
undetectable		 1lhvA-2fgeA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 9 ALA A 959
TYR A 825
GLY A 818
GLY A 865
TYR A 821
 None
 1.11A 1ncwH-2fgeA:
1.2
1ncwL-2fgeA:
1.2		 1ncwH-2fgeA:
12.78
1ncwL-2fgeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 4 HIS A 247
VAL A 251
THR A 126
LEU A 132
 None
 0.92A 1oq5A-2fgeA:
undetectable		 1oq5A-2fgeA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 VAL A  60
ALA A 122
HIS A 105
 None
 0.65A 1q23C-2fgeA:
undetectable		 1q23C-2fgeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 VAL A  60
ALA A 122
HIS A 105
 None
 0.67A 1q23H-2fgeA:
undetectable		 1q23H-2fgeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 VAL A  60
ALA A 122
HIS A 105
 None
 0.58A 1q23L-2fgeA:
undetectable		 1q23L-2fgeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 9 ALA A 959
TYR A 825
GLY A 818
GLY A 865
TYR A 821
 None
 1.12A 1ru9H-2fgeA:
1.1
1ru9L-2fgeA:
0.0		 1ru9H-2fgeA:
12.78
1ru9L-2fgeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 10 ALA A 959
TYR A 825
GLY A 818
GLY A 865
TYR A 821
 None
 1.11A 1ruaH-2fgeA:
0.0
1ruaL-2fgeA:
0.0		 1ruaH-2fgeA:
12.78
1ruaL-2fgeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 9 ALA A 959
TYR A 825
GLY A 818
GLY A 865
TYR A 821
 None
 1.12A 1rulH-2fgeA:
1.2
1rulL-2fgeA:
1.2		 1rulH-2fgeA:
12.78
1rulL-2fgeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 9 ALA A 959
TYR A 825
GLY A 818
GLY A 865
TYR A 821
 None
 1.10A 1rumH-2fgeA:
1.2
1rumL-2fgeA:
1.0		 1rumH-2fgeA:
12.78
1rumL-2fgeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUP_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 9 ALA A 959
TYR A 825
GLY A 818
GLY A 865
TYR A 821
 None
 1.10A 1rupH-2fgeA:
1.1
1rupL-2fgeA:
0.7		 1rupH-2fgeA:
12.78
1rupL-2fgeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 5 VAL A 173
GLY A 172
VAL A 174
TRP A 157
 None
 0.97A 1tkqB-2fgeA:
undetectable		 1tkqB-2fgeA:
1.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 5 GLU A 467
THR A 383
LEU A 387
LEU A 384
 None
 1.15A 1u18B-2fgeA:
undetectable		 1u18B-2fgeA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 12 LEU A 843
ILE A 883
VAL A 849
GLY A 855
GLY A 856
 None
 0.84A 1uakA-2fgeA:
undetectable		 1uakA-2fgeA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 HIS A 247
ASP A 242
ASN A  58
 None
 0.73A 1wg8B-2fgeA:
undetectable		 1wg8B-2fgeA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 5 ALA A 700
ALA A 971
TYR A 813
GLN A 184
 None
 1.14A 1xl6A-2fgeA:
undetectable
1xl6B-2fgeA:
undetectable		 1xl6A-2fgeA:
15.14
1xl6B-2fgeA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 12 ALA A 396
GLY A 391
LEU A 325
MET A 326
LEU A 384
 None
 0.99A 1ya4A-2fgeA:
undetectable		 1ya4A-2fgeA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 LYS A 921
ASP A  56
ASP A 243
 None
 0.98A 2br4A-2fgeA:
undetectable		 2br4A-2fgeA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 12 ALA A 110
HIS A  81
HIS A  77
GLU A 177
TYR A 854
 None
ZN  A 996 (-3.2A)
ZN  A 996 (-3.4A)
ZN  A 996 (-2.2A)
None
 0.49A 2c6nA-2fgeA:
undetectable		 2c6nA-2fgeA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 PHE A 677
VAL A 734
TRP A 738
 None
 0.61A 2cc8A-2fgeA:
undetectable		 2cc8A-2fgeA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 PHE A 677
VAL A 734
TRP A 738
 None
 0.61A 2ccbA-2fgeA:
undetectable		 2ccbA-2fgeA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 7 THR A 577
LEU A 780
VAL A 776
VAL A 646
 None
 1.07A 2cppA-2fgeA:
undetectable		 2cppA-2fgeA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 12 PHE A 581
LEU A 753
ILE A 583
CYH A 598
VAL A 627
 None
 1.21A 2g72B-2fgeA:
undetectable		 2g72B-2fgeA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 12 LYS A 951
PHE A 953
THR A 908
ILE A 905
LEU A 901
 None
 1.06A 2oipE-2fgeA:
undetectable		 2oipE-2fgeA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 12 LEU A 327
LEU A 347
SER A 341
LEU A 379
VAL A 376
 None
 1.27A 2po7B-2fgeA:
undetectable		 2po7B-2fgeA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 5 LEU A 540
GLY A 543
ILE A 905
ILE A 906
 None
 0.85A 2q9rA-2fgeA:
undetectable		 2q9rA-2fgeA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 6 GLY A 815
GLY A 967
PHE A 988
PHE A 989
 None
 0.90A 2qx6A-2fgeA:
undetectable
2qx6B-2fgeA:
undetectable		 2qx6A-2fgeA:
12.00
2qx6B-2fgeA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 7 SER A 862
HIS A 863
ARG A 635
TYR A 832
 None
 1.45A 2vmyA-2fgeA:
undetectable
2vmyB-2fgeA:
undetectable		 2vmyA-2fgeA:
18.32
2vmyB-2fgeA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 PHE A 677
VAL A 734
TRP A 738
 None
 0.60A 2vx9A-2fgeA:
undetectable		 2vx9A-2fgeA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 MET A 651
VAL A 776
GLU A 578
 None
 0.84A 2x9gA-2fgeA:
undetectable		 2x9gA-2fgeA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 7 ASP A 244
VAL A 251
ARG A 250
TYR A 130
 None
 1.14A 2yfbA-2fgeA:
undetectable		 2yfbA-2fgeA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 7 ASP A 433
ARG A 236
ARG A  66
ILE A 270
 None
None
None
CL  A 997 ( 4.2A)
 1.05A 2yfbA-2fgeA:
undetectable		 2yfbA-2fgeA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 6 ASP A 244
VAL A 251
ARG A 250
TYR A 130
 None
 1.11A 2yfbB-2fgeA:
undetectable		 2yfbB-2fgeA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 6 ASP A 433
ARG A 236
ARG A  66
ILE A 270
 None
None
None
CL  A 997 ( 4.2A)
 1.05A 2yfbB-2fgeA:
undetectable		 2yfbB-2fgeA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 12 LEU A 666
GLN A 667
ILE A 644
LEU A 752
PHE A 597
 None
 0.93A 3datA-2fgeA:
undetectable		 3datA-2fgeA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 11 CYH A 758
LEU A 783
ALA A 754
LEU A 752
VAL A 579
 None
 1.25A 3e22B-2fgeA:
undetectable		 3e22B-2fgeA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 11 CYH A 758
LEU A 783
ALA A 754
LEU A 752
VAL A 579
 None
 1.27A 3e22D-2fgeA:
undetectable		 3e22D-2fgeA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 5 PRO A 784
THR A 606
VAL A 669
LYS A 607
 None
 1.11A 3elzA-2fgeA:
undetectable		 3elzA-2fgeA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 TYR A 113
TYR A 432
ILE A 431
 None
 0.81A 3eteA-2fgeA:
undetectable
3eteB-2fgeA:
undetectable		 3eteA-2fgeA:
19.74
3eteB-2fgeA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 11 LEU A 843
ASP A 961
TRP A 842
GLY A 886
GLY A 888
 None
 1.10A 3gy3A-2fgeA:
undetectable		 3gy3A-2fgeA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 PHE A 107
TYR A 119
LEU A 104
 None
 0.72A 3keeB-2fgeA:
undetectable		 3keeB-2fgeA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		6 / 9 GLY A 653
ALA A 655
ASP A 657
ILE A 574
LEU A 769
VAL A 772
 None
 1.41A 3u7sB-2fgeA:
undetectable		 3u7sB-2fgeA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 5 LEU A 891
LEU A 894
LEU A 950
SER A 949
 None
 0.82A 3vhuA-2fgeA:
undetectable		 3vhuA-2fgeA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 6 LEU A 727
PRO A 592
GLN A 717
TYR A 723
 None
 1.24A 3vkxA-2fgeA:
undetectable		 3vkxA-2fgeA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 6 ILE A 470
VAL A 302
LEU A 300
ILE A 363
 None
 0.92A 4asdA-2fgeA:
undetectable		 4asdA-2fgeA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 12 LEU A 881
SER A 871
TYR A 884
ALA A 969
MET A 704
 None
 1.47A 4hwkC-2fgeA:
0.3		 4hwkC-2fgeA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 10 PHE A 956
GLY A 865
VAL A 962
ILE A 960
VAL A 963
 None
 1.11A 4jx1B-2fgeA:
undetectable		 4jx1B-2fgeA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 8 THR A 577
LEU A 780
VAL A 776
VAL A 646
 None
 1.03A 4l4eA-2fgeA:
undetectable		 4l4eA-2fgeA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 8 THR A 577
LEU A 780
VAL A 776
VAL A 646
 None
 1.01A 4l4fA-2fgeA:
undetectable		 4l4fA-2fgeA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 11 LEU A 596
SER A 684
VAL A 734
LEU A 593
LEU A 727
 None
 1.25A 4or0B-2fgeA:
undetectable		 4or0B-2fgeA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 7 ILE A 618
LEU A 661
ARG A 676
THR A 610
LEU A 609
 None
 1.43A 5b1aA-2fgeA:
1.4
5b1aJ-2fgeA:
undetectable		 5b1aA-2fgeA:
18.66
5b1aJ-2fgeA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 PRO A 287
LEU A 189
SER A 183
 None
 0.82A 5fsaB-2fgeA:
undetectable		 5fsaB-2fgeA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 6 LEU A 325
LEU A 319
PHE A 462
LEU A 449
 None
 0.90A 5gs4A-2fgeA:
undetectable		 5gs4A-2fgeA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		3 / 3 ASN A 303
SER A 349
SER A 350
 None
 0.74A 5gsnA-2fgeA:
undetectable		 5gsnA-2fgeA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 5 ASP A 882
ARG A 985
MET A 704
MET A 707
 None
 1.44A 5gwkA-2fgeA:
undetectable		 5gwkA-2fgeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 8 ILE A 625
GLY A 624
CYH A 664
ASN A 615
 None
 0.83A 5hieD-2fgeA:
undetectable		 5hieD-2fgeA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 7 PHE A 956
GLY A 865
VAL A 962
ILE A 960
VAL A 963
 None
 1.05A 5ik1A-2fgeA:
undetectable		 5ik1A-2fgeA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 12 GLY A 719
LYS A 643
ILE A 645
ASP A 582
GLY A 584
 None
 1.11A 5wwsB-2fgeA:
undetectable		 5wwsB-2fgeA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 12 LEU A 843
ILE A 883
VAL A 849
GLY A 855
GLY A 856
 None
 0.85A 5wyqA-2fgeA:
undetectable		 5wyqA-2fgeA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 6 TRP A 738
SER A 742
ARG A 749
GLU A 746
 None
 1.36A 5x7pB-2fgeA:
undetectable		 5x7pB-2fgeA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		5 / 7 ILE A 618
LEU A 661
ARG A 676
THR A 610
LEU A 609
 None
 1.45A 5xdxA-2fgeA:
1.3
5xdxJ-2fgeA:
undetectable		 5xdxA-2fgeA:
18.66
5xdxJ-2fgeA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 7 ARG A 942
ARG A 938
ALA A 831
GLN A 939
 None
 1.09A 6b89A-2fgeA:
undetectable		 6b89A-2fgeA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 8 ASP A 961
ILE A 960
ARG A 964
ARG A 892
 None
 1.17A 6hisA-2fgeA:
undetectable
6hisB-2fgeA:
undetectable		 6hisA-2fgeA:
6.55
6hisB-2fgeA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 8 ASP A 961
ILE A 960
ARG A 964
ARG A 892
 None
 1.17A 6hisB-2fgeA:
undetectable
6hisC-2fgeA:
undetectable		 6hisB-2fgeA:
6.55
6hisC-2fgeA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 8 ASP A 961
ILE A 960
ARG A 964
ARG A 892
 None
 1.17A 6hisC-2fgeA:
undetectable
6hisD-2fgeA:
undetectable		 6hisC-2fgeA:
6.55
6hisD-2fgeA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 8 ASP A 961
ILE A 960
ARG A 964
ARG A 892
 None
 1.17A 6hisD-2fgeA:
undetectable
6hisE-2fgeA:
undetectable		 6hisD-2fgeA:
6.55
6hisE-2fgeA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)
(Arabidopsis
thaliana) 		4 / 8 ASP A 961
ILE A 960
ARG A 964
ARG A 892
 None
 1.17A 6hisA-2fgeA:
undetectable
6hisE-2fgeA:
undetectable		 6hisA-2fgeA:
6.55
6hisE-2fgeA:
6.55