SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fgn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2fgn PHOSPHOLIPASE C
(Bacillus
cereus) 		5 / 12 TYR A 119
HIS A  69
HIS A  14
ASN A  12
TYR A  52
 None
ZN  A 246 (-3.3A)
ZN  A 248 (-3.3A)
None
None
 0.99A 1ituA-2fgnA:
undetectable		 1ituA-2fgnA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 2fgn PHOSPHOLIPASE C
(Bacillus
cereus) 		4 / 7 ALA A   3
ILE A  51
ASP A  55
ILE A  17
 None
None
ZN  A 246 (-2.6A)
None
 0.78A 1yc5A-2fgnA:
undetectable		 1yc5A-2fgnA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 2fgn PHOSPHOLIPASE C
(Bacillus
cereus) 		4 / 6 TYR A 145
ARG A 223
GLY A 221
LYS A 222
 None
 0.97A 2i30A-2fgnA:
undetectable		 2i30A-2fgnA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 2fgn PHOSPHOLIPASE C
(Bacillus
cereus) 		5 / 12 LEU A 117
GLY A 114
SER A 116
LEU A  47
HIS A  14
 None
None
None
None
ZN  A 248 (-3.3A)
 1.19A 3e23A-2fgnA:
undetectable		 3e23A-2fgnA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 2fgn PHOSPHOLIPASE C
(Bacillus
cereus) 		5 / 12 ILE A  51
ALA A  21
ARG A  44
LEU A  47
LEU A  40
 None
 1.27A 4pbhA-2fgnA:
undetectable		 4pbhA-2fgnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2fgn PHOSPHOLIPASE C
(Bacillus
cereus) 		4 / 8 ASN A  19
VAL A  37
LEU A  40
GLY A 114
 None
 0.79A 4r3aA-2fgnA:
undetectable		 4r3aA-2fgnA:
22.73