SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fgq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		4 / 6 GLY X 126
THR X 201
THR X 194
ILE X 162
 None
 0.92A 1gtnD-2fgqX:
undetectable
1gtnE-2fgqX:
undetectable		 1gtnD-2fgqX:
11.04
1gtnE-2fgqX:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		4 / 6 SER X 184
ALA X 185
SER X 186
ASN X 149
 None
 0.87A 1yvpB-2fgqX:
undetectable		 1yvpB-2fgqX:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		4 / 7 SER X 184
ALA X 185
SER X 186
ASN X 149
 None
 0.96A 2i91A-2fgqX:
undetectable		 2i91A-2fgqX:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		4 / 7 SER X 184
ALA X 185
SER X 186
ASN X 149
 None
 0.96A 2i91B-2fgqX:
undetectable		 2i91B-2fgqX:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		3 / 3 TYR X 171
GLU X 205
THR X 102
 None
None
MLT  X 700 (-2.9A)
 0.83A 2y7hB-2fgqX:
undetectable		 2y7hB-2fgqX:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		5 / 12 GLY X 151
GLY X 174
ARG X  89
GLU X  87
ALA X 177
 None
 1.06A 3g89A-2fgqX:
undetectable		 3g89A-2fgqX:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		3 / 3 ASN X  13
ASP X  64
ARG X 133
 None
CA  X 501 (-3.4A)
MLT  X 700 (-3.1A)
 0.90A 3k13C-2fgqX:
undetectable		 3k13C-2fgqX:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		4 / 5 TYR X 104
THR X 102
PHE X 115
LEU X 106
 None
MLT  X 700 (-2.9A)
None
None
 1.34A 3qelC-2fgqX:
undetectable		 3qelC-2fgqX:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		5 / 12 GLY X 131
ARG X 230
ILE X 162
GLY X 169
ALA X 195
 None
 1.02A 3sudC-2fgqX:
undetectable		 3sudC-2fgqX:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQE_B_DXCB1079_0
(PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		5 / 11 SER X 186
THR X 102
LEU X 101
TYR X 104
SER X 184
 None
MLT  X 700 (-2.9A)
None
None
None
 1.45A 3zqeA-2fgqX:
0.0
3zqeB-2fgqX:
undetectable		 3zqeA-2fgqX:
22.99
3zqeB-2fgqX:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		3 / 3 ARG X  42
ARG X  38
TRP X  56
 None
SO4  X 601 (-2.9A)
None
 1.34A 4cpzC-2fgqX:
undetectable		 4cpzC-2fgqX:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		3 / 3 ASP X 129
ARG X  92
THR X 194
 None
 0.88A 4i13A-2fgqX:
undetectable		 4i13A-2fgqX:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		4 / 8 GLY X  43
THR X  44
THR X   5
ARG X  42
 None
 1.02A 4k87A-2fgqX:
undetectable		 4k87A-2fgqX:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		4 / 6 ARG X 119
ASP X 202
GLY X 234
THR X 238
 None
 1.10A 4l1aB-2fgqX:
undetectable		 4l1aB-2fgqX:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		3 / 3 ASP X 129
ARG X  92
THR X 194
 None
 0.90A 4p3rA-2fgqX:
undetectable		 4p3rA-2fgqX:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		4 / 7 ALA X 190
ASP X  93
ARG X  89
GLU X  87
 None
 0.96A 5bs8A-2fgqX:
undetectable
5bs8B-2fgqX:
undetectable
5bs8C-2fgqX:
undetectable		 5bs8A-2fgqX:
20.87
5bs8B-2fgqX:
22.22
5bs8C-2fgqX:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		4 / 7 ALA X 190
ASP X  93
ARG X  89
GLU X  87
 None
 0.98A 5btdA-2fgqX:
undetectable
5btdB-2fgqX:
undetectable
5btdC-2fgqX:
undetectable		 5btdA-2fgqX:
20.87
5btdB-2fgqX:
22.22
5btdC-2fgqX:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		4 / 7 ALA X 190
ASP X  93
ARG X  89
GLU X  87
 None
 0.95A 5btdA-2fgqX:
undetectable
5btdC-2fgqX:
undetectable
5btdD-2fgqX:
undetectable		 5btdA-2fgqX:
20.87
5btdC-2fgqX:
20.87
5btdD-2fgqX:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		3 / 3 ASP X 179
SER X 103
TYR X 104
 None
 0.88A 5glmA-2fgqX:
undetectable		 5glmA-2fgqX:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		5 / 10 ALA X 287
THR X 286
GLY X 327
ALA X  34
SER X  35
 None
None
None
SO4  X 600 ( 4.7A)
SO4  X 601 ( 3.7A)
 1.35A 5l66K-2fgqX:
undetectable
5l66L-2fgqX:
undetectable		 5l66K-2fgqX:
20.54
5l66L-2fgqX:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		5 / 10 ALA X 287
THR X 286
GLY X 327
ALA X  34
SER X  35
 None
None
None
SO4  X 600 ( 4.7A)
SO4  X 601 ( 3.7A)
 1.34A 5l66Y-2fgqX:
undetectable
5l66Z-2fgqX:
undetectable		 5l66Y-2fgqX:
20.54
5l66Z-2fgqX:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		4 / 6 PHE X 228
GLY X 124
THR X 194
GLN X 192
 None
 0.71A 6ag0A-2fgqX:
undetectable		 6ag0A-2fgqX:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		4 / 6 PHE X 228
GLY X 124
THR X 194
GLN X 192
 None
 0.69A 6ag0C-2fgqX:
undetectable		 6ag0C-2fgqX:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2fgq OUTER MEMBRANE PORIN
PROTEIN 32
(Delftia
acidovorans) 		3 / 3 GLN X 325
TYR X 289
ASN X 291
 None
 0.97A 6dwdC-2fgqX:
undetectable		 6dwdC-2fgqX:
21.62