SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fgt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH
(Bacillus
subtilis) 		3 / 3 LYS A 125
TYR A 172
PRO A 161
 None
 0.82A 2j9cC-2fgtA:
undetectable		 2j9cC-2fgtA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH
(Bacillus
subtilis) 		5 / 12 ALA A 246
GLU A  53
TYR A 366
SER A 313
THR A 315
 None
 1.43A 2xffA-2fgtA:
undetectable		 2xffA-2fgtA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH
(Bacillus
subtilis) 		4 / 5 GLN A 319
PHE A 320
LEU A 142
PHE A 143
 None
 1.34A 3ablC-2fgtA:
undetectable
3ablJ-2fgtA:
undetectable		 3ablC-2fgtA:
18.53
3ablJ-2fgtA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH
(Bacillus
subtilis) 		5 / 12 GLY A 387
GLY A 388
VAL A 391
MET A 228
ILE A 409
 None
 1.25A 3h52B-2fgtA:
undetectable		 3h52B-2fgtA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH
(Bacillus
subtilis) 		4 / 6 MET A  68
ILE A  88
ILE A 158
LEU A 159
 None
 0.75A 3hegA-2fgtA:
undetectable		 3hegA-2fgtA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH
(Bacillus
subtilis) 		5 / 12 TYR A 176
PHE A 112
LEU A 159
LEU A 220
HIS A  71
 None
 1.37A 4j03A-2fgtA:
undetectable		 4j03A-2fgtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH
(Bacillus
subtilis) 		3 / 3 MET A 386
GLU A 390
LEU A 394
 None
 0.71A 4v2oB-2fgtA:
undetectable		 4v2oB-2fgtA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH
(Bacillus
subtilis) 		5 / 10 SER A 188
LEU A 126
LEU A 128
LEU A  92
TRP A  89
 None
 0.79A 4yiaA-2fgtA:
undetectable		 4yiaA-2fgtA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH
(Bacillus
subtilis) 		4 / 4 VAL A 340
ALA A 412
PHE A 334
PHE A 321
 None
 1.34A 6cbdA-2fgtA:
0.0		 6cbdA-2fgtA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH
(Bacillus
subtilis) 		5 / 11 ASP A 137
PHE A 139
ILE A 136
LEU A 173
LEU A 142
 None
 1.47A 6fgcA-2fgtA:
undetectable		 6fgcA-2fgtA:
10.74