SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fgy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 8 CYH A 173
ASP A 175
HIS A 242
CYH A 253
 ZN  A 620 (-2.2A)
ZN  A 620 ( 4.7A)
ZN  A 620 (-3.3A)
ZN  A 620 (-2.3A)
 0.19A 1ekjA-2fgyA:
9.2
1ekjB-2fgyA:
7.3		 1ekjA-2fgyA:
19.13
1ekjB-2fgyA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 8 CYH A 173
ASP A 175
HIS A 242
CYH A 253
 ZN  A 620 (-2.2A)
ZN  A 620 ( 4.7A)
ZN  A 620 (-3.3A)
ZN  A 620 (-2.3A)
 0.24A 1ekjA-2fgyA:
9.2
1ekjB-2fgyA:
7.3		 1ekjA-2fgyA:
19.13
1ekjB-2fgyA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 8 CYH A 173
ASP A 175
HIS A 242
CYH A 253
 ZN  A 620 (-2.2A)
ZN  A 620 ( 4.7A)
ZN  A 620 (-3.3A)
ZN  A 620 (-2.3A)
 0.22A 1ekjG-2fgyA:
7.3
1ekjH-2fgyA:
9.1		 1ekjG-2fgyA:
19.13
1ekjH-2fgyA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 6 CYH A 173
ASP A 175
HIS A 242
CYH A 253
 ZN  A 620 (-2.2A)
ZN  A 620 ( 4.7A)
ZN  A 620 (-3.3A)
ZN  A 620 (-2.3A)
 0.18A 1ekjG-2fgyA:
7.3
1ekjH-2fgyA:
9.1		 1ekjG-2fgyA:
19.13
1ekjH-2fgyA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		5 / 12 VAL A 432
ASN A 428
ILE A 402
TYR A 456
ILE A 454
 None
 1.05A 1fk6A-2fgyA:
undetectable		 1fk6A-2fgyA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 6 ASN A  59
ILE A 185
ASN A 375
THR A  54
 None
 1.19A 1h7xA-2fgyA:
undetectable		 1h7xA-2fgyA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 6 ASN A  59
ILE A 185
ASN A 375
THR A  54
 None
 1.20A 1h7xB-2fgyA:
3.1		 1h7xB-2fgyA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 6 ASN A  59
ILE A 185
ASN A 375
THR A  54
 None
 1.20A 1h7xC-2fgyA:
undetectable		 1h7xC-2fgyA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 6 ASN A  59
ILE A 185
ASN A 375
THR A  54
 None
 1.20A 1h7xD-2fgyA:
undetectable		 1h7xD-2fgyA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 8 LEU A 422
GLU A 427
ILE A 476
TYR A 456
 None
 0.97A 1qvtA-2fgyA:
undetectable		 1qvtA-2fgyA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		5 / 9 PHE A 159
GLY A 158
ASN A 227
VAL A 168
PHE A 165
 None
 1.24A 2drdA-2fgyA:
undetectable		 2drdA-2fgyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 6 TYR A 401
THR A 131
ALA A 134
PRO A 451
 None
 1.10A 2ql8A-2fgyA:
undetectable
2ql8B-2fgyA:
undetectable		 2ql8A-2fgyA:
14.00
2ql8B-2fgyA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		6 / 12 ILE A 302
ALA A 263
ASP A 260
ALA A 267
VAL A 304
LEU A 292
 None
 1.35A 2yqzA-2fgyA:
undetectable		 2yqzA-2fgyA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		6 / 12 ILE A 302
ALA A 263
ASP A 260
ALA A 267
VAL A 304
LEU A 292
 None
 1.35A 2yqzB-2fgyA:
undetectable		 2yqzB-2fgyA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		5 / 12 PRO A 307
ILE A 238
LEU A 291
LEU A 372
ILE A 302
 None
 1.10A 3a50D-2fgyA:
undetectable		 3a50D-2fgyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 8 GLY A 356
PHE A 367
PHE A 165
GLY A 311
 None
 0.88A 3ko0O-2fgyA:
3.3
3ko0Q-2fgyA:
2.9		 3ko0O-2fgyA:
10.89
3ko0Q-2fgyA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 5 ILE A 508
THR A 139
THR A 136
PHE A 408
 None
 1.17A 3snfA-2fgyA:
undetectable		 3snfA-2fgyA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		5 / 10 CYH A 173
ASP A 175
HIS A 242
CYH A 253
ALA A 255
 ZN  A 620 (-2.2A)
ZN  A 620 ( 4.7A)
ZN  A 620 (-3.3A)
ZN  A 620 (-2.3A)
None
 0.27A 3ucjA-2fgyA:
7.7		 3ucjA-2fgyA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		5 / 10 CYH A 173
ASP A 175
HIS A 242
CYH A 253
ALA A 255
 ZN  A 620 (-2.2A)
ZN  A 620 ( 4.7A)
ZN  A 620 (-3.3A)
ZN  A 620 (-2.3A)
None
 0.26A 3ucjB-2fgyA:
7.8		 3ucjB-2fgyA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 8 ASP A 423
ASP A 209
ASP A 169
GLU A 427
 None
 0.94A 4feuD-2fgyA:
0.4		 4feuD-2fgyA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 7 VAL A 304
ILE A 302
LEU A  53
LEU A 376
 None
 0.99A 4l1wA-2fgyA:
undetectable		 4l1wA-2fgyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		3 / 3 PRO A 109
VAL A  93
HIS A  92
 None
None
ZN  A 621 (-3.3A)
 0.81A 4pevC-2fgyA:
2.4		 4pevC-2fgyA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		3 / 3 LEU A  62
ASP A  67
ILE A 185
 None
 0.35A 4xi3D-2fgyA:
undetectable		 4xi3D-2fgyA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 6 ARG A 496
PHE A  73
GLU A 410
VAL A 411
 None
 1.31A 5h4dA-2fgyA:
undetectable		 5h4dA-2fgyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		5 / 12 HIS A 121
VAL A  96
ALA A 100
SER A 103
LEU A 104
 ZN  A 621 (-3.1A)
None
None
None
None
 1.07A 5kirB-2fgyA:
undetectable		 5kirB-2fgyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		6 / 12 LEU A 123
ILE A 126
GLY A 125
LEU A  88
ASN A 116
LEU A 112
 None
 1.12A 5nfjA-2fgyA:
undetectable		 5nfjA-2fgyA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 7 ARG A 414
LEU A 178
ALA A 198
GLN A 378
 None
 1.25A 6b89A-2fgyA:
undetectable		 6b89A-2fgyA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		5 / 12 GLY A 176
VAL A 295
ILE A 430
GLY A 435
ALA A 255
 None
 0.98A 6c2mD-2fgyA:
undetectable		 6c2mD-2fgyA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 2fgy CARBOXYSOME SHELL
POLYPEPTIDE
(Halothiobacillus
neapolitanus) 		4 / 6 ASP A 488
ASN A 478
LEU A 497
SER A 513
 None
 1.24A 6ekuA-2fgyA:
undetectable		 6ekuA-2fgyA:
22.77