SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fhd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2fhd DNA REPAIR PROTEIN
RHP9/CRB2
(Schizosaccharomy
ces
pombe) 		4 / 8 SER A 375
VAL A 408
MET A 395
SER A 393
 None
 1.15A 1kb9A-2fhdA:
undetectable
1kb9C-2fhdA:
undetectable
1kb9D-2fhdA:
undetectable
1kb9E-2fhdA:
undetectable		 1kb9A-2fhdA:
17.94
1kb9C-2fhdA:
16.81
1kb9D-2fhdA:
19.51
1kb9E-2fhdA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2fhd DNA REPAIR PROTEIN
RHP9/CRB2
(Schizosaccharomy
ces
pombe) 		5 / 10 PHE A 416
VAL A 424
ASP A 453
ILE A 473
VAL A 460
 None
 1.42A 2qboA-2fhdA:
undetectable		 2qboA-2fhdA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 2fhd DNA REPAIR PROTEIN
RHP9/CRB2
(Schizosaccharomy
ces
pombe) 		3 / 3 PRO A 379
LEU A 367
ARG A 489
 None
 0.86A 3aqiB-2fhdA:
undetectable		 3aqiB-2fhdA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2fhd DNA REPAIR PROTEIN
RHP9/CRB2
(Schizosaccharomy
ces
pombe) 		5 / 12 ASP A 453
ILE A 476
VAL A 460
VAL A 436
VAL A 424
 None
 1.13A 5dpdB-2fhdA:
undetectable		 5dpdB-2fhdA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2fhd DNA REPAIR PROTEIN
RHP9/CRB2
(Schizosaccharomy
ces
pombe) 		3 / 3 LYS A 363
SER A 492
SER A 494
 None
 1.09A 6gbfA-2fhdA:
undetectable		 6gbfA-2fhdA:
16.63