SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		4 / 7 TYR A   6
GLY A  11
TYR A 110
GLY A 204
 None
 0.47A 11gsB-2fheA:
25.4		 11gsB-2fheA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		4 / 7 TYR A 110
GLY A 204
TYR A   6
GLY A  11
 None
 0.76A 11gsB-2fheA:
25.4		 11gsB-2fheA:
31.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		4 / 6 PRO A  15
MET A 153
ALA A  98
GLU A  95
 None
 1.35A 1qhyA-2fheA:
undetectable		 1qhyA-2fheA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		4 / 5 LEU A  71
GLY A  24
ALA A  75
ILE A  74
 None
 0.82A 2aohB-2fheA:
undetectable		 2aohB-2fheA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		5 / 12 LEU A 125
LEU A 164
GLY A 104
SER A 109
ALA A  97
 None
 1.24A 2bm9B-2fheA:
undetectable		 2bm9B-2fheA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		4 / 8 LEU A 175
ILE A 182
ILE A  94
LEU A 158
 None
 0.77A 2o4nB-2fheA:
undetectable		 2o4nB-2fheA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		3 / 3 LEU A 185
TYR A  22
GLY A  24
 None
 0.36A 2ocuA-2fheA:
undetectable		 2ocuA-2fheA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		4 / 6 LEU A 202
MET A 179
MET A 129
LEU A 158
 None
 1.46A 2oz7A-2fheA:
undetectable		 2oz7A-2fheA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		3 / 3 MET A 179
GLU A 156
ASN A 203
 None
 1.08A 3a27A-2fheA:
undetectable		 3a27A-2fheA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		4 / 6 TRP A   7
ASN A 203
ALA A 207
HIS A 206
 GSH  A 233 (-3.9A)
None
None
None
 1.24A 3aruA-2fheA:
undetectable		 3aruA-2fheA:
16.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		4 / 8 TYR A   6
GLY A  11
TYR A 110
GLY A 204
 None
 0.54A 3n9jB-2fheA:
25.4		 3n9jB-2fheA:
31.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA503_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		4 / 6 SER A 148
TYR A 141
PHE A 178
PHE A 152
 None
 1.43A 4awuA-2fheA:
0.0		 4awuA-2fheA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		6 / 12 LEU A 136
PHE A 178
ILE A  94
GLY A 144
ILE A 182
VAL A 150
 None
 1.42A 4nkxB-2fheA:
undetectable		 4nkxB-2fheA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		4 / 7 THR A  83
GLY A  82
THR A  84
VAL A  91
 None
 0.94A 4qwpB-2fheA:
undetectable		 4qwpB-2fheA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		4 / 9 GLU A 183
LEU A 175
LEU A 169
ILE A 161
 None
 0.98A 4xtaA-2fheA:
undetectable		 4xtaA-2fheA:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		4 / 5 GLY A  11
LEU A  12
SER A 106
TYR A 110
 None
GSH  A 233 (-4.5A)
None
None
 0.68A 6ji6A-2fheA:
33.9		 6ji6A-2fheA:
59.45