SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fhk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE
(Methanopyrus
kandleri) 		5 / 8 ILE A 264
ILE A   8
GLU A   2
VAL A   6
ILE A 276
 None
 1.37A 1linA-2fhkA:
undetectable		 1linA-2fhkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE
(Methanopyrus
kandleri) 		5 / 9 ALA A 196
VAL A 193
GLY A 192
ILE A 246
ALA A 259
 K  A 701 (-4.8A)
K  A 701 (-4.9A)
None
None
None
 0.84A 2z0yB-2fhkA:
undetectable		 2z0yB-2fhkA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE
(Methanopyrus
kandleri) 		5 / 12 ILE A 171
GLN A 270
ALA A 267
ASN A   4
ILE A   3
 None
 1.19A 3ddyA-2fhkA:
undetectable		 3ddyA-2fhkA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE
(Methanopyrus
kandleri) 		5 / 11 VAL A 187
ALA A 186
GLY A 263
ALA A 278
TYR A 170
 None
 1.40A 3qxyB-2fhkA:
1.1
3qxyQ-2fhkA:
undetectable		 3qxyB-2fhkA:
20.35
3qxyQ-2fhkA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE
(Methanopyrus
kandleri) 		5 / 9 ILE A  25
ILE A  77
PHE A 158
LYS A 123
GLY A 121
 None
None
None
MFN  A 600 (-4.0A)
None
 1.41A 3sj4X-2fhkA:
undetectable		 3sj4X-2fhkA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE
(Methanopyrus
kandleri) 		4 / 6 LEU A  89
VAL A 120
VAL A  23
PHE A 152
 None
None
None
K  A 711 ( 4.8A)
 1.12A 3soaA-2fhkA:
undetectable		 3soaA-2fhkA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE
(Methanopyrus
kandleri) 		5 / 8 ILE A  25
ILE A  77
PHE A 158
LYS A 123
GLY A 121
 None
None
None
MFN  A 600 (-4.0A)
None
 1.41A 4hb6A-2fhkA:
undetectable		 4hb6A-2fhkA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE
(Methanopyrus
kandleri) 		4 / 8 ILE A  25
ILE A  77
PHE A 158
GLY A 121
 None
 0.85A 4hdlA-2fhkA:
undetectable		 4hdlA-2fhkA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE
(Methanopyrus
kandleri) 		4 / 8 ILE A  77
ILE A 160
PHE A 158
GLY A 121
 None
 0.93A 4hdlA-2fhkA:
undetectable		 4hdlA-2fhkA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE
(Methanopyrus
kandleri) 		5 / 9 ILE A  75
VAL A  73
ALA A 103
CYH A  96
ILE A  25
 None
None
K  A 711 (-4.2A)
None
None
 1.02A 4lbgB-2fhkA:
undetectable		 4lbgB-2fhkA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE
(Methanopyrus
kandleri) 		4 / 6 LEU A 295
ILE A 290
ALA A  13
THR A  11
 None
 0.68A 4zf8A-2fhkA:
undetectable		 4zf8A-2fhkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE
(Methanopyrus
kandleri) 		5 / 12 ALA A 112
ASP A  57
GLU A 194
THR A  74
MET A  76
 None
K  A 701 (-4.2A)
None
None
None
 1.30A 4zjoA-2fhkA:
4.3		 4zjoA-2fhkA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE
(Methanopyrus
kandleri) 		5 / 12 ILE A 248
GLY A 167
ALA A 259
PHE A 296
VAL A 262
 None
 1.23A 5hw4C-2fhkA:
undetectable		 5hw4C-2fhkA:
21.20