SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fhx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		4 / 8 ILE B 223
ASN B 200
GLY B 219
LEU B 217
 None
 0.89A 1dzmA-2fhxB:
undetectable		 1dzmA-2fhxB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		4 / 7 ALA B  45
PHE B  53
VAL B  55
VAL B  73
 None
 0.75A 1epbA-2fhxB:
undetectable		 1epbA-2fhxB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		4 / 8 ALA B  45
PHE B  53
VAL B  55
VAL B  73
 None
 0.64A 1epbB-2fhxB:
undetectable		 1epbB-2fhxB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		4 / 8 TYR B 128
GLY B 121
GLY B 123
GLY B 124
 None
 0.63A 1qzzA-2fhxB:
undetectable		 1qzzA-2fhxB:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		5 / 12 GLY B 132
ALA B 133
ILE B  82
VAL B  99
PRO B  86
 None
 0.91A 2rkgB-2fhxB:
undetectable		 2rkgB-2fhxB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		4 / 6 ILE B 260
MET B 299
ILE B 223
HIS B 263
 None
None
None
CSO  B 221 (-3.5A)
 1.09A 3eteA-2fhxB:
undetectable
3eteE-2fhxB:
undetectable		 3eteA-2fhxB:
19.50
3eteE-2fhxB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		4 / 5 ILE B 260
MET B 299
ILE B 223
HIS B 263
 None
None
None
CSO  B 221 (-3.5A)
 1.09A 3eteB-2fhxB:
undetectable
3eteC-2fhxB:
undetectable		 3eteB-2fhxB:
19.50
3eteC-2fhxB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		4 / 7 MET B 299
ILE B 223
HIS B 263
ILE B 260
 None
None
CSO  B 221 (-3.5A)
None
 1.10A 3eteD-2fhxB:
undetectable
3eteF-2fhxB:
undetectable		 3eteD-2fhxB:
19.50
3eteF-2fhxB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_2
(NEURAMINIDASE)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		4 / 5 ASP B 244
ARG B 247
ARG B 248
ILE B 304
 None
 1.29A 3sanA-2fhxB:
undetectable		 3sanA-2fhxB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_2
(NEURAMINIDASE)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		4 / 5 ASP B 244
ARG B 247
ARG B 248
ILE B 304
 None
 1.30A 3sanB-2fhxB:
undetectable		 3sanB-2fhxB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		5 / 11 PHE B  61
HIS B 263
PRO B  86
GLY B 123
ASN B  89
 None
CSO  B 221 (-3.5A)
None
None
None
 1.44A 3v3nA-2fhxB:
undetectable		 3v3nA-2fhxB:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		5 / 11 PHE B  61
PRO B  86
GLY B 123
GLU B 126
ASN B  89
 None
 1.31A 4a6nA-2fhxB:
undetectable		 4a6nA-2fhxB:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_A_X8ZA350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		5 / 9 TYR B  67
HIS B 118
ASP B 120
HIS B 196
HIS B 263
 None
ZN  B 317 (-3.2A)
ZN  B 317 ( 4.0A)
ZN  B 317 ( 3.2A)
CSO  B 221 (-3.5A)
 0.81A 4c1dA-2fhxB:
28.4		 4c1dA-2fhxB:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		6 / 10 TYR B  67
HIS B 116
HIS B 118
ASP B 120
HIS B 196
HIS B 263
 None
ZN  B 317 (-3.4A)
ZN  B 317 (-3.2A)
ZN  B 317 ( 4.0A)
ZN  B 317 ( 3.2A)
CSO  B 221 (-3.5A)
 0.85A 4c1dB-2fhxB:
28.5		 4c1dB-2fhxB:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		5 / 10 TYR B  67
HIS B 196
HIS B 118
ASP B 120
HIS B 263
 None
ZN  B 317 ( 3.2A)
ZN  B 317 (-3.2A)
ZN  B 317 ( 4.0A)
CSO  B 221 (-3.5A)
 1.45A 4c1dB-2fhxB:
28.5		 4c1dB-2fhxB:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		6 / 11 HIS B 116
HIS B 118
ASP B 120
HIS B 196
LYS B 224
HIS B 263
 ZN  B 317 (-3.4A)
ZN  B 317 (-3.2A)
ZN  B 317 ( 4.0A)
ZN  B 317 ( 3.2A)
AZI  B 402 (-2.9A)
CSO  B 221 (-3.5A)
 0.67A 4c1fA-2fhxB:
30.0
4c1fB-2fhxB:
5.3		 4c1fA-2fhxB:
36.47
4c1fB-2fhxB:
36.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		6 / 9 HIS B 116
HIS B 118
ASP B 120
HIS B 196
GLY B 232
HIS B 263
 ZN  B 317 (-3.4A)
ZN  B 317 (-3.2A)
ZN  B 317 ( 4.0A)
ZN  B 317 ( 3.2A)
AZI  B 402 ( 3.7A)
CSO  B 221 (-3.5A)
 0.70A 4c1hA-2fhxB:
29.0		 4c1hA-2fhxB:
32.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		4 / 8 HIS B 118
ASP B 120
HIS B 196
HIS B 263
 ZN  B 317 (-3.2A)
ZN  B 317 ( 4.0A)
ZN  B 317 ( 3.2A)
CSO  B 221 (-3.5A)
 0.56A 4exsB-2fhxB:
29.1		 4exsB-2fhxB:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		3 / 3 PHE B 180
VAL B 111
GLU B 134
 None
 0.80A 4fvqA-2fhxB:
undetectable		 4fvqA-2fhxB:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		4 / 8 HIS B 118
ASP B 120
HIS B 196
HIS B 263
 ZN  B 317 (-3.2A)
ZN  B 317 ( 4.0A)
ZN  B 317 ( 3.2A)
CSO  B 221 (-3.5A)
 0.54A 5a5zA-2fhxB:
28.9		 5a5zA-2fhxB:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		4 / 7 HIS B 196
LYS B 224
GLY B 232
HIS B 263
 ZN  B 317 ( 3.2A)
AZI  B 402 (-2.9A)
AZI  B 402 ( 3.7A)
CSO  B 221 (-3.5A)
 0.62A 5a5zC-2fhxB:
28.8		 5a5zC-2fhxB:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		5 / 10 GLY B 124
GLY B 123
GLU B  88
SER B  69
SER B  85
 None
 0.95A 5aqfA-2fhxB:
undetectable		 5aqfA-2fhxB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		4 / 7 PRO B 297
VAL B 300
ASN B 301
ILE B 304
 None
 0.71A 5bmvC-2fhxB:
undetectable		 5bmvC-2fhxB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		5 / 12 GLY B 132
ALA B 133
ILE B  82
VAL B  99
PRO B  86
 None
 0.90A 5t8hB-2fhxB:
undetectable		 5t8hB-2fhxB:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2fhx SPM-1
(Pseudomonas
aeruginosa) 		4 / 8 HIS B 118
ASP B 120
HIS B 196
HIS B 263
 ZN  B 317 (-3.2A)
ZN  B 317 ( 4.0A)
ZN  B 317 ( 3.2A)
CSO  B 221 (-3.5A)
 0.58A 5zj8A-2fhxB:
9.2		 5zj8A-2fhxB:
26.07