SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fi1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 9 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.47A 1dz8A-2fi1A:
undetectable		 1dz8A-2fi1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 9 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.50A 1dz8B-2fi1A:
undetectable		 1dz8B-2fi1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 10 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.50A 1o76A-2fi1A:
undetectable		 1o76A-2fi1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 9 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.49A 2a1nB-2fi1A:
0.0		 2a1nB-2fi1A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 9 LEU A  91
ILE A  94
LEU A 184
ARG A 185
ILE A 181
 None
 1.01A 2f78A-2fi1A:
undetectable		 2f78A-2fi1A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 9 LEU A  91
ILE A  94
LEU A 184
ARG A 185
ILE A 181
 None
 1.09A 2f7aA-2fi1A:
undetectable		 2f7aA-2fi1A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 10 LEU A  91
ILE A  94
LEU A 184
ARG A 185
ILE A 181
 None
 1.04A 2f8dA-2fi1A:
undetectable		 2f8dA-2fi1A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 10 LEU A  91
ILE A  94
LEU A 184
ARG A 185
ILE A 181
 None
 1.05A 2f8dB-2fi1A:
undetectable		 2f8dB-2fi1A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 7 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.45A 2feuB-2fi1A:
undetectable		 2feuB-2fi1A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 12 LEU A 103
PHE A 124
ILE A 158
LEU A  78
PRO A  81
 None
 1.16A 2hrcA-2fi1A:
1.6		 2hrcA-2fi1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 12 LEU A 103
PHE A 124
ILE A 158
LEU A  78
PRO A  81
 None
 1.14A 2hrcB-2fi1A:
2.9		 2hrcB-2fi1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 11 GLY A 168
ALA A 167
GLY A 159
ILE A 158
VAL A 128
 None
 0.92A 2nnpA-2fi1A:
undetectable		 2nnpA-2fi1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 12 LEU A 103
PHE A 124
ILE A 158
LEU A  78
PRO A  81
 None
 1.16A 2po7A-2fi1A:
2.8		 2po7A-2fi1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 12 LEU A 103
PHE A 124
ILE A 158
LEU A  78
PRO A  81
 None
 1.15A 2po7B-2fi1A:
2.3		 2po7B-2fi1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 8 LEU A 144
GLY A 168
LEU A 173
GLY A 155
ASP A   8
 None
 1.00A 2yfxA-2fi1A:
undetectable		 2yfxA-2fi1A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 8 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.49A 2zujA-2fi1A:
undetectable		 2zujA-2fi1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 7 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.49A 2zwuA-2fi1A:
undetectable		 2zwuA-2fi1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 7 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.50A 3fwiA-2fi1A:
undetectable		 3fwiA-2fi1A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 7 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.48A 3fwjA-2fi1A:
undetectable		 3fwjA-2fi1A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 10 LEU A  91
VAL A  87
ILE A 158
LEU A 184
THR A 118
 None
 1.12A 3jw5B-2fi1A:
2.9		 3jw5B-2fi1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 8 GLU A  30
TYR A  70
GLU A  77
ILE A  37
 None
 0.99A 3jz0B-2fi1A:
undetectable		 3jz0B-2fi1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 8 GLY A 168
ALA A 167
GLY A 159
ILE A 158
 None
 0.70A 3so9A-2fi1A:
undetectable		 3so9A-2fi1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 7 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.44A 3wrhA-2fi1A:
undetectable		 3wrhA-2fi1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 7 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.47A 3wrjA-2fi1A:
undetectable		 3wrjA-2fi1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 7 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.44A 3wrlA-2fi1A:
undetectable		 3wrlA-2fi1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 7 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.46A 3wrmA-2fi1A:
undetectable		 3wrmA-2fi1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 9 SER A  24
ALA A  27
GLU A  30
LEU A  78
ILE A  82
 None
 1.11A 4xtaA-2fi1A:
undetectable		 4xtaA-2fi1A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 7 GLY A 168
ALA A 167
GLY A 159
ILE A 158
 None
 0.65A 5kqyB-2fi1A:
undetectable		 5kqyB-2fi1A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 12 ASP A  93
LEU A 115
HIS A 101
ARG A 185
GLY A  86
 None
 1.37A 5m50E-2fi1A:
2.3		 5m50E-2fi1A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 4 LEU A 173
GLY A 155
SER A 154
SER A 153
 None
 1.33A 5uunA-2fi1A:
undetectable		 5uunA-2fi1A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 4 LEU A 173
GLY A 155
SER A 154
SER A 153
 None
 1.32A 5uunB-2fi1A:
undetectable		 5uunB-2fi1A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 7 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.46A 5wk9A-2fi1A:
undetectable		 5wk9A-2fi1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 12 VAL A 111
THR A 129
LEU A  83
PHE A 124
LEU A  91
 None
 1.33A 6a93B-2fi1A:
undetectable		 6a93B-2fi1A:
20.29