SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fim'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 2fim TUBBY RELATED
PROTEIN 1
(Homo
sapiens) 		4 / 4 GLN A 348
GLU A 349
ILE A 384
PRO A 383
 None
 1.40A 2fcnA-2fimA:
undetectable		 2fcnA-2fimA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2fim TUBBY RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 275
LEU A 283
LEU A 284
LEU A 350
VAL A 328
 None
 1.01A 2pnjA-2fimA:
undetectable		 2pnjA-2fimA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2fim TUBBY RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 9 PHE A 329
GLY A 315
GLN A 336
ASN A 331
GLY A 332
 None
 1.41A 3kmoA-2fimA:
undetectable		 3kmoA-2fimA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2fim TUBBY RELATED
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 256
ILE A 477
PHE A 475
GLY A 286
 None
 0.86A 4hb6A-2fimA:
undetectable		 4hb6A-2fimA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 2fim TUBBY RELATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 ILE A 372
PRO A 373
ILE A 406
 None
None
3DP  A1003 ( 4.8A)
 0.42A 5hw8F-2fimA:
undetectable		 5hw8F-2fimA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2fim TUBBY RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 430
PHE A 426
GLN A 439
ILE A 477
ALA A 478
 None
 1.04A 5n0sB-2fimA:
undetectable		 5n0sB-2fimA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 2fim TUBBY RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A 480
TYR A 355
LEU A 469
ALA A 478
LEU A 463
 None
 1.10A 5zwrB-2fimA:
undetectable		 5zwrB-2fimA:
24.45