SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fiy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 290
GLY A 294
LEU A 296
TYR A 262
 None
 1.04A 1gtiD-2fiyA:
undetectable		 1gtiD-2fiyA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 290
GLY A 294
LEU A 296
TYR A 262
 None
 1.05A 1gtiE-2fiyA:
undetectable		 1gtiE-2fiyA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 266
ILE A 197
ALA A 276
MET A 193
 None
 1.27A 1hk2A-2fiyA:
undetectable		 1hk2A-2fiyA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 293
LEU A 290
HIS A 233
 None
 0.69A 1qknA-2fiyA:
undetectable		 1qknA-2fiyA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 206
HIS A 219
LYS A  19
 None
 1.10A 1y7iA-2fiyA:
undetectable		 1y7iA-2fiyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 7 ARG A  32
ARG A 198
GLU A 217
SER A 210
 None
 1.22A 2zt7A-2fiyA:
undetectable		 2zt7A-2fiyA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  33
ALA A  30
ASP A 279
ALA A 278
GLN A  38
 None
 1.19A 3id6C-2fiyA:
undetectable		 3id6C-2fiyA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 125
LEU A 140
GLY A 157
ALA A 158
LEU A  55
 None
 1.08A 3n8zB-2fiyA:
undetectable		 3n8zB-2fiyA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 107
TYR A 110
ALA A 121
GLY A 119
LEU A 152
 None
 1.19A 3ou7A-2fiyA:
undetectable		 3ou7A-2fiyA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 107
TYR A 110
ALA A 121
GLY A 119
LEU A 152
 None
 1.22A 3ou7D-2fiyA:
undetectable		 3ou7D-2fiyA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 286
SER A 283
ALA A 282
LEU A 239
 None
 1.06A 3ravA-2fiyA:
undetectable		 3ravA-2fiyA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 286
SER A 283
ALA A 282
LEU A 239
 None
 1.08A 3rd0A-2fiyA:
undetectable		 3rd0A-2fiyA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 266
ASP A 271
ARG A  35
 None
 0.89A 4eahF-2fiyA:
undetectable		 4eahF-2fiyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 266
ASP A 271
ARG A  35
 None
 0.89A 4eahG-2fiyA:
undetectable		 4eahG-2fiyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 302
GLY A 157
GLN A 161
LEU A  55
VAL A 118
 None
 1.42A 4okxA-2fiyA:
undetectable		 4okxA-2fiyA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 125
LEU A 140
GLY A 157
ALA A 158
LEU A  55
 None
 1.11A 4rrxB-2fiyA:
undetectable		 4rrxB-2fiyA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 192
ILE A 138
SER A 226
 None
 0.78A 5fsaA-2fiyA:
undetectable		 5fsaA-2fiyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 6 CYH A 214
CYH A 188
HIS A 166
LEU A 168
 FE  A 401 (-2.3A)
FE  A 401 (-2.3A)
None
None
 1.48A 5hrqH-2fiyA:
undetectable
5hrqK-2fiyA:
undetectable
5hrqL-2fiyA:
undetectable		 5hrqH-2fiyA:
9.02
5hrqK-2fiyA:
6.14
5hrqL-2fiyA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 125
LEU A 140
GLY A 157
ALA A 158
LEU A  55
 None
 1.08A 5ikqA-2fiyA:
undetectable		 5ikqA-2fiyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2fiy PROTEIN FDHE HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 125
LEU A 140
GLY A 157
ALA A 158
LEU A  55
 None
 1.06A 5ikqB-2fiyA:
undetectable		 5ikqB-2fiyA:
20.00