SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fj0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AX9_A_EDRA999_1 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 8	GLY A 146 SER A 226 PHE A 361 HIS A 471	TFC A 600 (-3.4A) TFC A 600 (-1.4A) TFC A 600 (-4.4A) TFC A 600 (-4.2A)	0.74A	1ax9A-2fj0A: 49.2	1ax9A-2fj0A: 29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D4S_A_TPVA201_2 (PROTEIN (HIV-1 PROTEASE))	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 8	LEU A 203 GLY A 215 ILE A 169 PHE A 245	None	0.77A	1d4sB-2fj0A: undetectable	1d4sB-2fj0A: 11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DF7_A_MTXA501_2 (DIHYDROFOLATE REDUCTASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	3 / 3	TRP A 38 ARG A 56 THR A 34	None	0.92A	1df7A-2fj0A: undetectable	1df7A-2fj0A: 15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DX6_A_GNTA602_1 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 12	GLY A 145 GLY A 146 GLY A 147 SER A 226 PHE A 361 HIS A 471	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-4.4A) TFC A 600 (-4.2A)	0.66A	1dx6A-2fj0A: 47.5	1dx6A-2fj0A: 29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FDU_C_ESTC353_1 (17-BETA-HYDROXYSTERO ID DEHYDROGENASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	SER A 184 GLY A 192 PRO A 318 PHE A 182 VAL A 200	None	1.18A	1fduC-2fj0A: undetectable	1fduC-2fj0A: 22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IEP_B_STIB202_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 7	VAL A 518 VAL A 527 ILE A 350 LEU A 532	None	0.94A	1iepB-2fj0A: undetectable	1iepB-2fj0A: 18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IGX_A_EPAA700_1 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 12	PHE A 361 PHE A 259 GLY A 253 ALA A 229 SER A 226 GLY A 146	TFC A 600 (-4.4A) TFC A 600 (-4.0A) None None TFC A 600 (-1.4A) TFC A 600 (-3.4A)	1.50A	1igxA-2fj0A: undetectable	1igxA-2fj0A: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IGX_A_EPAA700_1 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 12	PHE A 361 PHE A 259 GLY A 253 ALA A 229 SER A 226 GLY A 147	TFC A 600 (-4.4A) TFC A 600 (-4.0A) None None TFC A 600 (-1.4A) TFC A 600 (-3.6A)	1.45A	1igxA-2fj0A: undetectable	1igxA-2fj0A: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L5R_A_RBFA859_1 (GLYCOGEN PHOSPHORYLASE, LIVER FORM)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 11	LEU A 98 HIS A 471 ALA A 229 GLY A 224 PHE A 458	None TFC A 600 (-4.2A) None None None	1.20A	1l5rA-2fj0A: 5.4	1l5rA-2fj0A: 20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1MX1_A_THAA1_1 (LIVER CARBOXYLESTERASE I)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 11	LEU A 98 GLY A 146 GLY A 147 SER A 226 HIS A 471	None TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-4.2A)	0.93A	1mx1A-2fj0A: 49.2	1mx1A-2fj0A: 30.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1MX1_D_THAD4_1 (LIVER CARBOXYLESTERASE I)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	GLY A 146 GLY A 147 SER A 226 PHE A 425 HIS A 471	TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) None TFC A 600 (-4.2A)	0.52A	1mx1D-2fj0A: 46.4	1mx1D-2fj0A: 30.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1MX1_D_THAD4_1 (LIVER CARBOXYLESTERASE I)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	LEU A 98 GLY A 146 GLY A 147 SER A 226 HIS A 471	None TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-4.2A)	0.92A	1mx1D-2fj0A: 46.4	1mx1D-2fj0A: 30.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1MX1_F_THAF6_1 (LIVER CARBOXYLESTERASE I)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	GLY A 146 GLY A 147 SER A 226 PHE A 425 HIS A 471	TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) None TFC A 600 (-4.2A)	0.46A	1mx1F-2fj0A: 46.2	1mx1F-2fj0A: 30.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N49_D_RITD401_2 (PROTEASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 6	GLY A 352 ILE A 351 PRO A 517 ILE A 508	None	0.87A	1n49D-2fj0A: undetectable	1n49D-2fj0A: 10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OHR_A_1UNA201_1 (ASPARTYLPROTEASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 11	GLY A 224 GLY A 352 ILE A 351 PRO A 517 ILE A 508	None	0.82A	1ohrA-2fj0A: undetectable	1ohrA-2fj0A: 11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PK2_A_ACAA91_1 (TISSUE-TYPE PLASMINOGEN ACTIVATOR)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 8	TYR A 427 ASP A 560 ASP A 557 LEU A 446	None	1.02A	1pk2A-2fj0A: undetectable	1pk2A-2fj0A: 9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QTI_A_GNTA600_1 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 12	GLY A 145 GLY A 146 GLY A 147 SER A 226 PHE A 361 HIS A 471	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-4.4A) TFC A 600 (-4.2A)	0.68A	1qtiA-2fj0A: 49.1	1qtiA-2fj0A: 29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QTI_A_GNTA600_1 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 12	GLY A 145 GLY A 146 GLY A 147 SER A 226 PHE A 361 HIS A 471	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-4.4A) TFC A 600 (-4.2A)	1.36A	1qtiA-2fj0A: 49.1	1qtiA-2fj0A: 29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SH9_B_RITB301_1 (POL POLYPROTEIN)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 8	ASP A 474 ILE A 508 ILE A 249 GLY A 224 ILE A 143	None	1.42A	1sh9A-2fj0A: 0.3	1sh9A-2fj0A: 10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W6R_A_GNTA1536_1 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 12	GLY A 145 GLY A 146 GLY A 147 SER A 226 PHE A 361 HIS A 471	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-4.4A) TFC A 600 (-4.2A)	0.65A	1w6rA-2fj0A: 47.5	1w6rA-2fj0A: 29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W6R_A_GNTA1536_1 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 12	GLY A 145 GLY A 146 GLY A 147 SER A 226 PHE A 361 HIS A 471	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-4.4A) TFC A 600 (-4.2A)	1.37A	1w6rA-2fj0A: 47.5	1w6rA-2fj0A: 29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W6R_A_GNTA1536_1 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 12	GLY A 224 GLY A 228 PHE A 260 PHE A 148 PHE A 425 PHE A 259	None None None None None TFC A 600 (-4.0A)	1.42A	1w6rA-2fj0A: 47.5	1w6rA-2fj0A: 29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 11	GLY A 146 GLY A 147 SER A 226 PHE A 361 HIS A 471	TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-4.4A) TFC A 600 (-4.2A)	0.68A	1w76A-2fj0A: 49.2	1w76A-2fj0A: 29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W76_B_GNTB1538_1 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 10	GLY A 145 GLY A 146 SER A 226 PHE A 361 HIS A 471	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-1.4A) TFC A 600 (-4.4A) TFC A 600 (-4.2A)	0.62A	1w76B-2fj0A: 49.2	1w76B-2fj0A: 29.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1YAJ_C_BEZC5013_0 (CES1 PROTEIN)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 8	GLY A 145 GLY A 146 GLY A 147 ALA A 227 LEU A 313	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-3.5A) TFC A 600 (-4.2A)	0.77A	1yajC-2fj0A: 45.6	1yajC-2fj0A: 30.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1YAJ_C_BEZC5013_0 (CES1 PROTEIN)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 8	GLY A 145 GLY A 146 GLY A 147 SER A 226 ALA A 227 HIS A 471	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-3.5A) TFC A 600 (-4.2A)	0.56A	1yajC-2fj0A: 45.6	1yajC-2fj0A: 30.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1YAJ_C_BEZC5013_0 (CES1 PROTEIN)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 8	GLY A 228 GLY A 145 GLY A 146 SER A 226 ALA A 227 HIS A 471	None TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-1.4A) TFC A 600 (-3.5A) TFC A 600 (-4.2A)	1.15A	1yajC-2fj0A: 45.6	1yajC-2fj0A: 30.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YKI_A_NFZA1219_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 8	PHE A 451 GLU A 359 GLY A 470 PHE A 466	None	1.00A	1ykiA-2fj0A: undetectable 1ykiB-2fj0A: undetectable	1ykiA-2fj0A: 18.11 1ykiB-2fj0A: 18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YKI_B_NFZB2219_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 8	PHE A 466 PHE A 451 GLU A 359 GLY A 470	None	1.01A	1ykiA-2fj0A: undetectable 1ykiB-2fj0A: undetectable	1ykiA-2fj0A: 18.11 1ykiB-2fj0A: 18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YKI_C_NFZC3219_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 8	PHE A 451 GLU A 359 GLY A 470 PHE A 466	None	1.01A	1ykiC-2fj0A: undetectable 1ykiD-2fj0A: undetectable	1ykiC-2fj0A: 18.11 1ykiD-2fj0A: 18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YKI_D_NFZD4219_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 8	PHE A 466 PHE A 451 GLU A 359 GLY A 470	None	0.99A	1ykiC-2fj0A: undetectable 1ykiD-2fj0A: undetectable	1ykiC-2fj0A: 18.11 1ykiD-2fj0A: 18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACE_A_ACHA998_0 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 9	GLY A 145 GLY A 146 SER A 226 ALA A 227 HIS A 471	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-1.4A) TFC A 600 (-3.5A) TFC A 600 (-4.2A)	0.94A	2aceA-2fj0A: 49.1	2aceA-2fj0A: 29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACE_A_ACHA998_0 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 9	GLY A 145 GLY A 146 SER A 226 ALA A 227 PHE A 150 PHE A 458	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-1.4A) TFC A 600 (-3.5A) None None	1.08A	2aceA-2fj0A: 49.1	2aceA-2fj0A: 29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACE_A_ACHA998_0 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 9	GLY A 146 GLY A 147 SER A 226 ALA A 227 HIS A 471	TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-3.5A) TFC A 600 (-4.2A)	0.70A	2aceA-2fj0A: 49.1	2aceA-2fj0A: 29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACK_A_EDRA999_1 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 7	GLY A 146 SER A 226 PHE A 361 HIS A 471	TFC A 600 (-3.4A) TFC A 600 (-1.4A) TFC A 600 (-4.4A) TFC A 600 (-4.2A)	0.79A	2ackA-2fj0A: 13.7	2ackA-2fj0A: 29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AQU_B_DR7B300_1 (HIV-1 PROTEASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 10	GLY A 224 GLY A 352 ILE A 351 PRO A 517 ILE A 508	None	0.95A	2aquA-2fj0A: undetectable	2aquA-2fj0A: 11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EGV_A_SAMA1300_0 (UPF0088 PROTEIN AQ_165)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	ASN A 174 VAL A 58 GLY A 57 GLY A 89 LEU A 202	None	1.05A	2egvA-2fj0A: undetectable	2egvA-2fj0A: 19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EGV_B_SAMB1400_0 (UPF0088 PROTEIN AQ_165)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	ASN A 174 VAL A 58 GLY A 57 GLY A 89 LEU A 202	None	1.03A	2egvB-2fj0A: undetectable	2egvB-2fj0A: 19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2HA4_A_ACTA544_0 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 8	GLY A 146 GLY A 147 ALA A 227 HIS A 471	TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-3.5A) TFC A 600 (-4.2A)	0.30A	2ha4A-2fj0A: 46.5	2ha4A-2fj0A: 31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2HA4_B_ACTB601_0 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 7	GLY A 146 GLY A 147 ALA A 227 HIS A 471	TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-3.5A) TFC A 600 (-4.2A)	0.29A	2ha4B-2fj0A: 47.8	2ha4B-2fj0A: 31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JFA_B_RALB600_2 (ESTROGEN RECEPTOR)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 4	LEU A 313 THR A 314 ILE A 472 HIS A 471	TFC A 600 (-4.2A) TFC A 600 ( 4.6A) None TFC A 600 (-4.2A)	1.26A	2jfaB-2fj0A: undetectable	2jfaB-2fj0A: 19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NPN_A_SAMA4633_0 (PUTATIVE COBALAMIN SYNTHESIS RELATED PROTEIN)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 9	GLY A 224 LEU A 222 THR A 232 ALA A 231 LEU A 202	None	1.15A	2npnA-2fj0A: 2.6	2npnA-2fj0A: 17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PIW_A_T3A933_1 (ANDROGEN RECEPTOR)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 10	ILE A 169 GLY A 159 ASN A 482 GLU A 88 ASN A 116	None	1.40A	2piwA-2fj0A: 0.0	2piwA-2fj0A: 18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TOD_C_DMOC700_1 (PROTEIN (ORNITHINE DECARBOXYLASE))	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 5	ASP A 355 PHE A 353 ASP A 536 TYR A 534	None	1.40A	2todC-2fj0A: 1.5 2todD-2fj0A: 1.4	2todC-2fj0A: 22.63 2todD-2fj0A: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCV_A_ASDA1224_1 (GLUTATHIONE S-TRANSFERASE A3)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 7	PHE A 316 ALA A 303 LEU A 300 PHE A 70	None	0.87A	2vcvA-2fj0A: undetectable	2vcvA-2fj0A: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCV_F_ASDF1224_1 (GLUTATHIONE S-TRANSFERASE A3)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 8	PHE A 316 ALA A 303 LEU A 300 PHE A 70	None	0.84A	2vcvF-2fj0A: undetectable	2vcvF-2fj0A: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCV_P_ASDP1224_1 (GLUTATHIONE S-TRANSFERASE A3)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 8	PHE A 316 ALA A 303 LEU A 300 PHE A 70	None	0.59A	2vcvP-2fj0A: undetectable	2vcvP-2fj0A: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y6R_B_CTCB1385_0 (TETX2 PROTEIN)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 8	MET A 426 PHE A 353 GLY A 352 GLY A 468	None	0.89A	2y6rB-2fj0A: undetectable	2y6rB-2fj0A: 23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AQI_A_CHDA3_0 (FERROCHELATASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	3 / 3	PRO A 64 LEU A 73 ARG A 197	None	0.81A	3aqiA-2fj0A: 2.8	3aqiA-2fj0A: 20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ARU_A_PNXA607_1 (CHITINASE A)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 8	VAL A 327 GLY A 192 PHE A 182 GLY A 195 ALA A 194	None	1.43A	3aruA-2fj0A: 2.3	3aruA-2fj0A: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EKX_B_1UNB201_1 (PROTEASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 11	GLY A 224 GLY A 352 ILE A 351 PRO A 517 ILE A 508	None	0.94A	3ekxA-2fj0A: undetectable	3ekxA-2fj0A: 10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EKY_A_DR7A100_1 (PROTEASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 10	GLY A 224 GLY A 352 ILE A 351 PRO A 517 ILE A 508	None	0.97A	3ekyA-2fj0A: undetectable	3ekyA-2fj0A: 10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ITA_D_AICD501_1 (D-ALANYL-D-ALANINE CARBOXYPEPTIDASE DACC)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	3 / 3	PRO A 318 PHE A 259 ALA A 230	None TFC A 600 (-4.0A) None	0.73A	3itaD-2fj0A: undetectable	3itaD-2fj0A: 22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IV6_A_SAMA301_0 (PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	PHE A 173 GLY A 195 PHE A 148 THR A 262 LEU A 196	None	1.25A	3iv6A-2fj0A: undetectable	3iv6A-2fj0A: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IV6_B_SAMB301_0 (PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	PHE A 425 GLY A 352 SER A 252 ASP A 536 ILE A 537	None	1.32A	3iv6B-2fj0A: undetectable	3iv6B-2fj0A: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LSL_D_PZID801_0 (GLUTAMATE RECEPTOR 2)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 8	ASN A 271 ILE A 288 PRO A 285 SER A 187 SER A 184	None	1.47A	3lslA-2fj0A: undetectable 3lslD-2fj0A: undetectable	3lslA-2fj0A: 18.92 3lslD-2fj0A: 18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O9M_A_BEZA999_0 (CHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 7	GLY A 145 GLY A 146 SER A 226 LEU A 313 HIS A 471	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-1.4A) TFC A 600 (-4.2A) TFC A 600 (-4.2A)	1.05A	3o9mA-2fj0A: 49.9	3o9mA-2fj0A: 28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O9M_A_BEZA999_0 (CHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 7	GLY A 146 GLY A 147 SER A 226 PHE A 425 HIS A 471	TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) None TFC A 600 (-4.2A)	0.75A	3o9mA-2fj0A: 49.9	3o9mA-2fj0A: 28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O9M_B_BEZB999_0 (CHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 6	GLY A 145 GLY A 146 SER A 226 LEU A 313 HIS A 471	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-1.4A) TFC A 600 (-4.2A) TFC A 600 (-4.2A)	1.09A	3o9mB-2fj0A: 49.8	3o9mB-2fj0A: 28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O9M_B_BEZB999_0 (CHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 6	GLY A 146 GLY A 147 SER A 226 HIS A 471	TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-4.2A)	0.80A	3o9mB-2fj0A: 49.8	3o9mB-2fj0A: 28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QXY_A_SAMA6734_0 (N-LYSINE METHYLTRANSFERASE SETD6)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	ALA A 194 GLY A 195 TYR A 175 ALA A 61 TYR A 60	None	1.16A	3qxyA-2fj0A: undetectable	3qxyA-2fj0A: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QXY_B_SAMB6735_0 (N-LYSINE METHYLTRANSFERASE SETD6 TRANSCRIPTION FACTOR P65)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 11	ALA A 194 GLY A 195 TYR A 175 ALA A 61 TYR A 60	None	1.14A	3qxyB-2fj0A: undetectable 3qxyQ-2fj0A: undetectable	3qxyB-2fj0A: 21.82 3qxyQ-2fj0A: 2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RC0_A_SAMA484_0 (N-LYSINE METHYLTRANSFERASE SETD6)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 11	ALA A 194 GLY A 195 TYR A 175 ALA A 61 TYR A 60	None	1.13A	3rc0A-2fj0A: undetectable	3rc0A-2fj0A: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RC0_B_SAMB480_0 (N-LYSINE METHYLTRANSFERASE SETD6)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	ALA A 194 GLY A 195 TYR A 175 ALA A 61 TYR A 60	None	1.12A	3rc0B-2fj0A: undetectable	3rc0B-2fj0A: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_S_CLMS221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	PHE A 173 THR A 232 LEU A 140 VAL A 170 PHE A 479	None	1.29A	3u9fP-2fj0A: undetectable 3u9fS-2fj0A: undetectable	3u9fP-2fj0A: 15.08 3u9fS-2fj0A: 15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UT5_D_LOCD502_1 (TUBULIN BETA CHAIN)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	LEU A 185 LEU A 292 MET A 295 ALA A 282 ILE A 278	None	0.96A	3ut5D-2fj0A: 2.9	3ut5D-2fj0A: 22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DJF_B_C2FB300_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	PHE A 458 ILE A 508 LEU A 140 GLY A 224 SER A 226	None None None None TFC A 600 (-1.4A)	1.31A	4djfB-2fj0A: undetectable	4djfB-2fj0A: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EY6_A_GNTA604_1 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 12	GLY A 145 GLY A 146 GLY A 147 SER A 226 PHE A 361 HIS A 471	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-4.4A) TFC A 600 (-4.2A)	0.64A	4ey6A-2fj0A: 48.2	4ey6A-2fj0A: 29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EY6_A_GNTA604_1 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 12	GLY A 145 GLY A 146 GLY A 147 SER A 226 PHE A 361 HIS A 471	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-4.4A) TFC A 600 (-4.2A)	1.44A	4ey6A-2fj0A: 48.2	4ey6A-2fj0A: 29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EY6_B_GNTB605_1 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 12	GLY A 145 GLY A 146 GLY A 147 SER A 226 PHE A 361 HIS A 471	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-4.4A) TFC A 600 (-4.2A)	0.64A	4ey6B-2fj0A: 42.4	4ey6B-2fj0A: 29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EY6_B_GNTB605_1 (ACETYLCHOLINESTERASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	6 / 12	GLY A 145 GLY A 146 GLY A 147 SER A 226 PHE A 361 HIS A 471	TFC A 600 (-3.5A) TFC A 600 (-3.4A) TFC A 600 (-3.6A) TFC A 600 (-1.4A) TFC A 600 (-4.4A) TFC A 600 (-4.2A)	1.44A	4ey6B-2fj0A: 42.4	4ey6B-2fj0A: 29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NJV_A_RITA500_2 (PROTEASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 11	GLY A 224 GLY A 352 ILE A 351 PRO A 517 ILE A 508	None	0.91A	4njvB-2fj0A: undetectable	4njvB-2fj0A: 10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NJV_D_RITD500_1 (PROTEASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 11	GLY A 224 GLY A 352 ILE A 351 PRO A 517 ILE A 508	None	0.96A	4njvC-2fj0A: undetectable	4njvC-2fj0A: 10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PFJ_B_ADNB502_1 (ADENOSYLHOMOCYSTEINA SE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	HIS A 233 THR A 232 LEU A 432 LEU A 250 PHE A 245	None	1.34A	4pfjB-2fj0A: undetectable	4pfjB-2fj0A: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	3 / 3	GLU A 161 THR A 172 HIS A 118	None	0.83A	4q15A-2fj0A: undetectable	4q15A-2fj0A: 20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	3 / 3	GLU A 161 THR A 172 HIS A 118	None	0.84A	4q15B-2fj0A: undetectable	4q15B-2fj0A: 20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QCK_A_ASDA404_1 (3-KETOSTEROID-9-ALPH A-MONOOXYGENASE OXYGENASE SUBUNIT)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	VAL A 91 GLN A 94 LEU A 308 MET A 103 LEU A 98	None	1.33A	4qckA-2fj0A: undetectable	4qckA-2fj0A: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1I_D_LOCD502_1 (TUBULIN BETA CHAIN)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	LEU A 185 LEU A 292 MET A 295 ALA A 282 ILE A 278	None	0.95A	4x1iD-2fj0A: 2.6	4x1iD-2fj0A: 22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1Y_D_LOCD502_2 (TUBULIN BETA CHAIN)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	LEU A 185 LEU A 292 MET A 295 ALA A 282 ILE A 278	None	0.96A	4x1yD-2fj0A: 2.6	4x1yD-2fj0A: 22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	3 / 3	GLU A 161 THR A 172 HIS A 118	None	0.75A	4ydqB-2fj0A: undetectable	4ydqB-2fj0A: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DLV_A_5D5A930_1 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 6	SER A 423 TYR A 427 PHE A 559 TRP A 565	None	1.33A	5dlvA-2fj0A: 1.4	5dlvA-2fj0A: 22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_R_BEZR801_1 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 8	SER A 226 ALA A 227 HIS A 471 LEU A 313	TFC A 600 (-1.4A) TFC A 600 (-3.5A) TFC A 600 (-4.2A) TFC A 600 (-4.2A)	0.99A	5dzkd-2fj0A: 2.4 5dzkr-2fj0A: undetectable	5dzkd-2fj0A: 17.60 5dzkr-2fj0A: 1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_T_BEZT801_1 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 8	SER A 226 ALA A 227 HIS A 471 LEU A 313	TFC A 600 (-1.4A) TFC A 600 (-3.5A) TFC A 600 (-4.2A) TFC A 600 (-4.2A)	1.09A	5dzkF-2fj0A: 2.5 5dzkT-2fj0A: undetectable	5dzkF-2fj0A: 17.60 5dzkT-2fj0A: 1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_U_BEZU801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 6	PHE A 260 SER A 226 ALA A 227 HIS A 471	None TFC A 600 (-1.4A) TFC A 600 (-3.5A) TFC A 600 (-4.2A)	1.28A	5dzkg-2fj0A: 2.5 5dzku-2fj0A: undetectable	5dzkg-2fj0A: 17.60 5dzku-2fj0A: 1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EML_A_SAMA701_1 (PROTEIN ARGININE N-METHYLTRANSFERASE 5)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 6	TYR A 477 TYR A 447 GLY A 470 GLU A 473	None	1.34A	5emlA-2fj0A: undetectable	5emlA-2fj0A: 23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FHZ_A_REAA602_1 (ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	GLY A 379 THR A 399 ASN A 263 PHE A 388 LEU A 387	None	1.22A	5fhzA-2fj0A: undetectable	5fhzA-2fj0A: 22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IQE_C_NMYC600_1 (BIFUNCTIONAL AAC/APH)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	ASP A 560 ASP A 557 TYR A 427 SER A 256 GLU A 336	None	1.49A	5iqeC-2fj0A: 0.1	5iqeC-2fj0A: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KBW_B_RBFB201_1 (RIBOFLAVIN TRANSPORTER RIBU)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	LEU A 183 ASP A 198 GLY A 195 ASN A 193 ASN A 271	None	1.39A	5kbwB-2fj0A: undetectable	5kbwB-2fj0A: 16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NM5_B_LOCB502_2 (TUBULIN BETA-2B CHAIN)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	LEU A 185 LEU A 292 MET A 295 ALA A 282 ILE A 278	None	0.96A	5nm5B-2fj0A: 3.0	5nm5B-2fj0A: 22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_A_ACTA307_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 4	LEU A 331 LEU A 196 SER A 255 ALA A 231	None	1.13A	5uunA-2fj0A: undetectable	5uunA-2fj0A: 18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BXM_A_SAMA402_0 (DIPHTHAMIDE BIOSYNTHESIS ENZYME DPH2)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 12	LEU A 137 GLY A 136 LEU A 203 ARG A 216 ASP A 218	None	1.06A	6bxmA-2fj0A: undetectable	6bxmA-2fj0A: 21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C71_B_NCTB501_1 (AMINE OXIDASE)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	4 / 8	LEU A 163 GLU A 161 THR A 505 ASN A 482	None	1.08A	6c71B-2fj0A: undetectable	6c71B-2fj0A: 8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWN_C_AQ4C602_1 (CYTOCHROME P450 1A1)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	3 / 3	SER A 255 SER A 256 ALA A 340	None	0.63A	6dwnC-2fj0A: undetectable	6dwnC-2fj0A: 10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EFN_A_SAMA501_0 (SPORULATION KILLING FACTOR MATURATION PROTEIN SKFB)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	5 / 11	GLU A 357 PHE A 259 SER A 226 ALA A 227 LEU A 308	None TFC A 600 (-4.0A) TFC A 600 (-1.4A) TFC A 600 (-3.5A) None	1.36A	6efnA-2fj0A: 2.2	6efnA-2fj0A: 22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NKN_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2fj0	CARBOXYLIC ESTER HYDROLASE (Manduca sexta)	3 / 3	ARG A 362 PHE A 458 PHE A 365	None None TFC A 600 ( 4.9A)	1.06A	6nknC-2fj0A: undetectable 6nknJ-2fj0A: undetectable	6nknC-2fj0A: 18.71 6nknJ-2fj0A: 8.17

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AX9_A_EDRA999_1","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"GLY A 146;SER A 226;PHE A 361;HIS A 471","TFC A 600 (-3.4A);TFC A 600 (-1.4A);TFC A 600 (-4.4A);TFC A 600 (-4.2A)","0.74A","1ax9A-2fj0A:49.2","1ax9A-2fj0A:29.29"],["1D4S_A_TPVA201_2","PROTEIN (HIV-1 PROTEASE);PROTEIN (HIV-1 PROTEASE)","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"LEU A 203;GLY A 215;ILE A 169;PHE A 245","None","0.77A","1d4sB-2fj0A:undetectable","1d4sB-2fj0A:11.52"],["1DF7_A_MTXA501_2","DIHYDROFOLATE REDUCTASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",3,"TRP A  38;ARG A  56;THR A  34","None","0.92A","1df7A-2fj0A:undetectable","1df7A-2fj0A:15.34"],["1DX6_A_GNTA602_1","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"GLY A 145;GLY A 146;GLY A 147;SER A 226;PHE A 361;HIS A 471","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-4.4A);TFC A 600 (-4.2A)","0.66A","1dx6A-2fj0A:47.5","1dx6A-2fj0A:29.65"],["1FDU_C_ESTC353_1","17-BETA-HYDROXYSTEROID DEHYDROGENASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"SER A 184;GLY A 192;PRO A 318;PHE A 182;VAL A 200","None","1.18A","1fduC-2fj0A:undetectable","1fduC-2fj0A:22.72"],["1IEP_B_STIB202_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"VAL A 518;VAL A 527;ILE A 350;LEU A 532","None","0.94A","1iepB-2fj0A:undetectable","1iepB-2fj0A:18.33"],["1IGX_A_EPAA700_1","PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"PHE A 361;PHE A 259;GLY A 253;ALA A 229;SER A 226;GLY A 146","TFC A 600 (-4.4A);TFC A 600 (-4.0A);None;None;TFC A 600 (-1.4A);TFC A 600 (-3.4A)","1.50A","1igxA-2fj0A:undetectable","1igxA-2fj0A:21.34"],["1IGX_A_EPAA700_1","PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"PHE A 361;PHE A 259;GLY A 253;ALA A 229;SER A 226;GLY A 147","TFC A 600 (-4.4A);TFC A 600 (-4.0A);None;None;TFC A 600 (-1.4A);TFC A 600 (-3.6A)","1.45A","1igxA-2fj0A:undetectable","1igxA-2fj0A:21.34"],["1L5R_A_RBFA859_1","GLYCOGEN PHOSPHORYLASE, LIVER FORM","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"LEU A  98;HIS A 471;ALA A 229;GLY A 224;PHE A 458","None;TFC A 600 (-4.2A);None;None;None","1.20A","1l5rA-2fj0A:5.4","1l5rA-2fj0A:20.05"],["1MX1_A_THAA1_1","LIVER CARBOXYLESTERASE I","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"LEU A  98;GLY A 146;GLY A 147;SER A 226;HIS A 471","None;TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-4.2A)","0.93A","1mx1A-2fj0A:49.2","1mx1A-2fj0A:30.41"],["1MX1_D_THAD4_1","LIVER CARBOXYLESTERASE I","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 146;GLY A 147;SER A 226;PHE A 425;HIS A 471","TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);None;TFC A 600 (-4.2A)","0.52A","1mx1D-2fj0A:46.4","1mx1D-2fj0A:30.41"],["1MX1_D_THAD4_1","LIVER CARBOXYLESTERASE I","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"LEU A  98;GLY A 146;GLY A 147;SER A 226;HIS A 471","None;TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-4.2A)","0.92A","1mx1D-2fj0A:46.4","1mx1D-2fj0A:30.41"],["1MX1_F_THAF6_1","LIVER CARBOXYLESTERASE I","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 146;GLY A 147;SER A 226;PHE A 425;HIS A 471","TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);None;TFC A 600 (-4.2A)","0.46A","1mx1F-2fj0A:46.2","1mx1F-2fj0A:30.41"],["1N49_D_RITD401_2","PROTEASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"GLY A 352;ILE A 351;PRO A 517;ILE A 508","None","0.87A","1n49D-2fj0A:undetectable","1n49D-2fj0A:10.67"],["1OHR_A_1UNA201_1","ASPARTYLPROTEASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 224;GLY A 352;ILE A 351;PRO A 517;ILE A 508","None","0.82A","1ohrA-2fj0A:undetectable","1ohrA-2fj0A:11.52"],["1PK2_A_ACAA91_1","TISSUE-TYPE PLASMINOGEN ACTIVATOR","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"TYR A 427;ASP A 560;ASP A 557;LEU A 446","None","1.02A","1pk2A-2fj0A:undetectable","1pk2A-2fj0A:9.31"],["1QTI_A_GNTA600_1","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"GLY A 145;GLY A 146;GLY A 147;SER A 226;PHE A 361;HIS A 471","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-4.4A);TFC A 600 (-4.2A)","0.68A","1qtiA-2fj0A:49.1","1qtiA-2fj0A:29.29"],["1QTI_A_GNTA600_1","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"GLY A 145;GLY A 146;GLY A 147;SER A 226;PHE A 361;HIS A 471","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-4.4A);TFC A 600 (-4.2A)","1.36A","1qtiA-2fj0A:49.1","1qtiA-2fj0A:29.29"],["1SH9_B_RITB301_1","POL POLYPROTEIN;POL POLYPROTEIN","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"ASP A 474;ILE A 508;ILE A 249;GLY A 224;ILE A 143","None","1.42A","1sh9A-2fj0A:0.3","1sh9A-2fj0A:10.91"],["1W6R_A_GNTA1536_1","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"GLY A 145;GLY A 146;GLY A 147;SER A 226;PHE A 361;HIS A 471","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-4.4A);TFC A 600 (-4.2A)","0.65A","1w6rA-2fj0A:47.5","1w6rA-2fj0A:29.65"],["1W6R_A_GNTA1536_1","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"GLY A 145;GLY A 146;GLY A 147;SER A 226;PHE A 361;HIS A 471","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-4.4A);TFC A 600 (-4.2A)","1.37A","1w6rA-2fj0A:47.5","1w6rA-2fj0A:29.65"],["1W6R_A_GNTA1536_1","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"GLY A 224;GLY A 228;PHE A 260;PHE A 148;PHE A 425;PHE A 259","None;None;None;None;None;TFC A 600 (-4.0A)","1.42A","1w6rA-2fj0A:47.5","1w6rA-2fj0A:29.65"],["1W76_A_GNTA1538_1","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 146;GLY A 147;SER A 226;PHE A 361;HIS A 471","TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-4.4A);TFC A 600 (-4.2A)","0.68A","1w76A-2fj0A:49.2","1w76A-2fj0A:29.65"],["1W76_B_GNTB1538_1","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 145;GLY A 146;SER A 226;PHE A 361;HIS A 471","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-1.4A);TFC A 600 (-4.4A);TFC A 600 (-4.2A)","0.62A","1w76B-2fj0A:49.2","1w76B-2fj0A:29.65"],["1YAJ_C_BEZC5013_0","CES1 PROTEIN","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 145;GLY A 146;GLY A 147;ALA A 227;LEU A 313","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-3.5A);TFC A 600 (-4.2A)","0.77A","1yajC-2fj0A:45.6","1yajC-2fj0A:30.76"],["1YAJ_C_BEZC5013_0","CES1 PROTEIN","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"GLY A 145;GLY A 146;GLY A 147;SER A 226;ALA A 227;HIS A 471","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-3.5A);TFC A 600 (-4.2A)","0.56A","1yajC-2fj0A:45.6","1yajC-2fj0A:30.76"],["1YAJ_C_BEZC5013_0","CES1 PROTEIN","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"GLY A 228;GLY A 145;GLY A 146;SER A 226;ALA A 227;HIS A 471","None;TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-1.4A);TFC A 600 (-3.5A);TFC A 600 (-4.2A)","1.15A","1yajC-2fj0A:45.6","1yajC-2fj0A:30.76"],["1YKI_A_NFZA1219_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"PHE A 451;GLU A 359;GLY A 470;PHE A 466","None","1.00A","1ykiA-2fj0A:undetectable;1ykiB-2fj0A:undetectable","1ykiA-2fj0A:18.11;1ykiB-2fj0A:18.11"],["1YKI_B_NFZB2219_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"PHE A 466;PHE A 451;GLU A 359;GLY A 470","None","1.01A","1ykiA-2fj0A:undetectable;1ykiB-2fj0A:undetectable","1ykiA-2fj0A:18.11;1ykiB-2fj0A:18.11"],["1YKI_C_NFZC3219_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"PHE A 451;GLU A 359;GLY A 470;PHE A 466","None","1.01A","1ykiC-2fj0A:undetectable;1ykiD-2fj0A:undetectable","1ykiC-2fj0A:18.11;1ykiD-2fj0A:18.11"],["1YKI_D_NFZD4219_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"PHE A 466;PHE A 451;GLU A 359;GLY A 470","None","0.99A","1ykiC-2fj0A:undetectable;1ykiD-2fj0A:undetectable","1ykiC-2fj0A:18.11;1ykiD-2fj0A:18.11"],["2ACE_A_ACHA998_0","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 145;GLY A 146;SER A 226;ALA A 227;HIS A 471","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-1.4A);TFC A 600 (-3.5A);TFC A 600 (-4.2A)","0.94A","2aceA-2fj0A:49.1","2aceA-2fj0A:29.29"],["2ACE_A_ACHA998_0","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"GLY A 145;GLY A 146;SER A 226;ALA A 227;PHE A 150;PHE A 458","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-1.4A);TFC A 600 (-3.5A);None;None","1.08A","2aceA-2fj0A:49.1","2aceA-2fj0A:29.29"],["2ACE_A_ACHA998_0","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 146;GLY A 147;SER A 226;ALA A 227;HIS A 471","TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-3.5A);TFC A 600 (-4.2A)","0.70A","2aceA-2fj0A:49.1","2aceA-2fj0A:29.29"],["2ACK_A_EDRA999_1","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"GLY A 146;SER A 226;PHE A 361;HIS A 471","TFC A 600 (-3.4A);TFC A 600 (-1.4A);TFC A 600 (-4.4A);TFC A 600 (-4.2A)","0.79A","2ackA-2fj0A:13.7","2ackA-2fj0A:29.29"],["2AQU_B_DR7B300_1","HIV-1 PROTEASE;HIV-1 PROTEASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 224;GLY A 352;ILE A 351;PRO A 517;ILE A 508","None","0.95A","2aquA-2fj0A:undetectable","2aquA-2fj0A:11.52"],["2EGV_A_SAMA1300_0","UPF0088 PROTEIN AQ_165","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"ASN A 174;VAL A  58;GLY A  57;GLY A  89;LEU A 202","None","1.05A","2egvA-2fj0A:undetectable","2egvA-2fj0A:19.02"],["2EGV_B_SAMB1400_0","UPF0088 PROTEIN AQ_165","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"ASN A 174;VAL A  58;GLY A  57;GLY A  89;LEU A 202","None","1.03A","2egvB-2fj0A:undetectable","2egvB-2fj0A:19.02"],["2HA4_A_ACTA544_0","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"GLY A 146;GLY A 147;ALA A 227;HIS A 471","TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-3.5A);TFC A 600 (-4.2A)","0.30A","2ha4A-2fj0A:46.5","2ha4A-2fj0A:31.40"],["2HA4_B_ACTB601_0","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"GLY A 146;GLY A 147;ALA A 227;HIS A 471","TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-3.5A);TFC A 600 (-4.2A)","0.29A","2ha4B-2fj0A:47.8","2ha4B-2fj0A:31.40"],["2JFA_B_RALB600_2","ESTROGEN RECEPTOR","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"LEU A 313;THR A 314;ILE A 472;HIS A 471","TFC A 600 (-4.2A);TFC A 600 ( 4.6A);None;TFC A 600 (-4.2A)","1.26A","2jfaB-2fj0A:undetectable","2jfaB-2fj0A:19.27"],["2NPN_A_SAMA4633_0","PUTATIVE COBALAMIN SYNTHESIS RELATED PROTEIN","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 224;LEU A 222;THR A 232;ALA A 231;LEU A 202","None","1.15A","2npnA-2fj0A:2.6","2npnA-2fj0A:17.32"],["2PIW_A_T3A933_1","ANDROGEN RECEPTOR","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"ILE A 169;GLY A 159;ASN A 482;GLU A  88;ASN A 116","None","1.40A","2piwA-2fj0A:0.0","2piwA-2fj0A:18.18"],["2TOD_C_DMOC700_1","PROTEIN (ORNITHINE DECARBOXYLASE);PROTEIN (ORNITHINE DECARBOXYLASE)","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"ASP A 355;PHE A 353;ASP A 536;TYR A 534","None","1.40A","2todC-2fj0A:1.5;2todD-2fj0A:1.4","2todC-2fj0A:22.63;2todD-2fj0A:22.63"],["2VCV_A_ASDA1224_1","GLUTATHIONE S-TRANSFERASE A3","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"PHE A 316;ALA A 303;LEU A 300;PHE A  70","None","0.87A","2vcvA-2fj0A:undetectable","2vcvA-2fj0A:19.00"],["2VCV_F_ASDF1224_1","GLUTATHIONE S-TRANSFERASE A3","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"PHE A 316;ALA A 303;LEU A 300;PHE A  70","None","0.84A","2vcvF-2fj0A:undetectable","2vcvF-2fj0A:19.00"],["2VCV_P_ASDP1224_1","GLUTATHIONE S-TRANSFERASE A3","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"PHE A 316;ALA A 303;LEU A 300;PHE A  70","None","0.59A","2vcvP-2fj0A:undetectable","2vcvP-2fj0A:19.00"],["2Y6R_B_CTCB1385_0","TETX2 PROTEIN","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"MET A 426;PHE A 353;GLY A 352;GLY A 468","None","0.89A","2y6rB-2fj0A:undetectable","2y6rB-2fj0A:23.39"],["3AQI_A_CHDA3_0","FERROCHELATASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",3,"PRO A  64;LEU A  73;ARG A 197","None","0.81A","3aqiA-2fj0A:2.8","3aqiA-2fj0A:20.89"],["3ARU_A_PNXA607_1","CHITINASE A","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"VAL A 327;GLY A 192;PHE A 182;GLY A 195;ALA A 194","None","1.43A","3aruA-2fj0A:2.3","3aruA-2fj0A:21.36"],["3EKX_B_1UNB201_1","PROTEASE;PROTEASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 224;GLY A 352;ILE A 351;PRO A 517;ILE A 508","None","0.94A","3ekxA-2fj0A:undetectable","3ekxA-2fj0A:10.67"],["3EKY_A_DR7A100_1","PROTEASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 224;GLY A 352;ILE A 351;PRO A 517;ILE A 508","None","0.97A","3ekyA-2fj0A:undetectable","3ekyA-2fj0A:10.67"],["3ITA_D_AICD501_1","D-ALANYL-D-ALANINE CARBOXYPEPTIDASE DACC","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",3,"PRO A 318;PHE A 259;ALA A 230","None;TFC A 600 (-4.0A);None","0.73A","3itaD-2fj0A:undetectable","3itaD-2fj0A:22.71"],["3IV6_A_SAMA301_0","PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"PHE A 173;GLY A 195;PHE A 148;THR A 262;LEU A 196","None","1.25A","3iv6A-2fj0A:undetectable","3iv6A-2fj0A:20.29"],["3IV6_B_SAMB301_0","PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"PHE A 425;GLY A 352;SER A 252;ASP A 536;ILE A 537","None","1.32A","3iv6B-2fj0A:undetectable","3iv6B-2fj0A:20.29"],["3LSL_D_PZID801_0","GLUTAMATE RECEPTOR 2","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"ASN A 271;ILE A 288;PRO A 285;SER A 187;SER A 184","None","1.47A","3lslA-2fj0A:undetectable;3lslD-2fj0A:undetectable","3lslA-2fj0A:18.92;3lslD-2fj0A:18.92"],["3O9M_A_BEZA999_0","CHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 145;GLY A 146;SER A 226;LEU A 313;HIS A 471","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-1.4A);TFC A 600 (-4.2A);TFC A 600 (-4.2A)","1.05A","3o9mA-2fj0A:49.9","3o9mA-2fj0A:28.80"],["3O9M_A_BEZA999_0","CHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 146;GLY A 147;SER A 226;PHE A 425;HIS A 471","TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);None;TFC A 600 (-4.2A)","0.75A","3o9mA-2fj0A:49.9","3o9mA-2fj0A:28.80"],["3O9M_B_BEZB999_0","CHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 145;GLY A 146;SER A 226;LEU A 313;HIS A 471","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-1.4A);TFC A 600 (-4.2A);TFC A 600 (-4.2A)","1.09A","3o9mB-2fj0A:49.8","3o9mB-2fj0A:28.80"],["3O9M_B_BEZB999_0","CHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"GLY A 146;GLY A 147;SER A 226;HIS A 471","TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-4.2A)","0.80A","3o9mB-2fj0A:49.8","3o9mB-2fj0A:28.80"],["3QXY_A_SAMA6734_0","N-LYSINE METHYLTRANSFERASE SETD6","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"ALA A 194;GLY A 195;TYR A 175;ALA A  61;TYR A  60","None","1.16A","3qxyA-2fj0A:undetectable","3qxyA-2fj0A:21.82"],["3QXY_B_SAMB6735_0","N-LYSINE METHYLTRANSFERASE SETD6;TRANSCRIPTION FACTOR P65","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"ALA A 194;GLY A 195;TYR A 175;ALA A  61;TYR A  60","None","1.14A","3qxyB-2fj0A:undetectable;3qxyQ-2fj0A:undetectable","3qxyB-2fj0A:21.82;3qxyQ-2fj0A:2.84"],["3RC0_A_SAMA484_0","N-LYSINE METHYLTRANSFERASE SETD6","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"ALA A 194;GLY A 195;TYR A 175;ALA A  61;TYR A  60","None","1.13A","3rc0A-2fj0A:undetectable","3rc0A-2fj0A:21.82"],["3RC0_B_SAMB480_0","N-LYSINE METHYLTRANSFERASE SETD6","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"ALA A 194;GLY A 195;TYR A 175;ALA A  61;TYR A  60","None","1.12A","3rc0B-2fj0A:undetectable","3rc0B-2fj0A:21.82"],["3U9F_S_CLMS221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"PHE A 173;THR A 232;LEU A 140;VAL A 170;PHE A 479","None","1.29A","3u9fP-2fj0A:undetectable;3u9fS-2fj0A:undetectable","3u9fP-2fj0A:15.08;3u9fS-2fj0A:15.08"],["3UT5_D_LOCD502_1","TUBULIN BETA CHAIN","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"LEU A 185;LEU A 292;MET A 295;ALA A 282;ILE A 278","None","0.96A","3ut5D-2fj0A:2.9","3ut5D-2fj0A:22.87"],["4DJF_B_C2FB300_0","5-METHYLTETRAHYDROFOLATE CORRINOID\/IRON SULFUR PROTEIN METHYLTRANSFERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"PHE A 458;ILE A 508;LEU A 140;GLY A 224;SER A 226","None;None;None;None;TFC A 600 (-1.4A)","1.31A","4djfB-2fj0A:undetectable","4djfB-2fj0A:19.16"],["4EY6_A_GNTA604_1","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"GLY A 145;GLY A 146;GLY A 147;SER A 226;PHE A 361;HIS A 471","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-4.4A);TFC A 600 (-4.2A)","0.64A","4ey6A-2fj0A:48.2","4ey6A-2fj0A:29.85"],["4EY6_A_GNTA604_1","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"GLY A 145;GLY A 146;GLY A 147;SER A 226;PHE A 361;HIS A 471","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-4.4A);TFC A 600 (-4.2A)","1.44A","4ey6A-2fj0A:48.2","4ey6A-2fj0A:29.85"],["4EY6_B_GNTB605_1","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"GLY A 145;GLY A 146;GLY A 147;SER A 226;PHE A 361;HIS A 471","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-4.4A);TFC A 600 (-4.2A)","0.64A","4ey6B-2fj0A:42.4","4ey6B-2fj0A:29.85"],["4EY6_B_GNTB605_1","ACETYLCHOLINESTERASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",6,"GLY A 145;GLY A 146;GLY A 147;SER A 226;PHE A 361;HIS A 471","TFC A 600 (-3.5A);TFC A 600 (-3.4A);TFC A 600 (-3.6A);TFC A 600 (-1.4A);TFC A 600 (-4.4A);TFC A 600 (-4.2A)","1.44A","4ey6B-2fj0A:42.4","4ey6B-2fj0A:29.85"],["4NJV_A_RITA500_2","PROTEASE;PROTEASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 224;GLY A 352;ILE A 351;PRO A 517;ILE A 508","None","0.91A","4njvB-2fj0A:undetectable","4njvB-2fj0A:10.66"],["4NJV_D_RITD500_1","PROTEASE;PROTEASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 224;GLY A 352;ILE A 351;PRO A 517;ILE A 508","None","0.96A","4njvC-2fj0A:undetectable","4njvC-2fj0A:10.66"],["4PFJ_B_ADNB502_1","ADENOSYLHOMOCYSTEINASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"HIS A 233;THR A 232;LEU A 432;LEU A 250;PHE A 245","None","1.34A","4pfjB-2fj0A:undetectable","4pfjB-2fj0A:22.86"],["4Q15_A_HFGA803_1","PROLINE--TRNA LIGASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",3,"GLU A 161;THR A 172;HIS A 118","None","0.83A","4q15A-2fj0A:undetectable","4q15A-2fj0A:20.57"],["4Q15_B_HFGB803_1","PROLINE--TRNA LIGASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",3,"GLU A 161;THR A 172;HIS A 118","None","0.84A","4q15B-2fj0A:undetectable","4q15B-2fj0A:20.57"],["4QCK_A_ASDA404_1","3-KETOSTEROID-9-ALPHA-MONOOXYGENASE OXYGENASE SUBUNIT","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"VAL A  91;GLN A  94;LEU A 308;MET A 103;LEU A  98","None","1.33A","4qckA-2fj0A:undetectable","4qckA-2fj0A:21.13"],["4X1I_D_LOCD502_1","TUBULIN BETA CHAIN","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"LEU A 185;LEU A 292;MET A 295;ALA A 282;ILE A 278","None","0.95A","4x1iD-2fj0A:2.6","4x1iD-2fj0A:22.07"],["4X1Y_D_LOCD502_2","TUBULIN BETA CHAIN","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"LEU A 185;LEU A 292;MET A 295;ALA A 282;ILE A 278","None","0.96A","4x1yD-2fj0A:2.6","4x1yD-2fj0A:22.07"],["4YDQ_B_HFGB802_1","PROLINE--TRNA LIGASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",3,"GLU A 161;THR A 172;HIS A 118","None","0.75A","4ydqB-2fj0A:undetectable","4ydqB-2fj0A:20.71"],["5DLV_A_5D5A930_1","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"SER A 423;TYR A 427;PHE A 559;TRP A 565","None","1.33A","5dlvA-2fj0A:1.4","5dlvA-2fj0A:22.73"],["5DZK_R_BEZR801_1","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"SER A 226;ALA A 227;HIS A 471;LEU A 313","TFC A 600 (-1.4A);TFC A 600 (-3.5A);TFC A 600 (-4.2A);TFC A 600 (-4.2A)","0.99A","5dzkd-2fj0A:2.4;5dzkr-2fj0A:undetectable","5dzkd-2fj0A:17.60;5dzkr-2fj0A:1.10"],["5DZK_T_BEZT801_1","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"SER A 226;ALA A 227;HIS A 471;LEU A 313","TFC A 600 (-1.4A);TFC A 600 (-3.5A);TFC A 600 (-4.2A);TFC A 600 (-4.2A)","1.09A","5dzkF-2fj0A:2.5;5dzkT-2fj0A:undetectable","5dzkF-2fj0A:17.60;5dzkT-2fj0A:1.10"],["5DZK_U_BEZU801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"PHE A 260;SER A 226;ALA A 227;HIS A 471","None;TFC A 600 (-1.4A);TFC A 600 (-3.5A);TFC A 600 (-4.2A)","1.28A","5dzkg-2fj0A:2.5;5dzku-2fj0A:undetectable","5dzkg-2fj0A:17.60;5dzku-2fj0A:1.10"],["5EML_A_SAMA701_1","PROTEIN ARGININE N-METHYLTRANSFERASE 5","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"TYR A 477;TYR A 447;GLY A 470;GLU A 473","None","1.34A","5emlA-2fj0A:undetectable","5emlA-2fj0A:23.20"],["5FHZ_A_REAA602_1","ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLY A 379;THR A 399;ASN A 263;PHE A 388;LEU A 387","None","1.22A","5fhzA-2fj0A:undetectable","5fhzA-2fj0A:22.78"],["5IQE_C_NMYC600_1","BIFUNCTIONAL AAC\/APH","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"ASP A 560;ASP A 557;TYR A 427;SER A 256;GLU A 336","None","1.49A","5iqeC-2fj0A:0.1","5iqeC-2fj0A:19.71"],["5KBW_B_RBFB201_1","RIBOFLAVIN TRANSPORTER RIBU","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"LEU A 183;ASP A 198;GLY A 195;ASN A 193;ASN A 271","None","1.39A","5kbwB-2fj0A:undetectable","5kbwB-2fj0A:16.19"],["5NM5_B_LOCB502_2","TUBULIN BETA-2B CHAIN","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"LEU A 185;LEU A 292;MET A 295;ALA A 282;ILE A 278","None","0.96A","5nm5B-2fj0A:3.0","5nm5B-2fj0A:22.24"],["5UUN_A_ACTA307_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"LEU A 331;LEU A 196;SER A 255;ALA A 231","None","1.13A","5uunA-2fj0A:undetectable","5uunA-2fj0A:18.78"],["6BXM_A_SAMA402_0","DIPHTHAMIDE BIOSYNTHESIS ENZYME DPH2","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"LEU A 137;GLY A 136;LEU A 203;ARG A 216;ASP A 218","None","1.06A","6bxmA-2fj0A:undetectable","6bxmA-2fj0A:21.40"],["6C71_B_NCTB501_1","AMINE OXIDASE","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",4,"LEU A 163;GLU A 161;THR A 505;ASN A 482","None","1.08A","6c71B-2fj0A:undetectable","6c71B-2fj0A:8.89"],["6DWN_C_AQ4C602_1","CYTOCHROME P450 1A1","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",3,"SER A 255;SER A 256;ALA A 340","None","0.63A","6dwnC-2fj0A:undetectable","6dwnC-2fj0A:10.34"],["6EFN_A_SAMA501_0","SPORULATION KILLING FACTOR MATURATION PROTEIN SKFB","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",5,"GLU A 357;PHE A 259;SER A 226;ALA A 227;LEU A 308","None;TFC A 600 (-4.0A);TFC A 600 (-1.4A);TFC A 600 (-3.5A);None","1.36A","6efnA-2fj0A:2.2","6efnA-2fj0A:22.51"],["6NKN_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2fj0","CARBOXYLIC ESTER HYDROLASE","Manduca sexta",3,"ARG A 362;PHE A 458;PHE A 365","None;None;TFC A 600 ( 4.9A)","1.06A","6nknC-2fj0A:undetectable;6nknJ-2fj0A:undetectable","6nknC-2fj0A:18.71;6nknJ-2fj0A:8.17"]]