SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fjc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)
2fjc ANTIGEN TPF1
(Treponema
pallidum)
4 / 8 VAL A 127
TYR A  56
TYR A  75
LEU A  72
None
0.98A 1z2bB-2fjcA:
undetectable
1z2bB-2fjcA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
2fjc ANTIGEN TPF1
(Treponema
pallidum)
5 / 12 LEU A  53
ILE A 168
ALA A 167
TYR A  75
LEU A 124
None
1.15A 2japA-2fjcA:
undetectable
2japA-2fjcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
2fjc ANTIGEN TPF1
(Treponema
pallidum)
5 / 12 LEU A  53
ILE A 168
ALA A 167
TYR A  75
LEU A 124
None
1.16A 2japB-2fjcA:
undetectable
2japB-2fjcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
2fjc ANTIGEN TPF1
(Treponema
pallidum)
5 / 12 LEU A  53
ILE A 168
ALA A 167
TYR A  75
LEU A 124
None
1.16A 2japC-2fjcA:
undetectable
2japC-2fjcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
2fjc ANTIGEN TPF1
(Treponema
pallidum)
5 / 12 LEU A  53
ILE A 168
ALA A 167
TYR A  75
LEU A 124
None
1.16A 2japD-2fjcA:
undetectable
2japD-2fjcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)
2fjc ANTIGEN TPF1
(Treponema
pallidum)
3 / 3 HIS A  42
ILE A 156
LEU A  93
None
0.66A 2kceA-2fjcA:
undetectable
2kceA-2fjcA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
2fjc ANTIGEN TPF1
(Treponema
pallidum)
4 / 8 ARG A 129
LEU A  53
TYR A  75
ILE A 120
None
0.88A 3ln1A-2fjcA:
undetectable
3ln1A-2fjcA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2fjc ANTIGEN TPF1
(Treponema
pallidum)
4 / 5 ALA A  44
ARG A  40
ALA A 106
GLU A 103
None
1.41A 5a06C-2fjcA:
undetectable
5a06D-2fjcA:
undetectable
5a06C-2fjcA:
19.41
5a06D-2fjcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)
2fjc ANTIGEN TPF1
(Treponema
pallidum)
4 / 6 HIS A  54
ASN A  55
TYR A  56
GLU A 112
None
1.36A 6gneA-2fjcA:
undetectable
6gneA-2fjcA:
15.71